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Stereoselektive Totalsynthese von Indolalkaloiden

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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Zusammenfassung

Die synthetischen Arbeiten in der Reihe der polycyclischen Indol-alkaloide haben in den letzten 20 Jahren, beginnend mit der eindrucksvollen, eine neue Epoche synthetischer Strategie und Planung einleitenden Totalsynthese des Alkaloid-Veteranen Strychnin durch R. B. Wpoodward und Mitarbeiter (27), erhebliche Fortschritte gemacht. Da in den letzten Jahren aber außerdem auch die Biogenese dieser Alkaloide durch die Arbeiten von Arigoni, Battersby und Scott weitgehend geklärt werden konnte, wird in dem folgenden Überblick über stereoselektive totalsynthetische Vorhaben auf diesem inzwischen etwa 800 Alkaloide umfassenden Gebiet eine Einteilung gemäß der kürzlich von I. Kompis, M. Hesse und H. Schmid (32) vorgeschlagenen biogenetischen Klassifikation der Indolalkaloide vorgenommen. Als Kriterium für diese Einteilung der Indolalkaloide in Klassen ist die Anzahl der Bindungen zwischen den beiden wichtigen biogenetischen Bausteinen, nämlich dem Tryptophan (1) und dem Loganin (2) bzw. Secologanin (3), anzusehen.

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Authors and Affiliations

  1. Hannover, Deutschland

    E. Winterfeldt

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  1. E. Winterfeldt
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  1. Tallahassee, Fla., USA

    W. Herz

  2. Freiburg i. Br., Germany

    H. Grisebach

  3. Glasgow, UK

    G. W. Kirby

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Winterfeldt, E. (1974). Stereoselektive Totalsynthese von Indolalkaloiden. In: Herz, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 31. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7094-6_8

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  • DOI: https://doi.org/10.1007/978-3-7091-7094-6_8

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  • Print ISBN: 978-3-7091-7096-0

  • Online ISBN: 978-3-7091-7094-6

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