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Mechanism of 6-hydroxydopamine neurotoxicity

  • Conference paper
Advances in Research on Neurodegeneration

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURAL SUPPL,volume 50))

Summary

The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson’s disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity. 6-OHDA has two ways of action: it easly forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive towards radical scavengers and iron chelators with the exception of desferrioxamine. We conclude that free radicals ate not involved in the interaction between 6-OHDA and the respiratory chain and that the two mechanisms are biochemically independent, although they may act synergistically in vivo.

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Author notes

  1. Prof. Dr. M. B. H. Youdim

    Present address: Department of Pharmacology, Bruce Rappaport Faculty of Medicine, Technion, P.O.B. 9649, Haifa, 31096, Israel

Authors and Affiliations

  1. Department of Pharmacology, Bruce Rappaport Faculty of Medicine, Technion, P.O.B. 9649, Haifa, 31096, Israel

    Yelena Glinka & M. Gassen

Authors
  1. Yelena Glinka
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  2. M. Gassen
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  3. Prof. Dr. M. B. H. Youdim
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of WĂĽrzburg, Germany

    P. Riederer

  2. Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada

    D. B. Calne

  3. Clinical Research, Schering AG, Berlin, Germany

    R. Horowski

  4. Department of Neurology, Juntendo University, Tokyo, Japan

    Y. Mizuno

  5. Department of Neurology, University of Innsbruck, Austria

    W. Poewe

  6. Faculty of Medicine, Institute of Pharmacology, Technion — Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim

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© 1997 Springer-Verlag Wien

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Glinka, Y., Gassen, M., Youdim, M.B.H. (1997). Mechanism of 6-hydroxydopamine neurotoxicity. In: Riederer, P., Calne, D.B., Horowski, R., Mizuno, Y., Poewe, W., Youdim, M.B.H. (eds) Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementa, vol 50. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6842-4_7

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  • DOI: https://doi.org/10.1007/978-3-7091-6842-4_7

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82898-4

  • Online ISBN: 978-3-7091-6842-4

  • eBook Packages: Springer Book Archive

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