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Pulmonary Hypertension: Pathology

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Pharmacotherapy of Pulmonary Hypertension

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 218))

Abstract

Pulmonary hypertension (PH) is a life-threatening and often fatal disease, characterized by elevated pulmonary vascular resistance and secondary right ventricular failure. Since etiologies of PH are multiple and its pathogenesis is complex, histology from lungs of patients with PH may help us to determine different etiological factors of the disease. The degree of involvement of various cell types and structures within the lung tissue represents an important indicator of the pathophysiologal process. So even if the role for pathologists in routine management of PH is limited, lessons can be learned from morphology. The present chapter outlines the current understanding of this disease from the pathologist’s point of view.

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Authors and Affiliations

  1. Service d’Anatomie et de Cytologie Pathologiques, Hôpital Marie Lannelongue, 133, Avenue de la Résistance, Le Plessis Robinson, France

    Peter Dorfmüller

  2. INSERM U999 “Hypertension Artérielle Pulmonaire: Physiopathologie et Innovation Thérapeutique”, 133, Avenue de la Résistance, Le Plessis Robinson, France

    Peter Dorfmüller

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  1. Peter Dorfmüller
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Correspondence to Peter Dorfmüller .

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Editors and Affiliations

  1. Faculte´ de Me´decine, Univ Paris-Sud, Le Kremlin Bicêtre, France

    Marc Humbert

  2. Dep of Anasthesia and Critical Care, Harvard Medical School Massachusetts General Hospital, Boston, Massachusetts, USA

    Oleg V. Evgenov

  3. Cardiovascular Research, Bayer Pharma AG, Wuppertal, Germany

    Johannes-Peter Stasch

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Dorfmüller, P. (2013). Pulmonary Hypertension: Pathology. In: Humbert, M., Evgenov, O., Stasch, JP. (eds) Pharmacotherapy of Pulmonary Hypertension. Handbook of Experimental Pharmacology, vol 218. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38664-0_3

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