Summary
The two possible dopamine donor sites for transplantation are autologous adrenal medulla and human foetal substantia nigra or adrenal medulla. There is increasing experience with the use of adrenal medulla transplantation for Parkinson’s disease and much less experience in foetal substantia nigra transplantation.
The particular problems of each technique are discussed with examples and postoperative progress of cases with the special emphasis on management problems.
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References
Backlund EO, Granberg P, Hamberger B etal (1985) Transplantation of adrenal medullary tissue to striatum in parkinsonism. J Neurosurg 162: 169–172
Bakay RAE, Fuandaca MS, Barrow DL etal (1985) Preliminary report on the use of fetal tissue transplantation to correct MPTP- induced Parkinson-like syndrome in primates. Appl Neurophysiol 48: 358–361
Hitchcock E (1988) Recent experience with dopamine transplantation for Parkinson’s disease. Proceeding of combined meeting Society of British Neurological Surgeons and Neurosurgical Society of Australia, Oxford, 14th April 1988. In press
Koller WC, Perlik S, Nausieda PA etal (1980) Drug holiday and management of Parkinson’s disease. Neurology 30: 1257–1261
Lindvall O, Backlund EO, Farde L etal (1987) Transplantation in Parkinson’s disease; two cases of adrenal medullary grafts to the putamen. Ann Neurol 22: 457–468
Madrazo I, Drucker-Colin R, Diaz V etal (1987) Open microsurgical autograft of adrenal medulla to the right caudate nucleus in 2 patients with intractable Parkinsons disease. New Engl J Med No 14, 316: 831–834
Madrazo I, Leon V, Torres C etal (1987) Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson’s disease. New Engl J Med No 1, 318: 51
Quinn NP (1987) Drug holiday. In: Koller WC (ed) Handbook of Parkinson’s disease. Dekker, New York, pp 328–329
Redmond ED, Roth RH, Elsworth JD etal (1986) Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet May 17, 1125–1127
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© 1989 Springer-Verlag
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Hitchcock, E.R., Clough, C.G., Hughes, R.C., Kenny, B.G. (1989). Transplantation in Parkinson’s Disease: Stereotactic Implantation of Adrenal Medulla and Foetal Mesencephalon. In: Broggi, G., Burzaco, J., Hitchcock, E.R., Meyerson, B.A., Tóth, S. (eds) Advances in Stereotactic and Functional Neurosurgery 8. Acta Neurochirurgica Supplementum, vol 46. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9029-6_11
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DOI: https://doi.org/10.1007/978-3-7091-9029-6_11
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