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Clinical Applications of Adipose Tissue-Derived Stem Cells

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Bio-orthopaedics

Abstract

In the field of regenerative cellular therapy, mesenchymal stem cells (MSCs) have been extensively investigated, and various therapeutic protocols involving their use have been developed for clinical applications. There has been growing interest in the use of adipose tissue as a source of MSCs, due to the abundance of available tissue, and ease of access. Adipose tissue contains cells that are capable of differentiating into bone, muscle, and cartilage. Initial experimental research has demonstrated the capability of these cells to promote cartilage regeneration and improve symptoms related to degenerative cartilage injury. Recent technological developments allow for the microfragmentation of autologous adipose tissue to create isolates that have demonstrated potential for use in a number of chondropathic conditions, from localized traumatic cartilage injury, to more advanced conditions such as osteoarthritis.

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Author information

Authors and Affiliations

  1. Orthopaedic Arthroscopic Surgery International Bioresearch Foundation Gobbi N.P.O., Milan, Italy

    Alberto Gobbi & Graeme P. Whyte

  2. Biotechnology Orthopaedic Laboratory, Galeazzi Orthopaedic Institute, Milan, Italy

    Laura de Girolamo

  3. New York Presbyterian Hospital/Queens, New York, NY, USA

    Graeme P. Whyte

  4. Nostra Signora della Mercede Clinic, Rome, Italy

    Fabio Valerio Sciarretta

Authors
  1. Alberto Gobbi
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  2. Laura de Girolamo
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  3. Graeme P. Whyte
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  4. Fabio Valerio Sciarretta
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Corresponding author

Correspondence to Laura de Girolamo .

Editor information

Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

    Alberto Gobbi

  2. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  3. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John G. Lane

  4. Department of Orthopedics, Acibadem University, Istanbul, Turkey

    Mustafa Karahan

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© 2017 ISAKOS

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Gobbi, A., de Girolamo, L., Whyte, G.P., Sciarretta, F.V. (2017). Clinical Applications of Adipose Tissue-Derived Stem Cells. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_44

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  • DOI: https://doi.org/10.1007/978-3-662-54181-4_44

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54180-7

  • Online ISBN: 978-3-662-54181-4

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