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Brain edema from intracerebral hemorrhage

  • Conference paper
Brain Edema XII

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 86))

Abstract

Sequential changes in brain parenchyma surrounding an intracerebral hemorrhage are described here. Re-bleeding occurs within the first several hours after the initial hemorrhage in about 30% of cases. The coagulation cascade is activated as soon as blood encounters tissue. Perihematomal brain edema develops in response to clot retraction, thrombin formation, erythrocyte lysis, hemoglobin toxicity, complement activation, mass effect, and blood-brain barrier disruption. Early hematoma evacuation interrupts edema formation. The toxicity of extravasated blood in brain parenchyma has not been studied well in traumatic injury or in hemorrhagic tumor models yet, but similar mechanisms of edema formation are likely to occur in these conditions.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan Health System, 1500 E. Medical Center Drive, Room 2128TC, Ann Arbor, Michigan, 48109-0338, USA

    Julian T. Hoff M.D. & G. Xi

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  1. Julian T. Hoff M.D.
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  2. G. Xi
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Editor information

Editors and Affiliations

  1. Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    T. Kuroiwa

  2. Institute für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Germany

    A. Baethmann

  3. Department of Neurosurgery, Polish Academy of Scienes, Warsaw, Poland

    Z. Czernicki

  4. Section of Neurosurgery, University of Michigan, Ann Arbor, USA

    J. T. Hoff

  5. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    U. Ito

  6. Department of Neurological Surgery, Nihon University, Tokyo, Japan

    Y. Katayama

  7. Medical College of Virgina, Richmond, USA

    A. Marmarou

  8. Department of Neurosurgery, Newcastle Gerneral Hospital, Newcastle-upon-Tyne, UK

    B. A. D. Mendelow

  9. Neurochirurgische Universitätklinik, Ludwig-Maximilians-Universität, München, Germany

    H.-J. Reulen

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© 2003 Springer-Verlag Wien

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Hoff, J.T., Xi, G. (2003). Brain edema from intracerebral hemorrhage. In: Kuroiwa, T., et al. Brain Edema XII. Acta Neurochirurgica Supplements, vol 86. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0651-8_3

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  • DOI: https://doi.org/10.1007/978-3-7091-0651-8_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7220-9

  • Online ISBN: 978-3-7091-0651-8

  • eBook Packages: Springer Book Archive

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