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Cholinergic and monoaminergic neuromediator systems in DAT. Neuropathological and neurochemical findings

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Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics

Part of the book series: Key Topics in Brain Research ((KEYTOPICS))

Summary

The patterns of cholinergic (activity of choline acetyltransferase) and monoaminergic (concentrations of noradrenaline, dopamine, homovanillic acid, serotonin and 5-hydroxyindoleacetic acid) neuromediator systems were studied in postmortem tissue of the cortical lobes in each seven cases of patients with dementia of Alzheimer type (DAT) and controls. The findings show severe degenerations of neurons and deficits of neurotransmitters in all neuromediator systems. These results suggest that a substitutional therapy of only one neuromediator deficiency will not be clinically effective.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Division of Clinical Neurochemistry, University of Würzburg, Federal Republic of Germany

    W. Gsell & P. Riederer

  2. Ludwig Boltzmann Institute for Clinical Neurobiology, Department of Neurology, Lainz Hospital, Vienna, Austria

    I. Wichart & K. Jellinger

  3. Department of Psychiatry, Division of Clinical Neurochemistry, University of Würzburg, Füchsleinstrasse 15, D-8700, Würzburg, Federal Republic of Germany

    Dr. G. Moll

Authors
  1. Dr. G. Moll
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  2. W. Gsell
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  3. I. Wichart
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  4. K. Jellinger
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  5. P. Riederer
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

    Konrad Maurer , Peter Riederer  & Helmut Beckmann ,  & 

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© 1990 Springer-Verlag Wien

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Moll, G., Gsell, W., Wichart, I., Jellinger, K., Riederer, P. (1990). Cholinergic and monoaminergic neuromediator systems in DAT. Neuropathological and neurochemical findings. In: Maurer, K., Riederer, P., Beckmann, H. (eds) Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-3396-5_24

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  • DOI: https://doi.org/10.1007/978-3-7091-3396-5_24

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82197-8

  • Online ISBN: 978-3-7091-3396-5

  • eBook Packages: Springer Book Archive

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