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Commercial Plant-Produced Recombinant Avidin

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Commercial Plant-Produced Recombinant Protein Products

Part of the book series: Biotechnology in Agriculture and Forestry ((AGRICULTURE,volume 68))

Abstract

Recombinant egg white avidin was the first recombinant protein product manufactured and sold from a plant system. Recombinant avidin is functionally equivalent to chicken avidin, including its binding activity to biotin. This recombinant protein was used to demonstrate that plants cannot only be used to express animal proteins but these could be purified economically to produce a competitive product. Recombinant avidin was also in ground corn meal that was fed to mice to demonstrate that the protein can survive the digestive system and elicit antibodies when orally delivered in the corn matrix. Thus, avidin demonstrated the utility of the plant production system in general as well as its utility as a delivery system for oral vaccines.

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Authors and Affiliations

  1. Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR, 72467, USA

    Elizabeth E. Hood

  2. Applied Biotechnology Institute, CalPoly Technology Park, San Luis Obispo, CA, 93407, USA

    John A. Howard

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  1. Elizabeth E. Hood
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  2. John A. Howard
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Correspondence to Elizabeth E. Hood .

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Editors and Affiliations

  1. Cal Poly Technology Park, Applied Biotechnology Institute, San Luis Obispo, California, USA

    John A. Howard

  2. Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas, USA

    Elizabeth E. Hood

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Hood, E.E., Howard, J.A. (2014). Commercial Plant-Produced Recombinant Avidin. In: Howard, J., Hood, E. (eds) Commercial Plant-Produced Recombinant Protein Products. Biotechnology in Agriculture and Forestry, vol 68. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43836-7_2

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