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Neutrophil Depletion Diminishes Monocyte Infiltration and Improves Functional Outcome After Experimental Intracerebral Hemorrhage

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Intracerebral Hemorrhage Research

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 111))

Abstract

Inflammation contributes to secondary injury and neuronal loss after intracerebral hemorrhage, but the role of individual immune populations in these processes is unclear. In a mouse model, the injection of autologous blood into the striatum was associated with an intense inflammatory cell infiltrate composed of neutrophils, monocytes, and dendritic cells. Selective depletion of neutrophils resulted in decreased infiltration of monocytes and improved functional outcomes at day 3 post-hemorrhage. These findings indicate that neutrophil infiltration into the site of hemorrhage contributes to brain injury either by direct cellular damage or the recruitment of monocytes.

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Disclosure/conflict of interest statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Neurology, University of Pennsylvania Medical Center, 3 W Gates, 3400 Spruce Street, Philadelphia, PA, USA

    Lauren H. Sansing

  2. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Tajie H. Harris & Christopher A. Hunter

  3. Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA, USA

    Scott E. Kasner

  4. Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, PA, USA

    Katalin Kariko

Authors
  1. Lauren H. Sansing
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  2. Tajie H. Harris
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  3. Scott E. Kasner
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  4. Christopher A. Hunter
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  5. Katalin Kariko
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Corresponding author

Correspondence to Lauren H. Sansing .

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Editors and Affiliations

  1. , Neurosurgery, Physiology, Loma Linda University, Campus Street 11041, Loma Linda, 92530, USA

    John Zhang

  2. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    Austin Colohan

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© 2011 Springer-Verlag/Wien

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Sansing, L.H., Harris, T.H., Kasner, S.E., Hunter, C.A., Kariko, K. (2011). Neutrophil Depletion Diminishes Monocyte Infiltration and Improves Functional Outcome After Experimental Intracerebral Hemorrhage. In: Zhang, J., Colohan, A. (eds) Intracerebral Hemorrhage Research. Acta Neurochirurgica Supplementum, vol 111. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0693-8_29

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  • DOI: https://doi.org/10.1007/978-3-7091-0693-8_29

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0692-1

  • Online ISBN: 978-3-7091-0693-8

  • eBook Packages: MedicineMedicine (R0)

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