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The Role of Orthobiologics in Return to Play

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Return to Play in Football

Abstract

Bioactive proteins and growth factors are an integral component of healing processes and have the potential to affect metabolic cascades that impact tissue regeneration at all stages. These factors can be used in athletes for a wide variety of musculoskeletal injuries in the form of such biologics as platelet-rich plasma, or in conjunction with cellular therapies, to facilitate return to play. Cellular therapies, most often used in the form of mesenchymal stem cell isolates, are increasingly being used to treat athletic injury. In addition to tendinous or ligamentous injury, mesenchymal stem cell therapies are used to treat articular cartilage lesions. In combination with biologic scaffolding, mesenchymal stem cell isolates can be used to treat cartilage lesions of wide ranging sizes and severity. Orthobiologic therapies are advancing rapidly and are used to treat a large spectrum of injuries, helping to facilitate return to play at all levels of football competition.

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Author information

Authors and Affiliations

  1. Orthopaedic Arthroscopic Surgery International (OASI) Bioresearch Foundation, NPO, Via G.A. Amadeo, 24, 20133, Milan, Italy

    Graeme P. Whyte M.D., M.Sc., F.R.C.S.C., Alberto Gobbi M.D. & John G. Lane

  2. Cornell University, Weill Medical College, New York Presbyterian Hospital/Queens, New York, NY, USA

    Graeme P. Whyte M.D., M.Sc., F.R.C.S.C.

  3. Musculoskeletal and Joint Research Foundation, San Diego, CA, USA

    John G. Lane

Authors
  1. Graeme P. Whyte M.D., M.Sc., F.R.C.S.C.
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  2. Alberto Gobbi M.D.
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  3. John G. Lane
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Corresponding author

Correspondence to Alberto Gobbi M.D. .

Editor information

Editors and Affiliations

  1. UPMC Rooney Sports Complex, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Volker Musahl

  2. Department of Orthopaedics, University of Gothenburg, Gothenburg, Sweden

    Jón Karlsson

  3. Department of Trauma Surgery, University Medical Centre Regensburg, Regensburg, Germany

    Werner Krutsch

  4. Santa Monica, California, USA

    Bert R. Mandelbaum

  5. Clínica do Dragão, Espregueira-Mendes Sports Centre, Porto, Portugal

    João Espregueira-Mendes

  6. Orthopaedic Surgery, Aspetar Hospital, Doha, Qatar

    Pieter d'Hooghe

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Whyte, G.P., Gobbi, A., Lane, J.G. (2018). The Role of Orthobiologics in Return to Play. In: Musahl, V., Karlsson, J., Krutsch, W., Mandelbaum, B., Espregueira-Mendes, J., d'Hooghe, P. (eds) Return to Play in Football. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55713-6_23

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  • DOI: https://doi.org/10.1007/978-3-662-55713-6_23

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