Skip to main content

Vorhersagewerte von Beta-trace Protein (Prostaglandin D Synthase) mittels Laser-Nephelometer zur Identifikation von Liquor

  • Conference paper
Schädelbasischirurgie

Zusammenfassung

Liquorfisteln können als Folge von Traumen, chirurgischen Eingriffen, Fehlbildungen oder Tumorwachstum auftreten. In seltenen Fällen bleibt die Ätiologie unbekannt [1–3]. Da Liquorfisteln lebensbedrohlichen Komplikationen vorausgehen, sind diagnostische Werkzeuge zum Nachweis von Liquorspuren erwünscht [4, 5]. Idealerweise sollte die Methode nicht-in-vasiv, nicht-strahlenbelastend und labortechnisch mit kleinen Probenmengen und einem standardisiertem Verfahren durchführbar sein. Nur Labortests unter der Verwendung von Liquormarkern werden diesen Anforderungen gerecht.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Gormley WB, Sekhar LN, Wright DC, Kamerer D, Schessel D (1997) Acoustic neuromas: results of current surgical management. Neurosurgery 41(1): 50–58

    Article  PubMed  CAS  Google Scholar 

  2. Park TS, Hoffman HJ, Humphreys RP, Chuang H (1982) Spontaneous cerebrospinal fluid otorrhea in association with a congenital defect of the cochlear aqueduct and Mondini dysplasia. Neurosurgery 11(3): 356–362

    Article  PubMed  CAS  Google Scholar 

  3. Simmen D, Bischoff T, Schuknecht B (1997) Erfahrungen mit der Abklärung von Frontobasisdefekten, ein diagnostisches Konzept. Laryngo-Rhino-Otol 76: 583–587

    Article  CAS  Google Scholar 

  4. Crawford C, Kennedy N, Weir WR (1994) Cerebrospinal fluid rhinorrhoea and haemophilus influenzae meningitis 37 years after a head injury. J Infect 28(1): 93–97

    Article  PubMed  CAS  Google Scholar 

  5. Salca HC, Danaila L (1997) Onset of uncomplicated cerebrospinal fluid fistula 27 years after head injury: case report. Surg Neurol 47(2): 132–133

    Article  PubMed  CAS  Google Scholar 

  6. Stammberger H, Greistorfer K, Wolf G, Luxenberger W (1997) Operativer Verschluss von Liquorfisteln der vorderen Schädelbasis unter intrathekaler Natriumfluoreszeinanwendung. Laryngo Rhino Otol 76: 595–607

    Article  CAS  Google Scholar 

  7. Lanza DC, O’Brian DA, Kennedy DW (1997) Endoscopic repair of cerebrospinal fluid fistulae and encephaloceles. Laryngoscope 106: 1119–1125

    Article  Google Scholar 

  8. Hughes RG, Jones NS, Robertson IJ (1997) The endoscopic treatment of cerebrospinal fluid rhinorrhoea: the Nottingham experience. J Laryngol Otol 111(2): 125–128

    Article  PubMed  CAS  Google Scholar 

  9. Kelley TF, Stankiewicz JA, Chow JM, Origitano TC, Shea J (1996) Endoscopic closure of postsurgical anterior cranial fossa cerebrospinal fluid leaks. Neurosurgery 39(4): 743–746

    Article  PubMed  CAS  Google Scholar 

  10. McCormack B, Cooper PR, Persky M, Rothstein S (1990) Extracranial repair of cerebrospinal fluid fistulas: technique and results in 37 patients. Neurosurgery 27(3): 412–417

    Article  PubMed  CAS  Google Scholar 

  11. Hoffmann A, Conradt HS, Gross G, Nimtz M, Lottspeich F, Wurster U (1993) Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. J Neurochem 61(2): 451–456

    Article  PubMed  CAS  Google Scholar 

  12. Bachmann G, Baldus SE, Nekic M, Michel O (1998) Beta-trace protein in human perilymph. In: Reid A, Marchbanks RJ, Ernst A (eds) Intracranial and inner-ear physiology and pathophysiology. Whurr Publ Ltd, London, pp 193–196

    Google Scholar 

  13. Huber AR (2000) Zur neuen Diagnostik von Liquorfisteln. HNO 48: 478–488

    Article  Google Scholar 

  14. Bachmann G, Nekic M, Michel O (2000) Clinical experience with beta-trace protein as a marker for cerebrospinal fluid. Ann Otol Rhinol Laryngol 109(12): 1099–1102

    PubMed  CAS  Google Scholar 

  15. Petereit HF, Bachmann G, Nekic M, Althaus H, Pukrop R (2001) A new nephelometric assay for beta-trace protein (prostaglandin D synthase) as an indicator of liquorrhoea. J Neurol Neurosurg Psychiatry 71: 347–351

    Article  PubMed  CAS  Google Scholar 

  16. Kleine TO, Damm T, Althaus H (2000) Quantification of 3-trace protein and detection of transferrin isoforms in mixtures of cerebrospinal fluid and blood serum as models of rhinorrhea and otorrhea diagnosis. Fresenius J Anal Chem 366: 382–386

    Article  PubMed  CAS  Google Scholar 

  17. Har-El G (1999) What is „spontaneous“ cerebrospinal fluid rhinorrhea? Classification of cerebrospinal fluid leaks. Ann Otol Rhinol Laryngol 108: 323–326

    PubMed  CAS  Google Scholar 

  18. Hull HF, Morrow G (1975) Glucorrhea revisited. Prolonged promulgation of another plastic pearl. JAMA 234(10): 1052–1053

    Article  PubMed  CAS  Google Scholar 

  19. Jones NS, Becker DG (2001) Advances in the management of CSF leaks. BMJ 322(7279): 122–123

    Article  PubMed  CAS  Google Scholar 

  20. Meurman OH, Irjala K, Suonpaa J, Laurent B (1979) A new method for the identification of cerebrospinal fluid leakage. Acta Otolaryngol 87(3–4): 366–369

    Article  PubMed  CAS  Google Scholar 

  21. Oberascher G, Arrer E (1986) Immunologische Liquordiagnostik mittels β2-transferrin — Grundlagen und Methodik. Laryng Rhinol Otol 65: 158–161

    Article  CAS  Google Scholar 

  22. Nandapalan V, Watson ID, Swift AC (1996) Beta-2-transferrin and cerebrospinal fluid rhinorrhoea. Clin Otolaryngol 21: 259–264

    Article  PubMed  CAS  Google Scholar 

  23. Skedros DG, Cass SP, Hirsch BE, Kelly RH (1993) Sources of error in use of beta-2 transferrin analysis for diagnosing perilymphatic and cerebral spinal fluid leaks. Otolaryngol Head Neck Surg 109(5): 861–864

    PubMed  CAS  Google Scholar 

  24. Clausen J (1961) Proteins in normal cerebrospinal fluid not found in serum. Proc Soc Exp Biol Med 107: 170–172

    PubMed  CAS  Google Scholar 

  25. Felgenhauer K, Schädlich HJ, Nekic M (1987) Beta-trace protein as marker for cerebrospinal fluid fistula. Klin Wochenschr 65: 764–768

    Article  PubMed  CAS  Google Scholar 

  26. Tumani H, Reiber G, Nau R, Prange HW, Kauffmann K, Mäder M, Felgenhauer K (1998) Beta-trace protein concentration in cerebrospinal fluid is decreased in patients with bacterial meningitis. Neurosci Lett 242(l):5–8

    Article  PubMed  CAS  Google Scholar 

  27. Arrer E, Meco C, Oberascher G, Piotrowski W, Albegger K, Patsch W (2002) Beta-trace protein as a marker for cerebrospinal fluid rhinorrhea. Clin Chem 48(6): 939–941

    PubMed  CAS  Google Scholar 

  28. Reiber H, Walther K, Althaus H (2003) Beta-trace protein as sensitive marker for CSF rhinorhea and CSF otorhea. Acta Neurol Scand 108(5): 359–362

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to G. Bachmann .

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Wien

About this paper

Cite this paper

Bachmann, G., Petereit, H., Djenabi, U., Michel, O. (2004). Vorhersagewerte von Beta-trace Protein (Prostaglandin D Synthase) mittels Laser-Nephelometer zur Identifikation von Liquor. In: Schädelbasischirurgie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0622-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-0622-8_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-22324-6

  • Online ISBN: 978-3-7091-0622-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics