Skip to main content

Spectrum of cognitive, behavioural and emotional problems in children and young adults with Down syndrome

  • Chapter
Advances in Down Syndrome Research

Part of the book series: Journal of Neural Transmission Supplement 67 ((NEURAL SUPPL,volume 67))

Summary

In comparison to most other groups with intellectual disability individuals with Down syndrome are at lower risk for significant psychopathology, although relative to their typically developing peers they have higher rates of behavioural and emotional problems. A total of 43 Down syndrome patients (21 females and 22 males), who ranged in age from 5.33 to 30.58 years, were examined for the presence of age-related changes in the spectrum of externalizing and internalizing problems. Intelligence tests included Hamburg-Wechsler-Intelligenz Test für Kinder III (HAWIK-III), HamburgWechsler-Intelligenz Test für Erwachsene (HAWIE-R) and KaufmanAssessment-Battery for Children, German Version (K-ABC). Behavioural and emotional problems were assessed by the the Strengths and Difficulties Questionnaire for Parents, German Version (SDQ) and the Clinical Assessment Scale for Child and Adolescent Psychopathology (CASCAP). IQ was significantly inversly related to the age of patients. Externalizing behaviours (dominant, opposing/refusing, impulsiveness, inattention and increased motor activity) were significantly higher in the 5–10 years old group, whereas internalizing behaviours (shy/insecure, low selfconfidence, decreased motor activity) where more prevalent in adolescents and adults (10–30 years). Possible relationships between this age-related changes and increased risks of later-onset psychopathology (depression and dementia) are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aylward E, Burt D, Thorpe L, Lai F, Dalton A (1997) Diagnosis of dementia in individuals with intellectual disability: report of the task force for development of criteria for diagnosis of dementia in individuals with mental retardation. J Intellect Disabil Res 41: 152–164

    Article  PubMed  Google Scholar 

  • Bazelon M, Paine RS, Coeiw VA, Hunt P, Houck JC, Mahanand D (1967) Reversal of hypotonia in infants with Down’s syndrome by administration of 5hydroxytryptophan. Lancet i: 1130–1133

    Google Scholar 

  • Burt D, Loveland K, Primeaux-Hart S, Chen Y, Phillips N, Cleveland L, Lewis K, Lesser J, Cummings E (1998) Dementia in adults with Down Syndrome: diagnostic challenges. Am J Ment Retard 103: 130–145

    Article  PubMed  CAS  Google Scholar 

  • Coe DA, Matson JL, Russell DW, Slifer KJ, Capone GT, Baglio C, Stallings S (1999) Behavior problems of children with Down syndrome and life events. J Autism Dev Disord 29: 149–156

    Article  PubMed  CAS  Google Scholar 

  • Coleman M (1971) Infantile spasms associated with 5-hydroxytryptophan administered in patients with Down’s syndrome. Neurol 21: 911–919

    Article  CAS  Google Scholar 

  • Collacott RA (1999) People with Down syndrome and mental health needs. In: Bouras N (ed) Psychiatric and behavioural disorders in developmental disabilities and mental retardation. Cambridge University Press, Cambridge, pp 200–211

    Google Scholar 

  • Collacott RA, Cooper S, McGrother C (1992) Differential rates of psychiatric disorders in adults with Down’s syndrome compared to other mentally handicapped adults. Br J Psychiatry 161: 671–674

    Article  PubMed  CAS  Google Scholar 

  • Collacott RA, Cooper SA, Branford D, McGrother C (1998) Behaviour phenotype for Down’s syndrome. Br J Psychiatry 172: 85–89

    Article  PubMed  CAS  Google Scholar 

  • Cooper SA, Prasher VP (1998) Maladaptive behaviours and symptoms of dementia in adults with Down’s syndrome compared with adults with intellectual disability of other aetiologies. J Intellect Disabil Res 42: 293–300

    Article  PubMed  Google Scholar 

  • Cuskelly M, Dadds M (1992) Behavioural problems in children with Down’s syndrome and their siblings. J Child Psychol Psychiatry 33: 749–761

    Article  PubMed  CAS  Google Scholar 

  • Cuskelly M, Gunn P (1997) Behavior concerns. In: Pueschel SM, Sustrova M (eds) Adolescents with Down Syndrome. Paul H. Brookes, Baltimore London Toronto Sydney, pp 111–127

    Google Scholar 

  • Dalton A (1992) Dementia in Down syndrome: methods of evaluation. In: Nadel L, Epstein C (eds) Down Syndrome and Alzheimer disease. Wiley-Liss, New York, pp 51–76

    Google Scholar 

  • Döpfner M, Berner W, Flechtner H, Lehmkuhl G, Steinhausen H-C (1999) Clinical Assessment Scale for Child and Adolescent Psychopathology. Hogrefe, Göttingen Bern Toronto Seattle

    Google Scholar 

  • Dykens EM, Kasari C (1997) Maladaptive behaviour in children with Prader-Willi syndrome, Down syndrome, and non-specific mental retardation. Am J Ment Retard 102: 228–237

    Article  PubMed  CAS  Google Scholar 

  • Dykens EM, Hodapp RM, Evans DW (1994) Profiles and development of adaptive behavior in children with Down syndrome. Am J Ment Retard 98: 580–587

    PubMed  CAS  Google Scholar 

  • Dykens EM, Shah B, Sagun J, Beck T, King BH (2002) Maladaptive behaviour in children and adolescents with Down’s syndrome. J Intellect Disabil Res 46: 484–492

    Article  PubMed  CAS  Google Scholar 

  • Einfeld SL, Tonge BJ (1996) Population prevalence of psychopathology in children and adolescents with intellectual disability. II. Epidemiological findings. J Intellect Disabil Res 40: 99–109

    Article  PubMed  Google Scholar 

  • Epstein CJ (1995) Down Syndrome (Trisomy 21). In: Scriver SR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 749–794

    Google Scholar 

  • Frankenburg WK, Dodds JB (1990) Denver II developmental screening test. In: Stanhope M, Knollmueller RN (1992) Handbook of community and home health-nursing: tools for assessment intervention and education. Mosby, St. Louis, pp 317–319

    Google Scholar 

  • Gath A, Gumley D (1986) Behaviour problems in retarded children with special reference to Down’s syndrome. Br J Psychiatry 149: 156–161

    Article  PubMed  CAS  Google Scholar 

  • Gath A, Gumley D (1987) Retarded children and their siblings. J Child Psychol Psychiatry 5: 715–730

    Article  Google Scholar 

  • Gedye A (1990) Dietary increase in serotonin reduces self-injurious behaviour in a Down’s syndrome adult. J Ment Defic Res 34: 195–203

    PubMed  Google Scholar 

  • Gedye A (1991) Serotonergic treatment of aggression in a Down’s syndrome adult showing signs of Alzheimer’s disease. J Ment Defic Res 35: 247–258

    PubMed  Google Scholar 

  • Geldmacher DS, Lerner AJ, Voci JM, Noelker EA, Somple LC, Whitehouse PJ (1997) Treatment of functional decline in adults with Down syndrome using selective serotonin-reuptake inhibitor drugs. J Geriatr Psychiat Neurol 10: 99–104

    CAS  Google Scholar 

  • Gibson D, Groenewez G, Jerry P, Harris A (1988) Age and pattern of intellectual decline among Down Syndrome and other mentally retarded adults. Int J Rehabil Res 11: 47–55

    Article  PubMed  CAS  Google Scholar 

  • Godridge H, Reynolds GP, Czudek C, Calcutt NA, Benton M (1987) Alzheimer-like neurotransmitter deficits in adult Down’s syndrome brain tissue. J Neurol Neurosurg Psychiatry 50: 775–778

    Article  PubMed  CAS  Google Scholar 

  • Goodman R (1997) The strengths and difficulties questionnaire for parents, German version. J Child Psychol Psychiatry 38: 581–586

    Article  PubMed  CAS  Google Scholar 

  • Haxby JV (1989) Neuropsychological evaluation of adults with Down’s syndrome: patterns of selective impairment in nondemented old adults. J Ment Defic Res 33: 193–197

    PubMed  Google Scholar 

  • Haxby JV, Schapiro MB (1992) Longitudinal study of neuropsychological functions in older adults with Down syndrome. In: Epstein C, Nadel L (eds) Down syndrome and Alzheimer disease. Wiley Liss, New York, pp 35–50

    Google Scholar 

  • Helmstaedter C, Lendt M, Lux S (2001) Verbaler Lern-and Merkfähigkeitstest. Beltz, Göttingen

    Google Scholar 

  • Holland AJ, Hon J, Huppert FA, Stevens F, Watson P (1998) Population based study on the prevalence and presentation of dementia in adults with Down’s syndrome. Br J Psychiatry 172: 493–498

    Article  PubMed  CAS  Google Scholar 

  • Holland AJ, Hon J, Huppert FA, Stevens F (2000) Incidence and course of dementia in people with Down’s syndrome: findings from a population-based study. J Intellect Disabil Res 44: 138–146

    Article  PubMed  Google Scholar 

  • Johnson J, Head E, Kim R, Starr A, Cotman C (1999) Clinical and pathological evidence for a frontal variant of Alzheimer’s disease. Arch Neurol 56: 1233–1239

    Article  PubMed  CAS  Google Scholar 

  • Lai F, Williams R (1989) A prospective study of Alzheimer disease in Down syndrome. Arch Neurol 46: 849–853

    Article  PubMed  CAS  Google Scholar 

  • Lai F, Kammann E, Rebeck GW, Anderson A, Chen Y, Nixon RA (1999) APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurol 53: 331–336

    Article  CAS  Google Scholar 

  • Maluck A, Melchers P (1998) Kaufman Assessment Battery for Children. Differential evaluation of (partial) intellectual ability of mentally handicapped adults. Nervenarzt 69: 1007–1014

    Article  PubMed  CAS  Google Scholar 

  • Mann DM, Yates PO, Marcyniuk B, Rawndra CR (1985) Pathological evidence for neurotransmitter deficits in Down’s syndrome of middle age. J Ment Defic Res 29: 125–135

    PubMed  Google Scholar 

  • McCarthy J, Boyd J (2001) Psychopathology and young people with Down’s syndrome: childhood predictors and adult outcome of disorder. J Intellect Disabil Res 45: 99–105

    Article  PubMed  CAS  Google Scholar 

  • Melchers P, Preuß U (1991) Kaufman-Assessment-Battery for Children, German Version. Swets & Zeitlinger, Amsterdam

    Google Scholar 

  • Myers BA (1997) Psychiatric disorders. In: Pueschel SM, Sustrova M (eds) Adolescents with Down Syndrome. Paul H. Brookes, Baltimore London Toronto Sydney, pp 129–142

    Google Scholar 

  • Myers BA, Pueschel SM (1991) Psychiatric disorders in population with Down syndrome. J New Ment Dis 179: 609–613

    Article  CAS  Google Scholar 

  • Nelson LD, Orme D, Osann K, Lott IT (2001) Neurological changes and emotional functioning in adults with Down Syndrome. J Intellect Disabil Res 45: 450–456

    Article  PubMed  CAS  Google Scholar 

  • Pietrini P, Alexander GE, Furey ML, Hampel H, Guazelli M (2000) The neurometabolic landscape of cognitive decline: in vivo studies with positron emission tomography in Alzheimer’s disease. Int J Psychophysiol 37: 87–98

    Article  PubMed  CAS  Google Scholar 

  • Pueschel SM, Bernier JC, Pezzullo JC (1991) Behavioural observations in children with Down’s syndrome. J Ment Defic Res 35: 502–511

    PubMed  Google Scholar 

  • Risser D, Lubec G, Cairns N, Herrera-Marschitz M (1997) Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome. Life Sci 60: 1231–1237

    Article  PubMed  CAS  Google Scholar 

  • Rutter M, Tizard J, Yule W, Graham P, Whitmore K (1976) Research report: Isle of Wight Studies, 1964–1974. Psychol Med 6: 313–332

    Article  PubMed  CAS  Google Scholar 

  • Seidl R, Kaehler ST, Prast H, Singewald N, Cairns N, Gratzer M, Lubec G (1999) Serotonin (5-HT) in brains of adult patients with Down syndrome. J Neural Transm [Suppl] 57: 221–232

    CAS  Google Scholar 

  • St.Clair DF, Blackwood D (1985) Premature senility in Down’s syndrome. Lancet 6: 34

    Article  Google Scholar 

  • Stores R, Stores G, Fellows B, Buckley S (1998) Daytime behaviour problems and maternal stress in children with Down’s syndrome, their siblings, and non-intellectually disabled and other intellectually disabled peers. J Intellect Disabil Res 42: 228–237

    Article  PubMed  Google Scholar 

  • Tewes U (1994) Hamburg-Wechsler-Intelligenztest für Erwachsene. Huber, Bern Göttingen Toronto Seattle

    Google Scholar 

  • Tewes U, Rossmann P, Schallberger U (2000) Hamburg-Wechsler-Intelligenz Test für Kinder I II. Huber, Bern Göttingen Toronto Seattle

    Google Scholar 

  • Turner S, Sloper P (1996) Behaviour problems among children with Down’s Syndrome: prevalence, persistence and parental appraisal. J Appl Res Intellect Disabil 9: 129–144

    Article  Google Scholar 

  • Tyrrell J, Cosgrave M, McCarron M, McPherson J, Calvert J, Kelly A, McLaughlin M, Gill M, Lawlor BA (2001) Dementia in people with Down’s syndrome. Int J Geriatr Psychiatry 16: 1168–1174

    Article  PubMed  CAS  Google Scholar 

  • Visser FE, Aldenkamp AP, van Huffelen AC, et al. (1997) Prospective study of the prevalence of Alzheimer-type dementia in institutionalised individuals with Down syndrome. Am J Ment Retard 101: 400–412

    PubMed  CAS  Google Scholar 

  • Warren AC, Holroyd S, Folstein P (1989) Major depression in Down’s syndrome. Br J Psychiatry 155: 202–207

    Article  PubMed  CAS  Google Scholar 

  • Warren AC, Holroyd S, Folstein MP (1990) Mayor depression in Down’s syndrome. Br J Psychiatry 155: 202–205

    Article  Google Scholar 

  • Weise P, Koch R, Shaw KNF, Rosenfeld MJ (1974) The use of 5-HTP in the treatment of Down’s syndrome. Pediatr 54: 165–167

    CAS  Google Scholar 

  • Wisniewski KE, Wisniewski HM, Wen GY (1985) Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down syndrome. Ann Neurol 17: 278–282

    Article  PubMed  CAS  Google Scholar 

  • Yates CM, Simpson J, Gordon A (1986). Regional brain 5-hydroxytryptamine levels are reduced in senile Down’s syndrome as in Alzheimer’s disease. Neurosci Lett 65: 189–192

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag

About this chapter

Cite this chapter

Nicham, R. et al. (2003). Spectrum of cognitive, behavioural and emotional problems in children and young adults with Down syndrome. In: Lubec, G. (eds) Advances in Down Syndrome Research. Journal of Neural Transmission Supplement 67, vol 67. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6721-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6721-2_16

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-40776-9

  • Online ISBN: 978-3-7091-6721-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics