Skip to main content

Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart

  • Conference paper
Amine Oxidases: Function and Dysfunction

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 41))

Summary

This study aimed to examine whether the increase in heart radioactivity levels after intravenous injection of 14C-tyramine to rats pretreated with the irreversible MAO inhibitor tranylcypromine could be antagonized by reboxetine, a potent and selective noradrenaline uptake blocker.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bieck PR, Antonin KH (1989) Tyramine potentiation during treatment with MAO inhibitors: brofaromine and moclobemide vs irreversible inhibitors. J Neural Transm [Suppl] 28: 21–31.

    CAS  Google Scholar 

  • Cocchiara G, Battaglia R, Pevarello P, Strolin Benedetti M (1991) Comparison of the disposition and of the metabolic pattern of reboxetine, a new antidepressant, in the rat, dog, monkey and man. Eur J Drug Metab Pharmacokinet 16: 231–239.

    Article  PubMed  CAS  Google Scholar 

  • Dollery CT, Brown MJ, Davies DS, Strolin Benedetti M (1984) Pressor amines and monoamine oxidase inhibitors. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors. Academic Press, London, pp 429–441.

    Google Scholar 

  • Dostert P (1984) Myth and reality of the classical MAO inhibitors. Reasons for seeking a new generation. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors. Academic Press, London, pp 9–24.

    Google Scholar 

  • Dostert P, Strolin Benedetti M, Sontag N (1981) Some biochemical aspects of the potential benefit of associating MD 780515 with tricyclic antidepressants. J Pharm Pharmacol 33: 639–643.

    Article  PubMed  CAS  Google Scholar 

  • Hendley ED, Snyder SH (1968) Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy. Nature 220: 1330–1331.

    Article  PubMed  CAS  Google Scholar 

  • Kan JP, Strolin Benedetti M (1981) Characteristics of the inhibition of rat brain monoamine oxidase in vitro by MD 780515. J Neurochem 36: 1561–1571.

    Article  PubMed  CAS  Google Scholar 

  • Korn A, Da Prada M, Raffesberg W, Allen S, Gasic S (1988) Tyramine pressor effect in man: studies with moclobemide, a novel, reversible monoamine oxidase inhibitor. J Neural Transm [Suppl] 26: 57–71.

    CAS  Google Scholar 

  • Melloni P, Carniel G, Della Torre A, Bonsignori A, Buonamici M, Pozzi O, Ricciardi S, Rossi AC (1984) Potential antidepressant agents. a-Aryloxy-benzyl derivatives of ethanolamine and morpholine. Eur J Med Chem 19: 235–242.

    CAS  Google Scholar 

  • Pare CMB, Hallstrom C, Kline N, Cooper TB (1982) Will amitriptyline prevent the “cheese” reaction of monoamine oxidase inhibitors? Lancet ii: 183–186.

    Article  Google Scholar 

  • Richelson E, Pfenning M (1984) Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. Eur J Pharmacol 104: 277–286.

    Article  PubMed  CAS  Google Scholar 

  • Riva M, Brunello N, Rovescalli AC, Galimberti R, Carfagna N, Carminati P, Pozzi O, Ricciardi S, Roncucci R, Rossi A, Racagni G (1989) Effect of reboxetine, a new antidepressant drug, on the central noradrenergic system: behavioural and biochemical studies. J Drug Dev 1: 243–253.

    Google Scholar 

  • Strolin Benedetti M, Dosiert P, Guffroy C, Tipton KF (1983) Partial or total protection from long-lasting monoamine oxidase inhibitors (MAOIs) by new short-acting MAOIs of type A MD 780515 and type B MD 780236. Mod Probi Pharmaco-psychiatry 19: 82–104.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag

About this paper

Cite this paper

Dostert, P., Castelli, M.G., Cicioni, P., Benedetti, M.S. (1994). Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart. In: Tipton, K.F., Youdim, M.B.H., Barwell, C.J., Callingham, B.A., Lyles, G.A. (eds) Amine Oxidases: Function and Dysfunction. Journal of Neural Transmission, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9324-2_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9324-2_21

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82521-1

  • Online ISBN: 978-3-7091-9324-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics