Summary
Using 15O (O2, CO2) and 18F-fluoro-deoxyglucose, a positron emission tomographic study was carried out to elucidate ongoing changes in a whole brain in cases with rigid- and tremor-type Parkinson’s disease (PA), respectively. For comparison, cases with essential tremor and normal control were also examined. MRI and XCT images and depth recording from basal ganglia during the course of stereotactic thalamotomy were considered together.
In rigid-type PA, cortical rCBF, rCMRO2 and rCMRGl were significantly reduced. However, 18FDG in basal ganglia (especially in the region of putamen and pallidum) was maintained in the normal or even in higher level. Microrecording also revealed reduced electrical activity in caudate nucleus, in contrast with higher activity in pallidum.
In tremor-type PA, the reduction of cortical metabolic rate was moderate, and activity in the caudate was maintained.
Metabolic rate in essential tremor and normal case seemed to be similar: it was high in cortical level and basasl ganglia (Cd was more active than putamen-pallidum).
Different metabolic features between rigid- and tremor- type PA were emphasized.
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Ohye, C. (1991). Positron emission tomographic study in Parkinson’s disease—rigid vs tremor type. In: Nagatsu, T., Narabayashi, H., Yoshida, M. (eds) Parkinson’s Disease. From Clinical Aspects to Molecular Basis. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9146-0_18
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DOI: https://doi.org/10.1007/978-3-7091-9146-0_18
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