Abstract
Proteolysis is arguably the most important of all post-translational modifications in that it is effectively irreversible, and leads to the partial or complete breakdown of proteins. Cells have adapted various mechanisms to control proteolysis as despite its importance, its destructive nature requires tight regulation. Evidence now clearly shows that the loss of proteolytic regulation is a key component in the progression of various pathophysiologies from metabolic disorders to cancer. This chapter discusses the central role for cellular compartmentalization of proteolysis to ensure homeostasis and highlights examples of how the loss of this regulation can promote disease.
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Brix, K., Scott, C.J., Heck, M.M.S. (2013). Compartmentalization of Proteolysis. In: Brix, K., Stöcker, W. (eds) Proteases: Structure and Function. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0885-7_3
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