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The Morphology of Hormone Induced Structural Changes in the Female Breast

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Current Topics in Pathology

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 53))

Abstract

Many morphological, physiological, and biochemical investigations have contributed to the classification of the endocrine regulatory mechanisms responsible for development and function of the mammary gland. These studies received their crucial impetus when the synthesis of the sex hormones had been achieved and from their experimental use. The history of the use of these drugs is thus also the history of the concept of control of the mammary gland by hormones. The individual factors and combinations of factors responsible for the normal growth of the glandular structure of the mammary gland, for its secretory function, and for its pathomorphology have been elucidated by systematic studies. The laws that have been discovered have led to a classification of reaction types and have made it possible for experimental observations to be compared with the responses of the human mammary gland. Current concepts of quantitative morphology and endocrinology have broadened our understanding of the mechanisms of the action of sex hormones on the mammary gland. Generally valid concepts of hormonal regulation of growth and metabolism have been derived from this.

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References

  • Adair, F. E.: Plasma cell mastitis. Arch. Surg. 26, 735–749 (1933).

    Article  Google Scholar 

  • AhrĂ©n, K.: (a) The effect of various doses of oestrone and progesterone on mammary glands of castrated hypophysectomized rats injected with insulin. Acta endocr. (Kbh.) 30, 435–458 (1959).

    Google Scholar 

  • AhrĂ©n, K.: (b) Mammary gland development in hypophysectomized rats injected with anterior pituitary hormones and testosterone. Acta endocr. (Kbh.) 31, 228–240 (1959).

    Google Scholar 

  • AhrĂ©n, K., Etienne, M.: Stimulation of mammary glands in hypophysectomized male rats treated with ovarian hormones and insulin. Acta endocr. (Kbh.) 28, 89–102 (1958).

    Google Scholar 

  • AhrĂ©n, K., Etienne, M.: The effect of testosterone alone and combined with insulin on the mammary glands of castrated and hypophysectomized rats. Acta endocr. (Kbh.) 30, 109–136 (1959).

    Google Scholar 

  • AhrĂ©n, K., Hamberger, L.: Direct action of testosterone propionate on the rat mammary gland. Acta endocr. (Kbh.) 40, 265–276 (1962).

    Google Scholar 

  • AhrĂ©n, K., Jacobsohn, D.: Mammary gland growth in hypophysectomized rats injected with ovarian hormones and insulin. Acta physiol. scand. 37, 190–203 (1956).

    Article  PubMed  Google Scholar 

  • AhrĂ©n, K., Jacobsohn, D.: The action of Cortison on the mammary glands of rats under various states of hormonal imbalance. Acta physiol. scand. 40, 254–274 (1957).

    Article  PubMed  Google Scholar 

  • Ahumada, I. C., Del Castillo, E. B.: Amenorrea galactorrea. Biol. Soc. obstet, y Ginec. 11, 64–72 (1932).

    Google Scholar 

  • Albores Culebro, C.: Un caso de ginecomastia o andro galactozemia. TorĂ©on mĂ©d. 1, 80 (1946).

    Google Scholar 

  • Altmann, H. W.: Der Zellersatz, insbesondere an den parenchymatösen Organen. Verh. dtsch. Ges. Path. 50, 15–51 (1966).

    Google Scholar 

  • Anderson, R. R., Brookreson, A. D., Turner, C.W.: Experimental growth of mammary gland in male and female mice. Proc. Soc. exp. Biol. (N. Y.) 106, 567–570 (1961).

    Article  CAS  Google Scholar 

  • Argonz, J., Del Castillo, E. B.: A syndrome characterized by estrogenic insufficiency, galactorrhea and decreased urinary gonadotropin. J. clin. Endocr. 13, 79–87 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Arhelger, St. W., Husely, R. A.: Estrogen-Androgen antagonism: Histology of mammary glands and vaginal grafts of male mice receiving estrogens. Proc. Soc. exp. Biol. (N. Y.) 76, 811–817 (1951).

    Article  CAS  Google Scholar 

  • Aristoteles: Historia animalium. Lit. III. c. 20. Zit. nach Wenner.

    Google Scholar 

  • Asboe-Hansen, G.: Hormonal effects on connective tissue. Physiol. Rev. (Baltimore) 38, 446–462 (1958).

    CAS  Google Scholar 

  • Asboe-Hansen, G.: Endocrine control of connective tissue. Amer. J. Med. 26, 470–484 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Astwood, E. B., Geschickter, C. F.: Changes in mammary gland of rat produced by various glandular preparations. Arch. Surg. 36, 672–697 (1938).

    Article  CAS  Google Scholar 

  • Astwood, E. B., Geschickter, C. F., Rausch, E. O.: Development of the mammary gland of the rat. A study of normal, experimental and pathologic changes and their endocrine relationships. Amer. J. Anat. 61, 373–405 (1937).

    Article  CAS  Google Scholar 

  • Averbach, M. M.: Ăśber die Histogenese der Mastopathien und Fibroadenome der Mammae. Arch. Path. (Moskau) 18, H. 3, 65–71 (1956) [Russisch]. Ref. Ber. allg. spez. Path. 34, 186 (1957).

    Google Scholar 

  • Averill, R. L. W.: The hypothalamus and lactation. Brit. med. Bull. 22, 261–265 (1966).

    PubMed  CAS  Google Scholar 

  • Averill, R. L. W., Ray, E. W., Lyons, W. R.: Maintenance of pregnancy in hypophysectomized rats with placental implants. Proc. Soc. exp. Biol. (N. Y.) 75, 3–6 (1950).

    Article  CAS  Google Scholar 

  • Bässler, R.: Zur Pathologie der kindlichen BrustdrĂĽsen. Beitr. path. Anat. 118, 390–406 (1957).

    Google Scholar 

  • Bässler, R.: Beiträge zur Morphologie der kindlichen BrustdrĂĽse. Frankfurt. Z. Path. 69, 37–52 (1958).

    Google Scholar 

  • Bässler, R.: Elektronenmikroskopische Beobachtungen bei experimenteller Milchstauung. Frankfurt. Z. Path. 71, 398–422 (1961).

    Google Scholar 

  • Bässler, R.: Formen der Makromastie. Beitr. path. Anat. 133, 430–460 (1966).

    Google Scholar 

  • Bässler, R.: Neuere Aspekte der normalen und pathologischen Feinstruktur der Mamma. Hippokrates (Stuttg.) 39, 237–244 (1968).

    Google Scholar 

  • Bässler, R.: Das sogenannte lobuläre Carcinom der Mamma. Dtsch. med. Wschr. 94, 108–113 (1968).

    Article  Google Scholar 

  • Bässler, R., Brethfeld, V.: Enzymhistochemische Studien an der MilchdrĂĽse. Gravidität-Laktation, Involution und experimentelle Stauung mit besonderer BerĂĽck, sichtigung myoepithelialer Zellen. Histochemie 15, 270–286 (1968).

    Article  PubMed  Google Scholar 

  • Bässler, R., Flörchinger, J.: (a) Histometrische Studien an der laktierenden MilchdrĂĽse. I. Mitteilung: Lactation und physiologische Involution. Arch. Gynäk. 203, 366–399 (1960).

    Article  Google Scholar 

  • Bässler, R., Flörchinger, J.: (b) Histometrische Studien an der lactierenden MilchdrĂĽse. II. Mitteilung: Experimentelle Milchstauung und vermehrtes FlĂĽssigkeitsangebot durch Periston-infusionen. Arch. Gynäk. 203, 400–422 (1966).

    Article  Google Scholar 

  • Bässler, R., Forssmann, W.: Experimenteller Strukturwandel der DrĂĽsenzelle durch Hormonwirkung. Verh. dtsch. Ges. Path. 48, 240–244 (1964).

    Google Scholar 

  • Bässler, R., Paek, S.: Histochemisches Enzymmuster der Mamma unter dem experimentellen EinfluĂź von Geschlechtshormonen. Histochemie 13, 29–44 (1968).

    Article  PubMed  Google Scholar 

  • Bässler, R., Schäfer, A.: Elektronenmikroskopische und experimentelle Untersuchungen zur Morphologie der Gynäkomastie. Verh. dtsch. Ges. Path. 52, 491–498 (1968).

    Google Scholar 

  • Bässler, R., Schäfer, A.: (a) Elektronenmikroskopische Cytomorphologie der Gynäkomastie. Virchows Arch. Abt. A Path Anat. 348, 356–373 (1969).

    Article  Google Scholar 

  • Bässler, R., Schäfer, A.: (b) Elektronenmikroskopische Cytomorphologie der männlichen BrustdrĂĽse. Z. Zellforsch. 101, 355–366 (1969).

    Article  PubMed  Google Scholar 

  • Bässler, R., Schäfer, A., Paek, S.: Elektronenmikroskopische und histochemische Untersuchungen zur Morphologie und Funktion myoepithelialer Zellen. Verh. dtsch. Ges. Path. 51, 301–307 (1967).

    Google Scholar 

  • Bässler, R., Schulze, G., Schriever, D.: Histochemische Untersuchungen am Bindegewebe der hormonal stimulierten Mamma. Experimentelle Beiträge zur Pathogenese von Fibrosierungen in der BrustdrĂĽse. Beitr. path. Anat. (in press).

    Google Scholar 

  • Baldwin, R. L., Martin, R. J.: Protein and nuclein acid synthesis in rat mammary glands during early lactation. Endocrinology 82, 1209–1216 (1968).

    Article  CAS  Google Scholar 

  • Balinsky, B.I.: (a) On the prenatal growth of the mammary gland rudiment in the mouse. J. Anat. (Lond.) 84, 227–235 (1950).

    CAS  Google Scholar 

  • Balinsky, B.I.: (b) On the developmental processes in mammary glands and other epidermal structures. Trans, roy. Soc. Edinb. 62, 1–31 (1956).

    Article  Google Scholar 

  • Banerjee, M. R., Walker, R. J.: Variable duration of DNA-synthesis in mammary gland cells during pregnancy and lactation of C3H/HE mouse. J. Cell Physiol. 69, 133–142 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Bardin, C. W., Liebelt, A. G., Liebelt, R. A.: The direct effect of pituitary isografts on mammary gland development in the mouse. Proc. Soc. exp. Biol. (N. Y.) 110, 716–718 (1962).

    Article  CAS  Google Scholar 

  • Bardin, C. W., Liebelt, A. G., Liebelt, R. A.: Effect of hypophysial isografts on the mammary glands of intact and hypophysectomized mice. Endocrinology 74, 586–592 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Bargmann, W., Fleischhauer, K., Knoop, A.: Ăśber die Morphologie der Milchsekretion. II. Zugleich eine Kritik am Schema der Sekretionsmorphologie. Z. Zellforsch. 53, 545–568 (1961).

    PubMed  CAS  Google Scholar 

  • Beato, M., Dienstbach, F.: Effect of estrogens and gestagens on the duration of DNA synthesis in the genital tract of ovariectomized mice. Virchows Arch. Abt. B. Zellpath. 1, 197–200 (1968).

    CAS  Google Scholar 

  • Bengtsson, B., Norgren, A.: Interactions of oestrone and testosterone on mammary glands of male rabbit. Acta endocr. (Kbh.) 36, 141–156 (1961).

    CAS  Google Scholar 

  • Benson, G. K., Cowie, A. T., Cox, C. P., Flux, D. S., Folley, S. J.: Studies on the hormonal induction of mammary growth and lactation in the goat. II. Functional and morphological studies of hormonally developed udders with special reference to the effect of “triggering” doses of oestrogen. J. Endocr. 13, 46–58 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Benson, G. K., Cowie, A. T., Cox, C. P., Flux, D. S., Folley, S. J., Folley, S. J., Hosking, Z. D.: Relative efficiency of hexoestrol and progesterone as oily solutions and as crystalline suspensions in inducing mammary growth and lactation in early and late ovariectomized goats. J. Endocr. 31, 157–164 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Benson, G. K., Cowie, A. T., Cox, C. P., Flux, D. S., Folley, S. J., Goldzweig, S.A.: Effects of oestrone and progesterone on mammary development in guinea-pig. J. Endocr. 15, 126–144 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Benson, G. K., Cowie, A. T., Folley, S. J., Tindal, J. S.: Recent developments in endocrine studies on mammary growth and lactation. In: Recent progress in the endocrinology of reproduktion (C. W. Lloyd, ed.), p. 457–490. New York: Academic Press 1959.

    Google Scholar 

  • Benson, G. K., Folley, S. J.: (a) Oxytocin as stimulator for the release of prolactin from the anterior pituitary. Nature (Lond.) 177, 700 (1956).

    Article  CAS  Google Scholar 

  • Benson, G. K., Folley, S. J.: (b) Retardation of mammary involution in the rat by oxytocin. J. Endocr. 14, 42 (1957).

    Google Scholar 

  • Benson, G. K., Folley, S. J.: (c) The effect of oxytocin on mammary gland involution in the rat. J. Endocr. 16, 189–201 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Berde, B.: Recent progress in oxytocin research. Amer. Lect. Series. Springfield, Ill.: C. C. Thomas Publ. 1959.

    Google Scholar 

  • Berde, B., Cerletti, A.: Ăśber die Wirkung pharmakologischer Oxytocindosen auf die MilchdrĂĽse. Acta endocr. (Kbh.) 34, 543–557 (1960).

    CAS  Google Scholar 

  • Berger, H.: Beitrag zur elektronenoptischen Zelldifferenzierung des soliden Mamma-carcinoms und der Mastopathia cystica des Menschen. Z. Krebsforsch. 66, 73–86 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Berk, F.: Beitrag zur Kenntnis der ersten Anlage der menschlichen BrustdrĂĽse. Med. Inaug.-Diss. Greifswald 1913.

    Google Scholar 

  • Berka, F.: Die BrustdrĂĽse verschiedener Altersstufen und während der Schwangerschaft. Frankfurt. Z. Path. 8, 203–256 (1911).

    Google Scholar 

  • Berswordt-Wallrabe, R. v.: (a) Die Hemmung der Galaktopoese der Albinomaus durch Dienöstroldiacetat und ihre Auswirkungen auf das inkretorische System. Arch. Gynäk. 190, 549–618 (1958).

    Article  CAS  Google Scholar 

  • Berswordt-Wallrabe, R. v.: (b) Versuch einer theoretischen Erklärung der Hemmung der Galaktopoese der Albinomaus durch Dienöstroldiacetat. Arch. Gynäk. 190, 619–637 (1958).

    Article  CAS  Google Scholar 

  • Berswordt-Wallrabe, R. v., Turner, C. W.: (a) Mammogenesis in ovary-thyro-parathyroidectomized rats. Proc. Soc. exp. Biol. (N. Y.) 103, 536–537 (1960).

    Article  Google Scholar 

  • Berswordt-Wallrabe, R. v., Turner, C. W.: (b) Dihydrotachysterol (AT 10) and mammogenesis in ovary-thyro-para- thyroidectomized rats. Proc. Soc. exp. Biol. (N. Y.) 104, 599–602 (1960).

    Article  CAS  Google Scholar 

  • Biedermann, K.: Das Verhalten des Genitalapparates weiblicher Ratten bei langdauernder Follikelhormonzufuhr. Arch. Gynäk. 167, 465–476 (1938).

    Article  Google Scholar 

  • Bittorf, A.: Nebennierentumor und GeschlechtsdrĂĽsenausfall beim Manne. Berl. klin. Wschr. 56, 776 (1919).

    Google Scholar 

  • Bloch, K.: Zur Pathogenese der Mammahypertrophie bei der Digitalisapplikation. Z. Kreisl.-Forsch. 50, 591–595 (1961).

    CAS  Google Scholar 

  • Böhmig, R.: (a) Die Epithelproliferationen bei der Mastopathia fibrosa cystica. Zbl. allg. Path. path. Anat. 89, 297–313 (1952).

    Google Scholar 

  • Böhmig, R.: Mastopathia fibrosa cystica. Ergebn. allg. Path. path. Anat. 45, 39–116 (1964).

    Google Scholar 

  • Boemke, F., Birkle, K.: Zur Ă„tiologie der Fibrosis mammae virilis. Klin. Wschr. 1949, 93–96.

    Google Scholar 

  • Bohle, A.: Beitrag zur Frage der Elástica-Vermehrung in Mammatumoren. Frankfurt. Z. Path. 62, 167–183 (1951).

    PubMed  CAS  Google Scholar 

  • Bottomley, A. C., Folley, S. J.: Effect of androgenic substances on growth of teat and mammary gland in immature male guinea pig. Proc. roy. Soc., London, Biol. Sci. 126, 224–241 (1939).

    Article  Google Scholar 

  • Bradley, T. R., Cowie, A. T. : (a) The effects of hypophysectomy on the in vitro metabolism of mammary gland slices from lactating rats. J. Endocr. 14, 8–15 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Bradley, T. R., Clark, P. M.: (b) The response of rabbit mammary glands to locally administered prolactin. J. Endocr. 14, 28–36 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Brandes, D., Anton, E., Barnard, S.: Lysosomes and cellular regressive changes in rat mammary gland involution. Lab. Invest. 20, 465–471 (1969).

    PubMed  CAS  Google Scholar 

  • Brandt, G.: Die experimentelle Pathomorphogenese intramammärer Verkalkungen. Inaug.-Diss. Mainz, 1968.

    Google Scholar 

  • Brandt, G., Bässler, R.: Calciphylaktische Reaktionen der Mamma. Vortrag z. Tagg der nordwestdeutschen Pathologen, Bielefeld, 11.–13. Okt. 1968. Zbl. allg. Path. path. Anat. (in press).

    Google Scholar 

  • Brandt, G., Bässler, R.: Pathomorphogenese experimenteller Verkalkungen in der weiblichen BrustdrĂĽse. Virchows Arch. Abt. A Path. Anat. 348, 139–154 (1969).

    Article  CAS  Google Scholar 

  • Bredt, H.: Ăśber Wesen und Formen der Gynäkomastie. Z. menschl. Vererb.- u. Konstit.-Lehre 17, 29–54 (1932).

    Google Scholar 

  • Bresciani, F.: DNA-synthesis in alveolar cells of the mammary gland: Acceleration by ovarian hormones. Science 146, 653–655 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Bresciani, F.: Effect of ovarian hormones on duration of DNA synthesis in cells of the C3H mouse mammary gland. Exp. Cell Res. 38, 13–32 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Broman, J.: Die Entwicklung des Menschen vor der Geburt. MĂĽnchen: J. F. Bergmann 1927.

    Book  Google Scholar 

  • Brouha, H.: Recherches sur les diverses phases du dĂ©veloppement et de l’activitĂ© de la mamelle. Arch. Biol. (Liège) 21, 459–605 (1905).

    Google Scholar 

  • Browning, H. C., White, W. D.: Local stimulation of mammary glands by pituitary or ovarian grafts in the mouse. Tex. Rep. Biol. Med. 23, 26–37 (1965).

    PubMed  CAS  Google Scholar 

  • Browning, H. C., White, W. D., Gibbs, W.: Comparative stimulation of mammary gland by pituitary isografts with or without ovarian transplants. Tex. Rep. Biol. Med., 22, No. 1, Spring (1964).

    Google Scholar 

  • Bunting, H.: The distribution of acid mucopolysaccharides in the mammalian tissues as revealed by histochemical methods. Ann. N. Y. Acad. Sci. 52, 977–982 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Burrows, H.: Pathological changes induced in the mamma by oestrogenic compounds. Brit. J. Surg. 23, 191–213 (1935/36).

    Article  Google Scholar 

  • Busch, J. P. zum: Gynäkomastie bei Hypernephrom. Dtsch. med. Wschr. 53, 323 (1927).

    Article  Google Scholar 

  • Busch, W., Merker, H.-J.: Elektronenmikroskopische Untersuchungen an menschlichen Mammacarcinomen. Virchows Arch. Abt. A Path. Anat. 344, 356–371 (1968).

    Article  Google Scholar 

  • Calov, W. L., Whyte, H. M.: Oedema and mammary hypertrophia: Toxic effect of digitalis leaf. Med. J. Aust. 41, 556–557 (1954).

    PubMed  CAS  Google Scholar 

  • Canivenc, R., Mayer, G.: Nature du facteur lutĂ©otrophic de placenta de rat. C. R. Soc. Biol. (Paris) 147, 1067–1070 (1953).

    CAS  Google Scholar 

  • Caspersson, T.: Cell growth and cell function. New York 1945.

    Google Scholar 

  • Catchpole, H. R., Lyons, W. R.: The lactation hormone of the hypophysis. Anat. Rec. 55, 48–49 (1933).

    Google Scholar 

  • Catchpole, H. R., Lyons, W. R., Regan, W. M.: Induction of lactation in heifers with the hypophyseal lactogenic hormone. Proc. Soc. exp. Biol. (N. Y.) 31, 301–303 (1933).

    Article  Google Scholar 

  • Chain, E., Duthie, E. S.: Identity of hyaluronidase and opreading factor. Brit. J. exp. Path. 21, 324–338 (1940).

    CAS  Google Scholar 

  • Chalkley, H. W.: Method for the quantitative morphologic analysis of tissues. J. nat. Cancer Inst. 4, 47–53 (1943).

    Google Scholar 

  • Chamberlin, T. L., Gardner, W. U., Allen, E.: Local responses of the sexual skin and mammary glands monkeys to cutaneus applications of estrogen. Endocrinology 28, 753–757 (1941).

    Article  CAS  Google Scholar 

  • Chamorro, A.:Action de la progesteron seule sur la glande mammaire. C. R. Soc. Biol. (Paris) 138, 453–456 (1944).

    CAS  Google Scholar 

  • Chaudhury, R. R., Walker, J. M.: Rate of disappearance of injected oxytocin from the blood. J. Physiol. (Lond.) 138, 50–61 (1957).

    Google Scholar 

  • Cheatle, G. L., Cutler, M.: Tumors of the breast. London: Ed. Arnold & Co. 1931

    Google Scholar 

  • Chen, Th. T., Johnson, R. E., Lyons, W. R., Li, C. H., Cole, D. R.: Hormonally induced mammary growth and lactation in the absence of the thyreoid. Endocrinology 57, 153–174 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Chentsov, Y., Chentsov, S.: Electron microscopy of rat mammary, glands on lactation, hormonal stimulation and in the case of postradiation fibroadenoma. Acta Un. int. Cancr. 20, 1377–1378 (1964).

    PubMed  CAS  Google Scholar 

  • Chiquoine, A. D.: The identification and electron microscopy of myoepithelial cells in the harderian gland. Anat. Rec. 132, 569–584 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Clark, B. G., Shapiro, S., Monroe, R. G.: Postthyroidectomie, hypothyroidism, hypoparathyroidism, exophthalamus and galactorrhoea with normal menstruation: metabolic response to propened. J. clin. Endocr. 16, 1245–1251 (1956).

    Article  Google Scholar 

  • Clifton, K. H., FĂĽrth, J.: Ducto-alveolar growth in mammary glands of adreno-gonadectomized male rats bearing mammatropic pituitary tumors. Endocrinology 66, 893–897 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Cole, R., Hopkins, T. R.: Maintenance of the mammary gland in hypophysecto-mized — oophorectomized rats by injection of protein. Endocrinology 71, 395–398 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Consolandi, G.: La problema de cancero gelatinoso della mamella. Lav. 1st. Anat. Univ. Perugia 6, 35–76, 119–155 (1947).

    Google Scholar 

  • Cooke, J. V.: Chorio-epithelioma of the testicle. Bull.-Johns Hopk. Hosp. 26, 215–221 (1915).

    Google Scholar 

  • Copeland, M. M.: New aspects of benign tumours of the breast. Arch. Surg. 55, 590–621 (1947).

    Article  PubMed  CAS  Google Scholar 

  • Corner, G. W.: The hormonal control of lactation. Amer. J. Physiol. 95, 43–55 (1930).

    CAS  Google Scholar 

  • Cowie, A. T.: The relative growth of the mammary gland in normal, gonadectomized and adrenalectomized rats. J. Endocr. 6, 145–147 (1949).

    Article  PubMed  CAS  Google Scholar 

  • Cowie, A. T.: Recent studies on the endocrine control of the mammary development and milk secretion. Colloq. int. Cent. nat. Rech. sci., No. 32, p. 45–57 (1951).

    Google Scholar 

  • Cowie, A. T.: The hormonal control of milk secretion. In: Milk: The mammary gland and its secretion, ed. by S. K. Kon and A. T. Cowie, vol. I. New York and London: Academic Press 1961.

    Google Scholar 

  • Cowie, A. T., Folley, S. J.: Parathyreoidectomy and lactation in the rat. Nature (Lond.) 156, 719–721 (1945).

    Article  CAS  Google Scholar 

  • Cowie, A. T., Folley, S. J.: The mammary gland and lactation. In: Sex and internal secretions, ed. by W. C. Young and G. W. Corner, vol. II, p. 590–642. Baltimore: The Williams & Wilkins Co. 1961.

    Google Scholar 

  • Cowie, A. T., Folley, S. J., Cross, B. A., Harris, G. W., Jacobsohn, D., Richardson, K. C.: Terminology for use in lactational physiology. Nature (Lond.) 168, 421 (1951).

    Article  CAS  Google Scholar 

  • Cowie, A. T., Folley, S. J., Malpress, F. H., Richardson, K. C.: Studies on the hormonal induction of mammary growth and lactation in the goat. J. Endocr. 8, 64–88 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Cowie, A. T., Lyons, W. R.: Mammogenesis and lactogenesis in hypophysectomized, ovar-ectomized, adrenalectomized rats. J. Endocr. 19, 29–32 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Cowie, A. T., Tindal, J. S., Yokoyama, A.: The induction of mammary growth in the hypophysectomized goat. J. Endocr. 34, 185–195 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Curtiss, C.: Factors influencing lobulo-alveolar development and mammary secretion in the rat. Endocrinology 45, 284–295 (1949).

    Article  PubMed  CAS  Google Scholar 

  • Cutler, M.: Benign lesion of the female breast simulating cancer. J. Amer. med. Ass. 101, 1217–1222 (1933).

    Article  Google Scholar 

  • Cutler, M.: Tumors of the breast. Philadelphia: Lippincott 1961.

    Google Scholar 

  • Daane, Th. A., Lyons, W. R.: Effect of estrone, progesterone and pituitary mammotropin on the mammary glands of castrated C3H male mice. Endocrinology 55, 191–199 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Dabelow, A.: Der Entfaltungsmechanismus der Mamma. I. Das Verhalten von Gefäßsystem und DrĂĽsenbaum während der Laktationsentwicklung der Mamma bei Maus, Ratte, Meerschweinchen und Kaninchen. Morph. Jb. 73, 69–99 (1934).

    Google Scholar 

  • Dabelow, A.: Vergleichende Untersuchungen zur Entwicklung einiger DrĂĽsen, ihrer Gefäßbäume und ihrem Verhalten zum umgebenden Gewebe. Verh. an at. Ges. (Jena), p. 165–188 (1934).

    Google Scholar 

  • Dabelow, A.: Der Entfaltungsmechanismus der Mamma. II. Die postnatale Entwicklung der menschlichen MilchdrĂĽse und ihre Korrelationen. Morph. Jb. 85, 361–416 (1941).

    Google Scholar 

  • Dabelow, A.: Die MilchdrĂĽse. In: Handbuch der mikroskopischen Anatomie des Menschen, hrsg. von W. v. Moellendorff u. W. Bargmann, Haut- und Sinnesorgane, Ergänz, zu Bd. 3/1, S. 277ff. Berlin-Göttingen-Heidelberg: Springer 1957.

    Google Scholar 

  • Damm, H. C., Turner, C. W.: Effects of anterior pituitary preparations on mammary gland growth in mouse. Prox. Soc. exp. Biol. (N. Y.) 107, 893–895 (1961).

    Article  CAS  Google Scholar 

  • Danowski, T. S.: Clinical endocrinology, vol. I. Baltimore: The Williams & Wilkins Comp. 1962.

    Google Scholar 

  • Dawson, E. K.: Carcinoma in the mammary lobule and its origin. Edinb. med. J. 40, 57–60 (1933).

    Google Scholar 

  • Dellweg, H.: Antibiotica und Hormone — ihre Wirkung auf die Biosynthese von Nucleinsäuren und Proteinen. In: Molekularbiologie, hrsg. von T. Wieland und G. Pfleiderer, S. 83–94. Frankfurt/M.: Umschau Verlag 1967.

    Google Scholar 

  • Dempsey, E. A., Bunting, H., Wislocki, G. B.: Observations on the chemical cytology of the mammary gland. Amer. J. Anat. 81, 309–341 (1947).

    Article  PubMed  CAS  Google Scholar 

  • Desclin, L.: (a) L’ocytocine peut — elle dĂ©clencher la libĂ©ration de lutĂ©otrophine hypophysäre chez la rat? C. R. Soc. Biol. (Paris) 150, 1489–1491 (1956).

    CAS  Google Scholar 

  • Desclin, L.: (b) Hypothalamus et libĂ©ration d’hormone lutĂ©otrophique. ExpĂ©riences de greffe hypophysaire chez la rat hypophysectomisĂ©e. Action lutĂ©otrophique de l’ocytocine. Ann. Endocr. (Paris) 17, 586–595 (1956).

    CAS  Google Scholar 

  • Diczfalusy, E., Tillinger, K. G., Westman, A.: Studies on oestrogen metabolism in new born boys. I and II. Acta endocr. (Kbh.) 26, 303–312 and 313–321 (1957).

    CAS  Google Scholar 

  • Dieckmann, H.: Ăśber die Histologie der BrustdrĂĽse bei gestörtem und ungestörtem Menstruationsablauf. Virchows Arch. path. Anat. 256, 321–356 (1925).

    Google Scholar 

  • Djojosoebagio, S., Turner, C. W.: (a) The effect of crystalline dihydrotachysterol on milk secretion in thyroparathyreoidectomized lactating rats. Proc. Soc. exp. Biol. (N. Y.) 116, 909–912 (1964).

    Article  CAS  Google Scholar 

  • Djojosoebagio, S., Turner, C. W.: (b) Effects of parathyreoid extract calciferol, hytakerol and crystalline dihydrotachysterol on feed consumption in normal lactating rats. Proc. Soc. exp. Biol. (N. Y.) 116, 646–648 (1964).

    Article  CAS  Google Scholar 

  • Djojosoebagio, S., Turner, C. W.: (c) Effects of parathyreoid extract, dihydrotachysterol (hytakerol) and calciferol on milk secretion in rats. Endocrinology 74, 554–558 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Donovan, B. T., Jacobsohn, D.: Testosterone and the growth of mammary glands and other tissues of hypophysectomized rats treated with thyroxine, insulin and cortisone. Acta endocr. (Kbh.) 33, 214–229 (1960).

    CAS  Google Scholar 

  • Dorfman, R. I., Shipley, R. A.: In: Androgens. New York: J. Wiley & Son 1956.

    Google Scholar 

  • Dubois, J.: MĂ©thode d’évolution quantitative du dĂ©velopement de la glande mammaire chez la souris traitĂ©e par des corps oestrogènes. C. R. Soc. Biol. (Paris) 138, 149–151 (1944).

    CAS  Google Scholar 

  • Dumont, J. N.: Prolactin — induced cytologie changes in the mucosa of the pigeon crop during crop-“milk” formation. Z. Zeilforsch. 68, 755–782 (1965).

    Article  CAS  Google Scholar 

  • Duran-Reynals, F., Bunting, H., Wagenen, G. van: Studies on the sex skin of Macaca mulatta. Ann. N. Y. Acad. Sci. 52, 1006–1014 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Eggeling, H. von: Die MilchdrĂĽse. In: Handbuch der mikroskopischen Anatomie des Menschen von v. Moellendorf, W. Bd. 1, Berlin: Springer 1927.

    Google Scholar 

  • Eisen, M. J.: The occurence of benign and melignant mammary lesions in rats treated with crystalline estrogene. Cancer Res. 2, 632–644 (1942).

    CAS  Google Scholar 

  • Eisenfeld, A. J., Axelrod, J.: Selectivity of estrogen distribution in tissues. J. Pharmacol, exp. Ther. 150, 469–475 (1965).

    CAS  Google Scholar 

  • Elger, W., Berswordt-Wallrabe, R. von, Neumann, F.: Der EinfluĂź von Antiandrogenen auf an drogenabhängige Vorgänge im Organismus. Naturwissenschaften 54, 549–552 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Elger, W., Neumann, F.: The role of androgens in differentiation of the mammary gland in male mouse fetuses. Proc. Soc. exp. Biol. (N.Y.) 123, 637–640 (1966).

    Article  CAS  Google Scholar 

  • Ellis, R.: Fine structure of the myoepithelium of the eccrine sweat glands of man. J. Cell Biol. 27, 551–563 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Emge, L. A.: Estrogenic hormones and carcinogenesis. Surg. Gynec. Obstet. 68, 472–479 (1939).

    Google Scholar 

  • Eskin, B. A., Bartuska, D. G., Dunn, M. R., Jacob, G., Dratman, M. D.: Mammary gland dysplasie in iodine deficiency studies in rats. J. Amer. med. Ass. 200, 691–695 (1967).

    Article  CAS  Google Scholar 

  • Fauvet, E.: Vergleichende Untersuchungen ĂĽber die Entwicklung und Funktion der MilchdrĂĽsen. V. Experimentelle Untersuchungen ĂĽber den EinfluĂź der Ovarial-hormone auf die MilchdrĂĽsen der Ratten. Arch. Gynäk. 170, 244–262 (1940).

    Article  CAS  Google Scholar 

  • Ferguson, D. J., Visscher, M. B.: The effects of androgen and estrogen in castrated and hypophysectomized C3H mice. Endocrinology 52, 463–473 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Ferguson, D. J., Endocrine control of mammary glands in C3H mice. Surgery 39, 30–36 (1956).

    PubMed  CAS  Google Scholar 

  • Ferreri, F. L., Griffith, D. R.: Effect of hydrocortisone acetate on mammary gland nucleic content of pregnant rats. Proc. exp. Soc. Biol. (N.Y.) 130, 1216–1218 (1969).

    Article  CAS  Google Scholar 

  • Fischer, R., Schaefer, H. E.: Geschlechtsdifferentes Vorkommen und östrogenabhängige Induktion der alkalischen Phosphatase in subkutanen Fibroblasten der Maus. Naturwissenschaften 54, 342–343 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Fiske, S. W. C., Courtecuisse, V., Haguenau, F.: High resolution autoradiographic study of normal lactating mammary gland and mammary tumors of the mouse: Preliminary report. J. nat. Cancer Inst. 39, 209–229 (1967).

    PubMed  CAS  Google Scholar 

  • Flux, D. S. : (a) Effect of 17-Vinyltestosterone on the mammae, uteri, thymus an adrenal glands of spayed female mice. Proc. S.c. exp. Biol. (N. Y.) 85, 16–18 (1954).

    Article  CAS  Google Scholar 

  • Flux, D. S.: (b) The effect of adrenal steroids on the growth of the mammary glands, uteri, thymus and adrenal glands of intact, ovariectomized and oestrone-treated ovariectomized mice. J. Endocr. 11, 238–254 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Flux, D. S.: Mammary gland growth in male mice of the CHI strain after hypophysectomy and castration. J. Endocr. 17, 300–306 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Flux, D. S.: Munford, R. E.: The effect of adrenocorticotropin on the mammary glands of intact nature female mice of the Chi strain. J. Endocr. 14, 343–347 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Folley, S. J.: Lactation. Biol. Rev. 15, 421–458 (1940).

    Article  CAS  Google Scholar 

  • Folley, S. J.: The physiology and biochemistry of lactation. Edinburgh and London: Oliver & Boyd 1956.

    Google Scholar 

  • Folley, S. J.: (a) Endocrine control of the mammary gland. Mammary development. Brit. med. Bull. 5, 130–134 (1947).

    CAS  Google Scholar 

  • Folley, S. J.: (b) Lactation. Brit. med. Bull. 5, 135–141 (1947).

    CAS  Google Scholar 

  • Folley, S. J.: Some effects of steroids on the mammary gland. In: Ciba foundation Colloquia on Endocrinology, ed. by G. E. W. Wolstenholme, vol. I, p. 69–86. London: J. & A. Churchill 1952.

    Google Scholar 

  • Folley, S. J.: Hormones in mammary and function. Brit. med. Bull. 11, 145–150 (1955).

    PubMed  CAS  Google Scholar 

  • Folley, S. J., Greenbaum, A. L.: Changes in the arginase and alkaline phosphatase contents of the mammary gland and liver of the rat during pregnancy, lactation and mammary involution. Biochem. J. 41, 261–269 (1947).

    PubMed  CAS  Google Scholar 

  • Folley, S. J., Gutkelch, A. N., Zuckerman, S.: The mammary gland of the rhesus monkey and normal and experimental conditions. Proc. roy. Soc., London, Biol. Sci. 126, 469–491 (1939).

    Article  CAS  Google Scholar 

  • Folley, S. J., McNaught, M. L.: Biosynthesis of milkfat. In: Milk, the mammary gland and its secretion, ed. by S. K. Kon and A. T. Cowie, vol. 1, p. 441–479. New York and London: Academic Press 1961.

    Google Scholar 

  • Folley, S. J., Young, F. G.: Prolactin as a specific lactogenic hormone. Lancet 1941, 380–381.

    Google Scholar 

  • Foote, F. W., Stewart, F. W.: Lobular carcinoma in situ. A rare form of mammary cancer. Amer. J. Path. 17, 491–496 (1941).

    PubMed  CAS  Google Scholar 

  • Foote, F. W., Stewart, F. W.: Comparative studies of cancerous versus noncancerous breasts. Ann. Surg. 121, 197–222 (1945).

    Article  PubMed  CAS  Google Scholar 

  • Forbes, A. P., Henneman, P. H., Griswold, G. C., Albright, F.: A syndrome, distinct from acromegaly, characterized by spontaneous lactation, amenorrhea, and low folliclestimulating hormone excretion. J. clin. Endocr. 11, 749 (1951).

    Article  Google Scholar 

  • Forbes, A. P., Henneman, P. H., Griswold, G. C., Albright, F.: Syndrome characterized by galactorrhoea, amenorrhoea and low urinary FSH: Comparison with acromegaly and normal lactation. J. clin. Endocr. 14, 265–271 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Forbes, Th. R.: Factor of age in the rate of absorption of, and in mammary stimulation by, testosterone monopropionate pellets in rats. Endocrinology 30, 765–766 (1942).

    Article  CAS  Google Scholar 

  • Forssmann, W. G.: Elektronenmikroskopische Morphologie der Sekretion des Tauben-kropfes unter dem EinfluĂź von Prolaktin. Frankfurt. Z. Path. 74, 512–533 (1965).

    PubMed  CAS  Google Scholar 

  • Forsyth, J. A., Folley, S. J., Chadwick, A.: Lactogenic and pigeon crop-stimulating activities of human pituitary growth hormone preparations. J. Endocr. 31, 115–126 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Frantz, V. K., Pickren, J. W., Melcher, G. W., Auchincloss, H.: Incidence of chronic cystic disease in so called “normal breasts”. Cancer (Philad.) 4, 762–783 (1951).

    Article  CAS  Google Scholar 

  • Frazier, C. N., Mu, J. W.: Development of female characteristics in adult male rabbits following prolonged administration of extrogenic substance. Proc. Soc. exp. Biol. (N. Y.) 32, 997–1001 (1935).

    Article  Google Scholar 

  • Gardner, W. U.: Growth of the mammary glands in hypophysectomized mice. Proc. Soc. exp. Biol. (N. Y.) 45, 835–837 (1940).

    Article  CAS  Google Scholar 

  • Gardner, W. U.: Inhibition of mammary growth by large amounts of estrogen. Endocrinology 28, 53–61 (1941).

    Article  CAS  Google Scholar 

  • Gardner, W. U., Smith, G. M., Strong, L. C.: Stimulation of abnormal mammary growth by large amounts of estrogenic hormone. Proc. Soc. exp. Biol. (N. Y.) 33, 148–150 (1935).

    Article  Google Scholar 

  • Gardner, W. U., Strong, L. C.: The normal development of the mammary glands of virgin female mice of ten strains varying in susceptibility to spontaneous neoplasma. Amer. J. Cancer 25, 282–290 (1935).

    Article  Google Scholar 

  • Gardner, W. U., Turner, C. W.: The function, assay, and preparation of galactin, a lactation stimulating hormone of the anterior pituitary. Missouri Agr. Exp. Sta. Res. Bull. 190 (1933).

    Google Scholar 

  • Gardner, W. U., White, A.: Mammary growth in hypophysectomized male mice receiving estrogen and prolactin. Proc. Soc. exp. Biol. (N. Y.) 48, 590–592 (1941).

    Article  CAS  Google Scholar 

  • Garrett, F. A., Talmage, R. V.: The influence of relaxin on mammary gland development in guinea-pigs and rabbits. J. Endocr. 8, 336–340 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Geschickter, C. F.: The endocrine aspects of chronic cystic mastitis. Sth. Surg. 10, 457–486 (1941).

    Google Scholar 

  • Geschickter, C. F.: Diseases of the breast, 2nd ed. Philadelphia-London-Montreal: Lippincott 1948.

    Google Scholar 

  • Geschickter, C. F., Byrnes, E. W.: Factors influencing the development and time of appearance of mammary cancer in the rat in response to estrogen. Arch. Path. 33, 335–342 (1942).

    Google Scholar 

  • Geschickter, C. F., Hartman, C.G.: Mammary response to prolonged estrogenic stimulation in the monkey. Cancer (Philad.) 12, 767–781 (1959).

    Article  CAS  Google Scholar 

  • Geschickter, C. F., Speert, H.: Zit. nach Speert, 1948.

    Google Scholar 

  • Girardie, J., Wolff, E.: Localisation optique et ultrastructurale de l’activitĂ© phosphatasique alcaline dans TepithĂ©lium mammaire. C. R. Acad. Sci. (Paris) 264, 2064–2067 (1967).

    CAS  Google Scholar 

  • Glock, G. E., McLean, P.: Further studies on the properties and assays of glucose- 6-phosphate-dehydrogenase and 6-phospho-gluconate-dehydrogenase of rat liver. Biochem. J. 55, 400–408 (1954).

    Google Scholar 

  • Glock, G. E., McLean, P.: Levels of enzymes of the direct oxydative pathway of carbohydrate metabolism in mammalian tissues and tumors. Biochem. J. 56, 171–175 (1954).

    PubMed  CAS  Google Scholar 

  • Gögl, H., Lang, F. J.: BrustdrĂĽse. In: Lehrbuch der spez. pathologischen Anatomie von E.Kaufmann, hrsg. von M. Staemmler, 11./12. Aufl., II. Bd., l.Teil. Berlin: W. D. Gruyter & Co. 1957.

    Google Scholar 

  • Gössner, W.: Histochemischer Nachweis hydrolytischer Enzyme mit Hilfe der Azo- farbst off mĂ©thode. Histochemie 1, 48–96 (1959).

    Google Scholar 

  • Goldenberg, V. E., Wiegenstein, L., Mottet, N. K.: Florid breast fibroadenomas in patients taking hormonal oral contraceptives. Amer. J. clin. Path. 49, 58–59 (1968).

    Google Scholar 

  • Gomez, E. T., Turner, C. W.: Hypophysectomy and replacement therapy in relation to the growth and secretory activity of the mammary gland. Res. Bull. Mo. agrie. Exp. Sta. Nr. 259 (1937).

    Google Scholar 

  • Gorski, J., Noteboom, W. D., Nicolette, J. A.: Estrogen control of the synthesis of RNA and protein in the uterus. J. cell. comp. Physiol. 66, 91–110 (1965).

    Article  CAS  Google Scholar 

  • Graumann, W.: (a) Entwicklung des Milchstreifens. Z. Anat. Entwickl.-Gesch. 114, 500–510 (1950).

    Article  Google Scholar 

  • Graumann, W.: (b) Mikroskopische Anatomie der männlichen BrustdrĂĽse. 1. Kindheit und Pubertät. Z. mikr.-anat. Forsch. 59, 358–380 (1952).

    Google Scholar 

  • Graumann, W.: (c) Mikroskopische Anatomie der männlichen BrustdrĂĽse. 2. Mannesalter und Senium. Z. mikr.-anat. Forsch. 59, 523–557 (1953).

    CAS  Google Scholar 

  • Green, J. D., Harris, G. W.: The neurovascular link between the neurohypophysis and adenohypophysis. J. Endocr. 5, 136–145 (1946/48).

    Article  Google Scholar 

  • Greenbaum, A. L., Slater, T. F.: Studies on the particulate components of rat mammary gland. II. Changes in the levels of the nucleic acids of the mammary glands of rats during pregnancy, lactation and mammary involution. Biochem. J. 66, 155–161 (1957).

    PubMed  CAS  Google Scholar 

  • Gregg, W. I.: Galactorrhoea after contraceptive hormones. New Engl. J. Med. 274, 1432–1434 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Griffith, D. R., Turner, C. W.: Desoxyribonucleic acid (DNA) content of mammary gland during pregnancy and lactation. Proc. Soc. exp. Biol. (N.Y.) 95, 347–348 (1957).

    Article  CAS  Google Scholar 

  • Griffith, D. R., Turner, C. W.: Normal growth of rat mammary glands during pregnancy and lactation. Proc. Soc. exp. Biol. (N.Y.) 102, 619–621 (1959).

    Article  CAS  Google Scholar 

  • Griffith, D. R., Turner, C. W.: (a) Normal growth of rat mammary glands during pregnancy and early lactation. Proc. Soc. exp. Biol. (N.Y.) 106, 448–451 (1961).

    Article  CAS  Google Scholar 

  • Griffith, D. R., Turner, C. W.: (b) Thyroxine and mammary gland growth in rat. Proc. Soc. exp. Biol. (N.Y.) 106, 873–874 (1961).

    Article  CAS  Google Scholar 

  • Griffith, D. R., Turner, C. W.: (c) Normal and experimental involution of rat mammary gland. Proc. Soc. exp. Biol. (N. Y.) 107, 668–670 (1961).

    Article  CAS  Google Scholar 

  • Grosvenor, C.E., Turner, C. W.: (a) Evidence for adrenergic and cholinergic components in milk let down reflex in lactating rats. Proc. Soc. exp. Biol. (N. Y.) 95, 719–722 (1957).

    Article  CAS  Google Scholar 

  • Grosvenor, C.E., Turner, C. W.: (b) Release and restoration of pituitary lactogen in response to nursing stimuli in lactating rats. Proc. Soc. exp. Biol. (N. Y.) 96, 723–725 (1957).

    Article  CAS  Google Scholar 

  • Gruber, G. B.: Ăśber die MilchdrĂĽsenschwellung bei Neugeborenen. Z. Kinderheilk. 30, 336–362 (1921).

    Article  Google Scholar 

  • Grumbrecht, P.: Pathologische Auswirkungen des Follikelhormones. Arch. Gynäk. 170, 1–59 (1941).

    Article  Google Scholar 

  • Haagensen, C. D.: Diseases of the breast. Philadelphia: W. B. Saunders 1956.

    Google Scholar 

  • Habbe, K.: Beitrag zur Frage ĂĽber Granulosazelltumoren. Zbl. Gynäk. 55, 1088 (1931).

    Google Scholar 

  • Hadfield, D.: The nature and origin of the mammotrophic agent present in human female urine. Lancet 1957 I, 1058–1061.

    Article  Google Scholar 

  • Hadfield, D., Young, S.: The controlling influence of the pituitary on the growth of the normal breast. Brit. J. Surg. 46, 265–273 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Haenel, H.: Ein Fall von dauernder Milchsekretion beim Manne. MĂĽnch. med. Wschr. 75, 261–263 (1928).

    Google Scholar 

  • Haguenau, F.: (a) Le cancer mammaire de la souris et de la femme Ă©tude comparative au microscope Ă©lectronique. Path, et Biol. 7, 989–1015 (1959).

    CAS  Google Scholar 

  • Haguenau, F.: (b) zLes myofilaments de la cellule myoepithelial. Etude au microscope Ă©lectronique. C. R. Acad. Sci. (Paris) 249, 182–184 (1959).

    CAS  Google Scholar 

  • Haguenau, F., Arnoult, J.: (c) Le cancer du sein chez la femme. Bull. Ass. franç. Cancer 46, 177–211 (1959).

    PubMed  CAS  Google Scholar 

  • Hamada, H., Neumann, F., Junkmann, K.: Intrauterine antimaskuline Beeinflussung von Rattenfeten durch ein stark gestagen wirksames Steroid. Acta endocr. (Kbh.) 44, 380–388 (1963).

    CAS  Google Scholar 

  • Hamberger, L., AhrĂ©n, K.: Influence of the adrenal cortex on growth processes in the rat mammary gland. J. Endocr. 30, 171–179 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Hamperl, H.: Ăśber die Myothelien (myo-epitheliale Elemente) der BrustdrĂĽse. Virchows Arch. path. Anat. 305, 171–215 (1940).

    Google Scholar 

  • Hancock, J., Brumby, P. J., Turner, C. W.: Hormonal induction of lactation in identicaltwin dairy cattle. N. Z. J. Sci. Tech. A, 36, 111–116 (1954).

    Google Scholar 

  • Hansen, R. G., Carlson, D.M.: General biochemistry of mammary tissue. In: Milk, the mammary gland and its secretion, ed. by S. K. Kon and A. T. Cowie, vol. 1, p. 371–388. New York and London: Academic Press 1961.

    Google Scholar 

  • Hardy, M. H.: The Development in vitro of the Mammary Glands of the mouse. J. Anat. (Lond.) 84, 388–393 (1950).

    CAS  Google Scholar 

  • Hartmann, M.: EinfĂĽhrung in die allgemeine Biologie. Sammlung Göschen, Sammlung Bd. 96, 1956.

    Google Scholar 

  • Hayashida, T.: Further observations on the question of specificity of antihuman growth hormone rabbit serum. Endocrinology 70, 846–856 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Helminen, H. J., Ericsson, L. E., Orrenius, S.: Studies on the mammary gland involution. IV. Histochemical and biochemical observations on alterations in lysosomes and lysosomal enzymes. J. Ultrastruct. Res. 25, 240–252 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Herold, L., Effkemann, G.: Beziehungen des Follikelhormons zu patho-physio-logischen Wachstumsvorgängen der BrustdrĂĽse. Arch. Gynäk. 163, 85–93, 94–101, 309–315 (1936).

    Article  Google Scholar 

  • Heuverswyn, J. van, Folley, S. J., Gardner, W. U.: Mammary growth in male mice receiving androgens, estrogens and desoxycorticosterone acetate. Proc. Soc. exp. Biol. (N. Y.) 41, 389–392 (1939).

    Article  Google Scholar 

  • Hibbs, R. G.: The fine structure of the human eccrine sweat glands. Amer. J. Anat. 103, 201–218 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Higashi, K.: Studies on the prolactin-like substance in human placenta. Endocrin. Jap. 9, 1–11 (1962).

    CAS  Google Scholar 

  • Higuchi, K.: Die Gewebsmastzellen in der Mamma. Fol. haemat. (Lpz.) 40, 401–414 (1930).

    Google Scholar 

  • Höhn, E. O.: The effect of oestrone on the mammary gland of adrenalectomized guinea-pigs. J. Endocr. 16, 227–230 (1957).

    Article  PubMed  Google Scholar 

  • Hoffmann, F.: Ăśber die Wirkung des Follikelhormons auf den histologischen Aufbau der menschlichen BrustdrĂĽse. Zbl. Gynäk. 63, 422–426 (1939).

    CAS  Google Scholar 

  • Holmes, R.: Alkaline phosphatase in the rabbit mammary gland. Nature (Lond.) 178, 311 (1956).

    Article  CAS  Google Scholar 

  • Holzner, J. H., Kaufmann, F.: Histochemische Untersuchungen ĂĽber das Verhalten der Phosphatasen bei der zyklischen Mastopathie, beim Fibroadenom und Karzinom der menschlichen BrustdrĂĽse. Krebsarzt 20, 185–192 (1965).

    PubMed  CAS  Google Scholar 

  • Hoshino, K.: Development and growth of mammary glands of CBA mice prenatally exposed to progesterone. Anat. Rec. 154, 360 (1966).

    Google Scholar 

  • Hughes, E. S. R.: The Development of the Mammary Gland. Ann. roy. Coll. Surg. Eng. 6, 99–119 (1950).

    PubMed  CAS  Google Scholar 

  • Humboldt, A. v.: Aus: Reise in die Aequinoktialgegenden. Ges. Werke, Stuttgart, Bd. 5, S. 230 (1889).

    Google Scholar 

  • Humphrey, L. J., Swedlow, M.: The relationship of breast disease to thyroid disease. Cancer (Philad.) 17, 1170–1173 (1964).

    Article  CAS  Google Scholar 

  • Hunter, J.: Observation on certain parts of the animal occonomy, p. 191–198: On a secretion in the crop of breeding pigeons, for the nourishment of their young. London 1786.

    Google Scholar 

  • Ihnen, M., Perez-Tamayo, R.: Breast stroma; morphological and histochemical study. Arch. Path. 56, 46–67 (1953).

    CAS  Google Scholar 

  • Ingleby, H.: Normal and pathologic proliferation in the breast with special reference to cystic disease. Arch. Path. 33, 573–589 (1942).

    Google Scholar 

  • Jacobsohn, D.: Action of estradiol monobenzoate on the mammary glands of hypo-physectomized rabbits. Acta physiol. scand. 32, 304–313 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Jacobsohn, D.: Thyroxin and the reaction of the mammary glands to ovarian steroids in hypo-physectomized rats. J. Physiol. (Proc. Physiol. Soc.) 148, 10–11 (1959).

    Google Scholar 

  • Jacobsohn, D.: Effects of thyroxine on growth of mammary glands, whole body, heart and liver in hypophysectomized rats treated with Insulin, Cortisone and ovarian steroids. Acta endocr. (Kbh.) 35, 107–134 (1960).

    CAS  Google Scholar 

  • Jacobsohn, D.: Hormonal Regulation of Mammary Gland growth. In: Milk: The mammary gland and its secretion by Kon, S. K. and A. T. Cowie, vol. 1, p. 127–160. New York and London: Academic Press 1961.

    Google Scholar 

  • Jacobsohn, D.: Modification by oestrogens of the reaction of the rat’s mammary gland to androgens. Acta endocr. (Kbh.) 41, 88–100 (1962).

    CAS  Google Scholar 

  • Jacobsohn, D.: Norgren, A.: Estrogens and corticoids in relation to mammary gland growth in male rats. Proc. Soc. exp. Biol. (N. Y.) 118, 1106–1109 (1965).

    Article  CAS  Google Scholar 

  • Jakobovits, A.: Extrapuerperale Milchabsonderung nach Kastration. Zbl. Gynäk. 82, 438–441 (1960).

    CAS  Google Scholar 

  • Jeffers, K. R.: Cytology of the mammary gland of the albino rat. I. Pregnancy, lactation and involution. Amer. J. Anat. 56, 257–277 (p 35).

    Google Scholar 

  • Jensen, E. V., Jacobson, H. J.: Basii guides to the mechanism of oestrogen action. Recent Progr. Hormone Res. 18, 387–414 (1962).

    CAS  Google Scholar 

  • Jervell, K. J., Diniz, C. R., Mueller, G. C.: Early effects of estradiol on nuclei acid metabolism in the rat uterus. J. biol. Chem. 231, 945–948 (1958).

    PubMed  CAS  Google Scholar 

  • Johnson, R. M.: The effects of cortisone on lactation in rats. J. Anim. Sci. 15, 1288 (1956).

    Google Scholar 

  • Jacobsohn, D.: Effects of cortisone on lactation and involution of mammary glands in rats. J. Dairy Sci. 40, 625 (1957).

    Google Scholar 

  • Jacobsohn, D., Meites, J.: Effects of cortisone, hydrocortisone and ACTH on mammary growth and pituitary prolactin content of rats. Proc. Soc. exp. Biol. (N. Y.) 89, 455–458 (1955).

    Article  Google Scholar 

  • Jones, D. B.: Florid papillomatosis of the nipple ducts. Cancer (Philad.) 8, 315–319 (1955).

    Article  CAS  Google Scholar 

  • Josimovich, J. B., McLaren, J. A.: Presence in the human placenta and their serum of a highly lactogenic substance immunologically related to pituitary growth hormone. Endocrinology 71, 209–220 (1952).

    Article  Google Scholar 

  • Junkmann, K.: Die physiologische Chemie der inneren Sekretion. In: Flaschen-träger-Lehnartz, Handbuch der physiologischen Chemie, Bd. II. Der Stoffwechsel, 2. Teil/Bandteil 6, S. 485–488. Berlin-Göttingen-Heidelberg: Springer 1957.

    Google Scholar 

  • Junkmann, K., Neumann, F.: Zum Wirkungsmechanismus von an Feten antimaskulin wirksamen Gestagenen. Acta endocr. (Kbh.) Suppl. 90, 139–154 (1964).

    CAS  Google Scholar 

  • Karlson, P.: Biochemische Wirkungsweise der Hormone. Dtsch. med. Wschr. 86, 668–674 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Junkmann, K.: Morphogenese und Metamorphose der Insekten. 13. Colloquium Ges. physiol. Chemie, S. 101–126 (1962).

    Google Scholar 

  • Junkmann, K.: Chemie und Biochemie der Insektenhormone. Angew. Chemie 75, 257–265 (1963).

    Article  Google Scholar 

  • Karsner, H. T.: Gynecomastia. Amer. J. Path. 22, 235–315 (1946).

    Google Scholar 

  • King, R. J. B., Gordon, J., Inman, D. R.: The intracellular localization of oestrogen in rat tissues. J. Endocr. 32, 9–15 (1965).

    Article  PubMed  CAS  Google Scholar 

  • King, R. J. B., Gordon, J., Cowan, D. M., Inman, D. R.: The intranuclear localization of 6,7-3H oestradiol-17-α in dimethyl-benzanthracen-induced. Rat mammary adenocarcinoma and other tissue. J. Endocr. 36, 139–150 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Kirkham, W. R., Turner, C. W.: Nucleic acids of the mammary glands of rats. Proc. Soc. exp. Biol. (N.Y.) 83, 123–126 (1953).

    Article  CAS  Google Scholar 

  • Kirkham, W. R., Turner, C. W.: Introduction of mammary growth in rats by estrogen and progesterone. Proc. Soc. exp. Biol. (N. Y.) 87, 139–141 (1954).

    Article  CAS  Google Scholar 

  • Rocharian, C.D.: Regulation of ribonucleic acid biosynthesis in the mouse kidney by androgens. Proc. 2nd Internat. Congr. on Hormonal Steroids, 1967, p. 794–802.

    Google Scholar 

  • Koelliker, A.: Mikroskopische Anatomie oder Gewebelehre des Menschen, 2 Bd. Spezielle Gewebelehre. Leipzig. Engelmann 1852.

    Google Scholar 

  • Kon, S. K., Cowie, A. T.: Milk. The mammary gland and its secretion, vol. I. u. II. New York and London: Academic Press 1961.

    Google Scholar 

  • Konjetzny, G. E.: Pathologie, Klinik und Behandlung der Mastopathie. Stuttgart 1942.

    Google Scholar 

  • Konjetzny, G. E.: Mastopathie und MilchdrĂĽsenkrebs. Stuttgart: Enke Verlag 1954.

    Google Scholar 

  • Kracht, J., Hachmeister, M., Breustedt, H.-J., Zimmermann, H.-D.: Immun-histologische Hormonlokalisation im Hypophysenvorderlappen des Menschen. Materia Medica Nordmark XIX/ 4, 224–238 (1967).

    Google Scholar 

  • Kraus, E. J.: Zur Pathogenese der Galaktorrhoe. Arch. Gynäk. 159, 380–394 (1935).

    Article  CAS  Google Scholar 

  • Kueckens, H.: Zur Frage der zyklischen Veränderungen der Mamma und des menschlichen Scheidenepithels. Z. Geburtsh. 96, 55–76 (1929).

    Google Scholar 

  • Kunert, J.: Die Wirkung hoher Dosen örtlich verabreichten Follikelhormons auf die männliche BrustdrĂĽse und das endokrine System. Experimentelle Studie zum Gynäkomastieproblem. Frankfurt. Z. Path. 62, 373–383 (1951).

    PubMed  CAS  Google Scholar 

  • Kuru, H.: Beiträge zur Geschwulstlehre. Dtsch. Z. Chir. 98, 414–463 (1909).

    Article  Google Scholar 

  • Kuzma, J. F.: Myoepithelial proliferations in the human breast. Amer. J. Path. 19, 473–489 (1943).

    PubMed  CAS  Google Scholar 

  • Labhart, A.: Klinik der inneren Sekretion. Berlin-Göttingen-Heidelberg: Springer 1957.

    Book  Google Scholar 

  • Langer, E., Huhn, S.: Der submikroskopische Bau der Myoepithelzelle. Z. Zellforsch. 47, 507–516 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Lani, K.: Enzymhistochemische und morphologische Untersuchungen ĂĽber die Prolaktinwirkung auf die Mamma. Inaug.-Diss. Mainz 1967.

    Google Scholar 

  • Lani, K., Bässler, R.: Tagg der nord- und westdeutschen Pathologen in LĂĽneburg 1967. Zbl. allg. Path. path. Anat. 111, 473 (1968).

    Google Scholar 

  • Laqueur, E., de Jongh, S. E.: Zur Wirkung des weiblichen Sexualhormons Men-formon, im besonderen auf die Mamma. Mschr. Geburtsh. 80, 245 (1928).

    Google Scholar 

  • Laqueur, G. L.: Effects of testosterone propionate on the mammary glands of female albino rats. Endocrinology 32, 81–86 (1943).

    Article  CAS  Google Scholar 

  • Laqueur, G. L., Fluhmann, C. F.: Effects of testosterone propionate in immature and adult female rats. Endocrinology 30, 93–101 (1942).

    Article  CAS  Google Scholar 

  • Lauritzen, C.: Oestrogerne und Gestagene beim Menschen. Naturw. Rdsch. 18, 7–16 (1965).

    CAS  Google Scholar 

  • Leeson, R.: (a) The histochemical identification of myoepithelium with particular reference to the Harderian and exorbital lacrimal glands. Acta anat. (Basel) 40, 87–94 (1960).

    Article  CAS  Google Scholar 

  • Leeson, R.: (b) The elctron microscopy of the myoepithelium in the rat exorbital lacrimal gland. Anat. Rec. 137, 45–55 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Leonard, S. L.: Stimulation of mammary glands in hypophysectomized rats by estrogen and testosterone. Endocrinology 32, 229–237 (1943).

    Article  CAS  Google Scholar 

  • Leonard, S. L., Reece, R.P.: The relation of the thyroid to mammary gland growth in the rat. Endocrinology 28, 65–69 (1941).

    Article  CAS  Google Scholar 

  • Leonard, S. L., Reece, R.P.: Failure of steroid hormones to induce mammary growth in hypophysectomized rats. Endocrinology 30, 32–36 (1942).

    Article  CAS  Google Scholar 

  • Letterer, E.: Die Morphologie der hormonalbedingten Veränderungen des Endometriums und der weiblichen BrustdrĂĽse. Ă„rztl. Wschr. 1948, 230–236.

    Google Scholar 

  • Leuschner, U.: Ăśber die Lokalisation von Mucopolysacchariden und Mastzellen in scirrhösen Karcinomen der Mamma. Acta histochem. (Jena) 34, 126–137 (1969).

    CAS  Google Scholar 

  • Levine, H. J., Bergenstal, D. M., Thomas, L. B.: Persistent lactation: Endocrine and histologic studies in 5 cases. Amer. J. med. Sci. 243, 118–128 (1962).

    Article  Google Scholar 

  • Lewis, A. A., Gomez, E. T., Turner, C. W.: Mammary gland development with mammogen in the castrate and the hypophysectomized rat. Endocrinology 30, 37–47 (1942).

    Article  Google Scholar 

  • Lewis, A. A., Turner, C. W.: Effect of stilbestrol on the mammary gland of the mouse, rat, rabbit and goat. J. Dairy Sci. 24, 845–860 (1941).

    Article  CAS  Google Scholar 

  • Lewis, A. A., Turner, C. W.: (a) Growth of the male guinea pig mammary gland with diethylstilbestrol. Endocrinology 30, 585–590 (1942).

    Article  CAS  Google Scholar 

  • Lewis, A. A., Turner, C. W.: (b) Mammogen and unilateral mammary growth in the rabbit. Endocrinology 30, 985–989 (1942).

    CAS  Google Scholar 

  • Lieser, H.: Beiträge zur Histologie und Feinstruktur der Mamma unter dem Ein- fluĂź von Geschlechtshormonen. Diss. Mainz 1964.

    Google Scholar 

  • Linzell, J. L.: The silver staining of myoepithelial cells, particulary in the mammary gland, and their relation of the ejection of milk. J. Anat. (Lond.) 86, 49–57 (1952).

    CAS  Google Scholar 

  • Linzell, J. L.: Some observations on the contractile tissue of the mammary glands. J. Physiol. (Lond.) 130, 257–267 (1955).

    CAS  Google Scholar 

  • Litten, L.: Die histologischen Grundlagen der Sekretion nicht-gravider Mammae. Virchows Arch. path. Anat. 259, 126–146 (1926).

    Google Scholar 

  • Litwer, G.: Die histologischen Veränderungen der Kropfwanderung bei Tauben zur Zeit der BebrĂĽtung und AusfĂĽtterung ihrer Jungen. Z. Zellforsch. 3, 695–722 (1926).

    Article  Google Scholar 

  • Luchsinger, Y., Centeno, J.: Ăśber die zyklischen Veränderungen der weiblichen BrustdrĂĽse. Beitr. path. Anat. 78, 594–617 (1927).

    Google Scholar 

  • Lustig, H.: Zur Entwicklungsgeschichte der menschlichen BrustdrĂĽse. Arch. mikr. Anat. 87, 38–59 (1915).

    Article  Google Scholar 

  • Lyons, W. R.: The hormonal basis for “witches milk”. Proc. Soc. exp. Biol. (N. Y.) 37, 207–209 (1938).

    Article  Google Scholar 

  • Lyons, W. R.: The direct mammotrophic action of lactogenic hormone. Proc. Soc. exper. Biol. (N. Y.) 51, 308–311 (1942).

    Article  CAS  Google Scholar 

  • Lyons, W. R.: Lobulo-alveolar mammary growth in the rat. Colloq. int. Cent. nat. Rech. sci. No. 32, 29–38 (1951).

    Google Scholar 

  • Lyons, W. R., Catchpole, H. R.: (a) “Assay with the guinea pig of the lactogenic hypophyseal hormone”. Proc. Soc. exp. Biol. (N. Y.) 31, 299–301 (1933).

    Article  Google Scholar 

  • Lyons, W. R., Catchpole, H. R.: (b) “Availability of the rabbit for assay of the hypophyseal lactogenic hormone”. Proc. Soc. exp. Biol. (N. Y.) 31, 305–309 (1933).

    Article  Google Scholar 

  • Lyons, W. R., Johnson, R. E., Cole, R. D., Li, C. H.: Mammary growth and lactation in male rats. In: The hypophyseal growth hormone, nature and actions (eds. R. W. Smith, O. A. Gaebler and C. N. H. Long), p. 461–472. New York: The Blakiston Division 1955.

    Google Scholar 

  • Lyons, W. R., Li, C. H., Johnson, R. E.: Localaction of pituitary and ovarian hormones on the mammary glands of hypophysectomized-oophorectomized rats. Anat. Rec. 127, 432–433 (1957).

    Google Scholar 

  • Lyons, W. R., Li, C. H., Johnson, R. E.: The hormonal control of mammary growth an lactation. Recent Progr. Hormone Res. 14, 219–254 (1958).

    CAS  Google Scholar 

  • Lyons, W. R., McGinty, D. A.: Effects of estrone and progesterone on male rabbit mammary gland. I. Varying doses of progesterone. Proc. Soc. exper. Biol. (N. Y.) 48, 83–86 (1941).

    Article  CAS  Google Scholar 

  • Maeder, L. M. A.: Changes in the mammary gland of the albino rat (Mus norvegicus albus) during lactation and involution. Amer. J. Anat. 31, 1–26 (1922/23).

    Article  Google Scholar 

  • Mahesh, V. B., Dalla Pria, S., Greenblatt, R. B.: Abnormal lactation with Cushing’s syndrom-a case report. J. clin. Endocr. 29, 978–981 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Masshoff, W.: Die physiologische Regeneration. In: Handbuch der allgemeinen Pathologie, Bd. VI/1, S. 489, von F. BĂĽchner, E. Letterer und F. Roulet. Berlin-Göttingen-Heidelberg: Springer 1955.

    Google Scholar 

  • Mayer, G., Klein, M.: Histology and cytology of the mammary gland. In: Milk: The mammary gland and its secretion, ed. by S. K. Kon and A. T. Cowie, vol. I, p. 47–126. New York and London: Academic Press 1961.

    Google Scholar 

  • McCullagh, E., Alivisatos, J. G., Schaffenburg, C. A.: Pituitary tumor with gynecomastia and lactation. J. clin. Endocr. 16, 397–405 (1956).

    Article  PubMed  CAS  Google Scholar 

  • McDonald, G. J., Reece, R. P.: Quantitative response of rat mammary glands to mammogens. I. Estrogen alone with progesterone. Proc. Soc. exp. Biol. (N. Y.) 110, 647–649 (1962).

    Article  Google Scholar 

  • McEuen, C.S.: Some effects of prolonged administration of oestrin in rats. Lancet 1936 I, 775–776.

    Article  CAS  Google Scholar 

  • McEuen, C.S.: Role of pituitary in effect of testosterone on the mammary gland. Proc. Soc. exp. Biol. (N. Y.) 36, 213–215 (1937).

    Article  CAS  Google Scholar 

  • McEuen, C.S.: Selye, H., Collip, J. B.: Effect of the testis on the mammary gland. Proc. Soc. exp. Biol. (N. Y.) 35, 56–58 (1936).

    Article  Google Scholar 

  • Meier-Ruge, W.: Die diagnostische Bedeutung des Sexchromatingehaltes in Relation von Enzymhistochemie, DNS-Gehalt und Mitoseindex beim Mamma-carcinom. Verh. dtsch. Ges. Path. 50, 330–335 (1966).

    CAS  Google Scholar 

  • Meites, J.: (a) Mammary growth and lactation. In: Reproduction in domestic animals, ed. by H.H. Cole and P.T. Cupps, vol.1, p. 539–593. New York and London: Academic Press 1959.

    Google Scholar 

  • Meites, J.: (b) Induction and maintenance of mammary growth and lactation in rats with acetylcholin or epinephrine. Proc. Soc. exp. Biol. (N. Y.) 100, 750–754 (1959).

    Article  CAS  Google Scholar 

  • Meites, J.: Farm animals: hormonal induction of lactation and galactopoesis. In: Milk: The mammary gland and its Secretion, ed. by S. K. Kon and A. T. Cowie. New York: Academic Press 1961.

    Google Scholar 

  • Meites, J.: Maintenance of the mammary lobuloalveolar system in rats after adrenoorchid-ectomy by prolactin and growth hormone. Endocrinology 76, 1220–1223 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Meites, J.: Effects of altering the balance between prolactin and ovarian hormones on initiation of lactation in rabbits. Endocrinology 55, 530–534 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Meites, J., Sgouris, J. T.: Can the ovarian hormones inhibit the mammary response to the prolactin? Endocrinology 53, 17–23 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Meites, J., Turner, C. W.: The induction of lactation during pregnancy in rabbits on the specifity of the lactogenic hormone. Amer. J. Physiol. 150, 394–399 (1947).

    PubMed  CAS  Google Scholar 

  • Merz, W.: BrustdrĂĽsenschwellung bei Neugeborenen. Schweiz, med. Wschr. 11, 213–217 (1946).

    Google Scholar 

  • Meyer, H.: Experimentelle Pathomorphogenese der Mamma unter dem EinfluĂź männlicher Geschlechtshormone. Inaug.-Diss. Mainz, 1967.

    Google Scholar 

  • Mixner, J. P.: Influence of environmental temperature on growth of mammary lobule-alveolar system. Proc. Soc. exp. Biol. (N. Y.) 48, 443–445 (1941).

    Article  CAS  Google Scholar 

  • Mixner, J. P.: (a) Role of estrogen in the stimulation of mammary lobule-alveolar growth by progesterone and by the mammogenic lobule-alveolar growth factor of the anterior pituitary. Endocrinology 30, 591–597 (1942).

    Article  CAS  Google Scholar 

  • Mixner, J. P.: (b) Progesterone like-activity of some steroid compounds and of diethylstilbestrol in stimulating mammary lobule-alveolar growth. Endocrinology 30, 706–710 (1942).

    Article  CAS  Google Scholar 

  • Mixner, J. P.: (c) Influence of thyroxine upon mammary lobule-alveolar growth. Endocrinology 31, 345–348 (1942).

    Article  CAS  Google Scholar 

  • Mixner, J. P.: The mammogenic hormones of the anterior pituitary. II. The lobulo-alveolar growth factor. Res. Bull. Mo. agric. Exp. Sta. 378 (1943).

    Google Scholar 

  • Mixner, J. P.: Strain differences in response of mice to mammary gland stimulating hormones. Proc. Soc. exp. Biol. (N. Y.) 95, 87–89 (1957).

    Article  CAS  Google Scholar 

  • Mixner, J. P., Turner, C. W.: Growth of the lobule-alveolar system of the mammary gland with pregneninolone. Proc. Soc. exp. Biol. (N. Y.) 47, 453–456 (1941).

    Article  CAS  Google Scholar 

  • Möbius, G., Nizze, H.: Mastopathia fibrosa cystica und Epithelproliferationen in der weiblichen BrustdrĂĽse des Sektionsgutes. Frankfurt. Z. Path. 75, 297–305 (1966).

    PubMed  Google Scholar 

  • Moon, R. C.: Mammary gland cell content during various phases of lactating. Amer. J. Physiol. 203, 939–941 (1962).

    CAS  Google Scholar 

  • Moon, R. C.: Influence of graded thyroxin levels on mammary gland growth. Amer. J. Physiol. 203, 942–946 (1962).

    CAS  Google Scholar 

  • Moon, R. C., Griffith, D. R., Turner, C. W.: Normal and experimental growth of rat mammary gland. Proc. Soc. exp. Biol. (N. Y.) 101, 788–790 (1959).

    Article  CAS  Google Scholar 

  • Moon, R. C., Turner, C. W.: Thyroid hormone and mammary growth in the rat. Proc. Soc. exp. Biol. (N. Y.) 103, 149–151 (1960).

    Article  CAS  Google Scholar 

  • Mosimann, W.: Vergrößerung der Kernvolumina in der Parathyreoidea und vermehrte Kalziumausscheidung in der Milch bei Ziegen nach kĂĽnstlicher Auslösung der Laktation durch Oestrogen. Schweiz. Arch. Tierheilk. 97, 178–187 (1955).

    CAS  Google Scholar 

  • Mosimann, W.: Das Volumen der Zellkerne im Epithel der MilchdrĂĽse in Abhängigkeit vom Funktionszustand und bei Stilboestrol-Zufuhr. Z. mikr.-anat. Forsch. 63, 303–316 (1957).

    PubMed  CAS  Google Scholar 

  • MĂĽhlbrock, O.: The oestrone-sensitivity of the mammary gland in female mice of various strains. Acta brev. neerl. physiol. 16, 22–27 (1948).

    Google Scholar 

  • MĂĽllerheim, R.: Ovarialtumoren bei Greisinnen mit Hypertrophie der Mammae und des Uterus und mit uterinen Blutungen. Zbl. Gynäk. 52, 689 (1928).

    Google Scholar 

  • Munford, R. E.: The effect of Cortisol acetate on oestrone-induced mammary growth in immature ovariectomized albino mice. J. Endocr. 16, 72–79 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Munford, R. E.: A reviev of anatomical and biochemical changes in the mammary gland with particular reference to quantitative methods of assessing mammary development. Dairy Sci., Abstr. 26, 293–304 (1964).

    Google Scholar 

  • Munger, B. L.: The ultrastructure and histophysiology of human eccrine sweat glands. J. biophys. biochem. Cytol. 11, 385–402 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Munson, P. L.: Studies on the role of the parathyreoids in calcium and phosphorus metabolism. Ann. N. Y. Acad. Sci. 60, 776–795 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Murad, T. M., Haam, E. v.:Ultrastructure of myoepithelial cells in human mammary gland tumors. Cancer (Philad.) 21, 1137–1149 (1968).

    Article  CAS  Google Scholar 

  • Mylius, E. A.: The identification and the role of the myoepithelial cell in salivary gland tumors. Acta path, microbiol. scand., Suppl. 139, 50 (1960).

    Google Scholar 

  • Nandi, S.: (a) Role of somatotropin in mammogenesis and lactogenesis in C3H/He CRGL mice. Science 128, 772–774 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Nandi, S.: (b) Endocrine control of mammary gland development and function in the C3H/He CRGL mouse. J. nat. Cancer Inst. 21, 1939–1963 (1958).

    Google Scholar 

  • Nandi, S.: (c) Hormonal control of mammogenesis and lactogenesis in the C3H-He crgl. mouse. Univ. Calif. Publ. Zool. 65, 1–128 (1959).

    Google Scholar 

  • Needham, D. M., Shoenberg, C. F.: Proteins of the contractile mechanismen of mammalian an smooth muscle and their possible location in the cell. Proc. roy. Soc., Ser. B (London) 160, 517–522 (1964).

    Article  CAS  Google Scholar 

  • Neimeier, R., Hauser, G. A., Keller, M., Labhardt, F., Wenner, R., Stampfli, V.: Die pathologische Lactation. Schweiz, med. Wschr. 89, 442–445 (1959).

    CAS  Google Scholar 

  • Nelson, W.O.: Endocrine control of the mammary gland. Physiol. Rev. 16, 488—526 (1936).

    Google Scholar 

  • Nelson, W.O.: Studies on the physiology of lactation. VI. The endocrine influences concerned in the development and function of the mammary gland in the guinea pig. Amer. J. Anat. 60, 341–365 (1937).

    Article  CAS  Google Scholar 

  • Nelson, W. O.: (a) Growth of mammary gland following local application of estrogenic hormone. Amer. J. Physiol. 133, 397–398 (1941).

    Google Scholar 

  • Nelson, W.O.: (b) Production of sex hormones in the adrenals. Anat. Rec., Suppl. 1, 81, 97 (1941).

    Google Scholar 

  • Nelson, W. O., Heytler, P. G., Ciacco, E. I.: Guinea pig mammary gland growth changes in weight, nitrogen and nucleic acids. Proc. Soc. exp. Biol. (N. Y.) 109, 373–375 (1962).

    Article  CAS  Google Scholar 

  • Nelson, W. O., Merckel, C. G.: Effects of androgenic substances in the female rat. Proc. Soc. exp. Biol. (N. Y.) 36, 823–825 (1937).

    Article  Google Scholar 

  • Neumann, F., Elger, W.: The effect of the anti-androgen 1,2 α-methylene-6-chloro- Δ 4,6 pregnandiene-17 α-ol-3,20-dione-17 α-acetate (cyproterone-acetate) on the development of the mammary glands of male foetal rats. J. Endocr. 36, 347–352 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Neumann, F., Elger, W.: Steroid stimulation of mammary glands in prenatally feminized male rats. Europ. J. Pharmacol. 1, 120–123 (1967).

    Article  CAS  Google Scholar 

  • Neumann, F., Elger, W.: Berswordt-Wallrabe, R. von: The structure of the mammary glands and lactogenesis in feminized male rats. J. Endocr. (Lond.) 36, 353–356 (1966).

    Article  CAS  Google Scholar 

  • Neumann, H. O., Oing, M.: Polymastie und Polythelie. Eine klinische Studie mit einem entwicklungsgeschichtlich-historischen Beitrag. Arch. Gynäk. 13, 494–542 (1929).

    Article  Google Scholar 

  • Newman, W.: In situ lobular carcinoma of the breast. Report of 26 woman with 32 cases. Ann. Surg. 157, 591–599 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Newman, W.: Lobular carcinoma of the female breast. Report of 73 cases. Ann. Surg. 164, 305–314 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Nicoll, C. S.: Growth autoregulation and the mammary gland. J. nat. Cancer Inst. 34, 131–140 (1965).

    PubMed  CAS  Google Scholar 

  • Nicoll, C. S., Meites, J.: Prolactin secretion in vitro: effects of thyreoid hormones and insulin. Endocrinology 72, 544–551 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Noble, R. L., McEuen, C. S., Collip, J. B.: Mammary tumors produced in rats by the action of estrone tablets. Canad. med. Ass. J. 42, 412–417 (1940).

    Google Scholar 

  • Nordmann, M.: Fibrosis mammae virilis. Klin. Wschr. 26, 220–221 (1948).

    Article  PubMed  CAS  Google Scholar 

  • Norgren, A.: Effects of different doses of oestrogen and progesterone on mammary glands of gonadectomized rabbits. Acta Univ. Lund. Sectio II, No. 31 (1966).

    Google Scholar 

  • Nyirjesy, I.: Galactorrhoea without amenorrhoea. J. Obstet, Gynec. 32, 52–57 (1968).

    CAS  Google Scholar 

  • Oestereich, R., Slawyk: Riesenwuchs und ZirbeldrĂĽsen-Geschwulst. Virchows Arch. path. Anat. 157, 475–484 (1899).

    Google Scholar 

  • Olivi, M., Barbieri, G.: La mastopathia fibrocistica. Lav. Ist. Anat. Univ. Perugia 12, 311–323 (1952).

    Google Scholar 

  • Overzier, C.: Gynäkomastie bei paradoxer Fettsucht — ein Beitrag zum Gynäko- mastieproblem. Ă„rztl. Wschr. 4, 4–10 (1949).

    Google Scholar 

  • Ozzello, L., Speer, F.D.: The mucopolysaccharides in the normal and diseased breast. Their distribution and significance. Amer. J. Path. 34, 993–1009 (1958).

    PubMed  CAS  Google Scholar 

  • Paek, S.: Histochemisches Enzymmuster der Mamma unter dem experimentellen EinfluĂź von Geschlechtshormonen. Inaug.-Diss. Mainz, 1967.

    Google Scholar 

  • Perrini, F.: Action of stilboestrol and progesterone on the mammary gland. G. Ostet. Ginec. 17, 59–74 (1953)

    Google Scholar 

  • Philipp, E.: Schwangerschaftsveränderungen beim Neugeborenen. Klin. Wschr. 17, 797–800 (1938).

    Article  Google Scholar 

  • Price, D., Williams-Ashman, H. G.: The accessory reproductive glands of mammals. In: Sex and internalse cretions, 3d, ed. by Young, W. C., p. 366–448. Williams & Wilkins 1961.

    Google Scholar 

  • Rapoport, S. M.: Medizinische Biochemie, Berlin 1962.

    Google Scholar 

  • Ratzenhofer, M.: Zum Verhalten des Mesenchyms bei chronischer Mastopathie und Mammacarcinom. Wien. med. Wschr. 101, 681–686 (1951).

    Google Scholar 

  • Ratzenhofer, M., Schauenstein, E.: (a) Weitere biophysikalische Untersuchungen des Gewebs-saftes bei Mammacarcinom. Z. Krebsforsch. 58, 707–710 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Ratzenhofer, M., Schauenstein, E.: (b) Ăśber den Nachweis von Albuminen im Gewebssaft bei krebsig entarteter Mastopathie. Z. Krebsforsch. 58, 198–200 (1952).

    Article  CAS  Google Scholar 

  • Ray, E. W., Averill, S. C., Lyons, W. R., Johnson, R. E.: Rat placental hormone activities corresponding to those of pituitary mammotropin. Endocrinology 56, 359–373 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Raynaud, A.: (a) Effet des injections d’hormones sexuelles Ă  la souris gravide, sur le dĂ©veloppement des Ă©bauches de la glande mammaire des embryous. I. A.tion des substances androgenes. Ann. Endocr. (Paris) 8, 248–253 (1947).

    CAS  Google Scholar 

  • Raynaud, A.: (b) Action de fortes doses des substances oestrogènes. Ann. Endocr. (Paris) 8, 318–329 (1947).

    CAS  Google Scholar 

  • Raynaud, A.: (c) Inhibition du dĂ©veloppement des Ă©bauches mammaires de l’embryon de souris sous l’effet d’une hormone oestrogène injectĂ©e directement á l’embryon. C. R. Soc. Biol. (Paris) 146, 544–549 (1952).

    CAS  Google Scholar 

  • Raynaud, A.: (d) Morphogenesis of the mammary gland. In: Milk: The mammary gland and its secretion, ed. by S. K. Kon, and A. T. Cowie, vol. I, p. 1–46. New York and London: Academic Press 1961.

    Google Scholar 

  • Raynaud, A.: (f) Le dĂ©veloppement embryonnaire de la glande mammaire de la souris après destruction au moyen des rayons X des glandes gĂ©nitales de l’embryon. Bull. Soc. zool. France, 74, 156–159 (1949).

    Google Scholar 

  • Raynaud, A.: (h) La production expĂ©rimental de malformations mammaires chez les foetus de souris par l’action des hormones sexuelles. A.n. Inst. Pasteur 90, 39–219 (1956).

    CAS  Google Scholar 

  • Raynaud, A.: Frilley, M.: (e) Etat de dĂ©veloppement des Ă©bauches mammaires et du cordon vaginal chez le foetus mâles et femelles de souris, dout les Ă©bauches des glandes gĂ©nitales ont Ă©tĂ© dĂ©truites par une irradiation au moyen des rayon X, a l’âge de treize jours. C. R. Acad. Sci. (Paris) 225, 1380–1382 (1947).

    Google Scholar 

  • Raynaud, A., Raynaud, J.: (g) Les diverses malformations mammaires produites chez les foetus de souris, par l’action des hormonelles sexuelles. C. R. Soc. Biol. (Paris) 148, 963–968 (1954).

    CAS  Google Scholar 

  • Reece, R. P., Mixner, J. P.: Effect of testosterone on pituitary and mammary gland. Proc. Soc. exp. Biol. (N. Y.) 40, 66–67 (1939).

    Article  CAS  Google Scholar 

  • Reece, R. P., Leathem, J. H.: Growth of mammary glands of hypophysectomized rats following estrogen and lactogen administration. Proc. Soc. exp. Biol. (N. Y.) 59, 122–124 (1945).

    Article  CAS  Google Scholar 

  • Reece, R. P., Leonard, S. L.: Lobule-alveolar growth of mammary glands of hypophysectomized female rats. Proc. Soc. exp. Biol. (N. Y.) 49, 660–662 (1942).

    Article  CAS  Google Scholar 

  • Rein, G.: Untersuchungen ĂĽber die embryonale Entwicklungsgeschichte der MilchdrĂĽse. Arch. mikr. Anat. 20, 431–501 (1882); 21, 678–694 (1882).

    Article  Google Scholar 

  • Reinecke, E. P., Meites, J., Cairy, C. F., Huffman, D. F.: Hormonal induction for lactation in sterile cows. In: Proceedings annual meeting American Veterinary Medical Association, 1952, p. 325–328, Atlantic City. Amer. Veterinary Med. Ass.

    Google Scholar 

  • Richardson, K. C.: (a) Some structural features of the mammary tissues. Brit, med. Bull. 5, 123–129 (1947).

    CAS  Google Scholar 

  • Richardson, K. C.: (b) Contractile tissues in the mammary gland with special reference to myoepithelium in the goat. Proc. roy. Soc. B 136, 30–45 (1949).

    Article  CAS  Google Scholar 

  • Richardson, K. C.: (c) Measurement of the total area of secretory epithelium with lactatin mammary gland of the goat. J. Endocr. 9, 170–184 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Richardson, K. C.: (d) Mammary tumors and mammary gland development in normal and oestrogen-treated F 1 hybrids of strains C3 H/J and R Ill/An mice. J. nat. Cancer Inst. 36, 1167–1187 (1966).

    PubMed  CAS  Google Scholar 

  • Richardson, K. C.: (e) The acinar pattern in the mammary glandes of virgin mice at different ages. J. nat. Cancer Inst. 38, 305–315 (1967).

    PubMed  CAS  Google Scholar 

  • Riddle, O.: Prolactin invertebrate function and organization. J. nat. Cancer Inst. 31, 1039–1110 (1963).

    PubMed  CAS  Google Scholar 

  • Riddle, O.: The preparation, identification and assay of prolactin — a hormone of the anterior pituitary. Amer. J. Physiol. 105, 191–216 (1933).

    CAS  Google Scholar 

  • Riddle, O., Bates, R. W., Dykshorn, S. W.: A new hormone of the anterior pituitary. Proc. Soc. exp. Biol. (N. Y.) 29, 1211–1212 (1932).

    Article  Google Scholar 

  • Riddle, O., Braucher, P. F.: Studies on the physiology of reproduction in birds. XXX. Control of the special secretion of the crop-gland in pigeons by an anterior pituitary hormone. Amer. J. Physiol. 97, 617–625 (1931).

    CAS  Google Scholar 

  • Riedel, G.: Die Entwicklung und Entartung des elastischen Gewebes in der senilen Mamma. Virchows Arch. path. Anat. 256, 242–267 (1925).

    Google Scholar 

  • Rosen, S.W., Gahres, E. E.: Nonpuerperal galactorrhoea and the contraceptive pill. J. Obstet. Gynec. 29, 730–731 (1967).

    CAS  Google Scholar 

  • Rosenburg, A.: Ăśber menstruelle, durch das Corpus luteum bedingte Mamma-veränderungen. Frankfurt. Z. Path. 27, 466–506 (1922).

    Google Scholar 

  • Ross, R., Klebanoff, S.: Fine structural changes in uterine smooth muscle and fibroblasts in response to estrogen. J. Cell Biol. 32, 155–167 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Saameli, K.: Untersuchungen ĂĽber den Blutspiegel und die Abbaugeschwindigkeit von Oxytocin. Gynaecologia (Basel) 152, 329–332 (1961).

    CAS  Google Scholar 

  • Salter, J., Best, C. H.: Insulin as a growth hormĂłn. Brit. med. J. 1953 II, 353–359.

    Article  Google Scholar 

  • Sandritter, W., Federlin, K., Pfeiffer, E. F.: Quantitativehistochemicalstudies on islet cells. In: The structure and metabolismen of the pancreatic islets. Proc. 3rd. Internat. Symp. Stockholm, 1963. Oxford-London-Edinburgh-New York-Paris-Frankfurt: Pergamon Press 1964.

    Google Scholar 

  • Schachner, S. H.: Galactorrhoea subsequent to contraceptive hormones. New Engl. Med. J. 275, 1138–1141 (1966).

    Google Scholar 

  • Schäfer, A., Bässler, R.: Vergleichende elektronenoptische Untersuchungen am DrĂĽsenepithel und am sog. lobulären Carcinom der Mamma. Virchows Arch. Abt. A Path. Anat. 346, 269–286 (1969).

    Article  Google Scholar 

  • Schaefer, H. E., Fischer, R.: Ă–strogenbedingte Induktion alkalischer Phosphatase in Fibroblasten des subkutanen Bindegewebes der Maus. Acta endocr. (Kbh.) 57, 261–273 (1968).

    CAS  Google Scholar 

  • Schairer, E.: Kernmessungen und Chromosomenzählungen an menschlichen GeschwĂĽlsten. Z. Krebsforsch. 43, 1–38 (1936).

    Google Scholar 

  • Schaltenbrand, G.: Die Nervenkrankheiten. Stuttgart: Thieme 1951.

    Google Scholar 

  • Scharf, G., Lyons, W. R.: Effects of estrone and progesterone on male rabbit mammary glands. II. Varying doses of estrone. Proc. Soc. exp. Biol. (N. Y.) 48, 86–89 (1941).

    Article  CAS  Google Scholar 

  • Schimmelbusch, C.: Das Cystadenom der Mamma. Arch. klin. Chir. 44, 117–134 (1892).

    Google Scholar 

  • Schipp, R.: Der Feinbau filamentärer Strukturen im Endothel peripherer Lymphgefäße. Acta anat. (Basel) 71, 341–351 (1968).

    Article  CAS  Google Scholar 

  • Schmidt, Hugo: Ăśber normale Hyperthelie menschlicher Embryonen und ĂĽber die erste Anlage der menschlichen MilchdrĂĽsen ĂĽberhaupt. Schwalbes morphol. Arb. 7, 157–199 (1897).

    Google Scholar 

  • Schmitt, Heinrich: Ăśber die Entwicklung der MilchdrĂĽse und die Hyperthelie menschlicher Embryonen. Schwalbes morphol. Arb. 8, 236–303 (1898).

    Google Scholar 

  • Schnurbusch, F.: Untersuchungen ĂĽber die Morphologie der männlichen BrustdrĂĽse während des Lebensablaufes als Grundlage fĂĽr ein Studium der Gynäko-mastie. Frankfurt. Z. Path. 62, 402–418 (1951).

    PubMed  CAS  Google Scholar 

  • Schriever, D.: Histochemische Untersuchungen am Bindegewebe der Mamma in physiologischen Funktionsphasen. Inaug.-Diss. Mainz, 1968.

    Google Scholar 

  • Schultz, A.: Pathologische Anatomie der BrustdrĂĽse. In: Handbuch der speziellen pathologischen Anatomie und Histologie von O. Lubarsch und F. Henke, Weibliche Geschlechtsorgane, 7. Bd., 2. Teil. Berlin: Springer 1933.

    Google Scholar 

  • Schulze, G.: Histochemische Untersuchungen am Bindegewebe der hormonal stimulierten Mamma. Inaug.-Diss. Mainz, 1968.

    Google Scholar 

  • Segal, S. J., Scher, W.: Estrogenes, nuclei acids and protein synthesis in uterine metabolism. In: R. M. Wynn, Cellular biology of the uterus, p. 114–150. Amsterdam: North Holland publ. 1967.

    Google Scholar 

  • Seifert, G.: Ăśber Gewebsreaktionen der menschlichen BrustdrĂĽse bei Leukämien. Virchows Arch. path. Anat. 322, 336–357 (1952).

    CAS  Google Scholar 

  • Selye, H.: On the nervous control of lactation. Amer. J. Physiol. 107, 535–538 (1934).

    Google Scholar 

  • Selye, H.: Activity of progesterone in spayed female not pretreated with estrin. Proc. Soc. exp. Biol. (N. Y.) 43, 343–344 (1940).

    Article  CAS  Google Scholar 

  • Selye, H.: (a) Stress and lactation. Rev. canad. Biol. 13, 377–384 (1954).

    PubMed  CAS  Google Scholar 

  • Selye, H.: (b) The effect of Cortisol upon the mammary glands. Acta endocr. (Kbh.) 17, 394–401 (1954).

    CAS  Google Scholar 

  • Selye, H., Browne, J. S. L., Collip, J. B.: The effect of large doses of progesterone in the female rat. Proc. Soc. exp. Biol. (N. Y.) 34, 472–474 (1936).

    Article  CAS  Google Scholar 

  • Selye, H., McEuen, C. S., Collip, J. B.: Effect of testosterone on mammary gland. Proc. Soc. exp. Biol. (N. Y.) 34, 201–203 (1936).

    Article  CAS  Google Scholar 

  • Semb, C.: Fibroadenomatosis cystica mammae. Acta chir. scand. 64, Suppl. X, 1–483 (1928).

    Google Scholar 

  • Short, R. H. D.: Alveolar epithelium in relation to growth of the lung. Phil. Trans. B 235, 35–86 (1951).

    Google Scholar 

  • Silver, I. A.: Myoepithelial cells in the mammary and parotid glands. J. Physiol. (Lond.) 125, 8–9 (1954).

    CAS  Google Scholar 

  • Smith, Th. C.: The action of relaxin on mammary gland growth in the rat. Endocrinology 54, 59–70 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Smith, Th. C.: The effect of estrogen and progesterone on mammary gland growth in the rat. Endocrinology 57, 33–43 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Smith, Th. C.: Action of estrogen and progesterone on mammary nucleic acids and enzymes in rats. Endocrinology 65, 51–55 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Smith, Th. C.: Braverman, L. B.: The action of desoxycorticosterone acetate on the mammary gland of the immature ovariectomized rat. Endocrinology 52, 311–317 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Smith, Th C., Richterich, B.: Synergism of estrogen and progesterone on mammary growth in guinea pigs. Endocrinology 63, 89–98 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Smithcors, J. F., Leonard, S. L.: Limited effects of certain steroid hormones on mammary glands of hypophysectomized rats. Proc. Soc. exp. Biol. (N. Y.) 54, 109–111 (1943).

    Article  CAS  Google Scholar 

  • Soemarwoto, J. N., Bern, H. A.: The effect of hormones on the vascular pattern of the mouse mammary gland. Amer. J. Anat. 103, 403–435 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Speert, H.: The normal and experimental development of the mammary gland of the rhesus monkey with some pathological correlations. Contr. Embryol. Carneg. Inst. 32, 9–65 (1948).

    Google Scholar 

  • Spellacy, W. N., Carlson, K. L., Schade, S. L.: Human growth hormone studies in patients with galactorrhea (Ahumada-del-Castillo-Syndrome). Amer. J. Obstet. Gynec. 100, 84–89 (1968).

    PubMed  CAS  Google Scholar 

  • Spuler, A.: AbriĂź der Entwicklungsgeschichte der MilchdrĂĽse. In: Handbuch der Gynäkologie, hrsg. von W. Stoeckel, Bd. 1, S. 490–510. Berlin: Bergmann 1930.

    Google Scholar 

  • Stein, O., Stein, Y.: Formation of milk glycerides in lactating mice studied by electronmicroscopic autoradiography. Israel J. med. Sci. 2, 773–778 (1966).

    CAS  Google Scholar 

  • Steinbeck, H.: Die Wirkung der verschiedenen Gestagene auf Morphologie und Funktion der MilchdrĂĽse. In: Handbuch der experimentellen Pharmakologie, hrsg. von O. Eichler, A. Farah, H. Herken und A. D. Welch, Bd. 22/2, S. 341–425. Berlin-Heidelberg-New York: Springer 1969.

    Google Scholar 

  • Stöcker, E.: (a) Autoradiographische Untersuchungen zur Deutung der funktionellen Kernschwellung am exokrinen Pankreas. Z. Zellforsch. 57, 47–62 (1962).

    Article  Google Scholar 

  • Stöcker, E.: (b) Autoradiographische Untersuchungen mit 12 H3 und 5 C14 markierten Aminosäuren zur Größe des nukleolären und zytoplasmatischen EiweiĂźstoffwechsels bei verschiedenen Zellarten von Maus und Ratte. Z. Zellforsch. 70, 419–448 (1966).

    Article  Google Scholar 

  • Stricker, P.: Recherches expĂ©rimentales sur les fonctions du lobe antĂ©rieur de l’hypophyse: influence des extraits du lobe antĂ©rieur sur l’appareil gĂ©nital de la lapine et sur la montĂ©e laiteuse. Presse mĂ©d. 37, 1268–1271 (1929).

    CAS  Google Scholar 

  • Stricker, P., Grueter, F.: Action du lobe antĂ©rieur de hypophyse sur la montĂ©e laiteuse. C.R. Soc. Biol. (Paris) 99, 1978–1980 (1928).

    Google Scholar 

  • Suchenwirth, R., Bues, F.: Galaktorrhoe als Leitsymptom bei Hypophysenadenomen. Endokrinologie 41, 66–75 (1961).

    Google Scholar 

  • Suetina, J. A., Chentsov, S., Chentsov, Y., Smirnova, J. O., Samoilov, W. J.: Action mechanism of estrogens and progesteron on the mammary glands. Arh. Patol. (Moskva) 28, 16–22 (1966).

    CAS  Google Scholar 

  • Sykes, J. F.: Hormonal development of mammary tissue in dairy heifers. J. Dairy Sci. 34, 1174–1179 (1951).

    Article  CAS  Google Scholar 

  • Sykes, J. F., Wrenn, T. R.: Hormonal development of the mammary gland of dairy heifers. J. Dairy Sci. 33, 194–204 (1950).

    Article  Google Scholar 

  • Sylven, B.: Ăśber die Elektivität und Fehlerquellen der Schleimfärbung mit Muci-carmin im Vergleich mit metachromatischer Färbung. Virchows Arch. path. Anat. 303, 280–394 (1938).

    CAS  Google Scholar 

  • Takahashi, N.: Electron microscopic studies on the ectodermal secretory glands in man. The fine structure of the apocrine sweat glands with special reference to the myoepithelium. Bull. Tokyo med. dent. Univ. 4, 259–269 (1957).

    Google Scholar 

  • Takahashi, N.: Electron microscopic studies on the extodermal secretory glands in man. II. The fine structures of the myoepithelium in the human mammary and salivary glands. Bull. Tokyo med. dent. Univ. 5, 177–192 (1958).

    Google Scholar 

  • Talwalker, P. K.: Mammary lobulo-alveolar growth in adreno-ovariectomized rats following transplantation of “mammotropic” pituitary tumor. Proc. Soc. exp. Biol. (N. Y.) 117, 121–124 (1964).

    Article  CAS  Google Scholar 

  • Talwalker, P. K., Meites, J.: Mammary lobulo-alveolar growth induced by anterior pituitary hormones in adreno-ovariectomized and adreno-ovariectomized-hypophysecto-mized rats. Proc. Soc. exp. Biol. (N. Y.) 107, 880–883 (1961).

    Article  CAS  Google Scholar 

  • Talwalker, P. K., Nicoll, C.S., Meites, J.: Induction of mammary secretion in pregnant rats and rabbits by hydrocortisone acetate. Endocrinology, 69, 802–808 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Tamarin, A.: Myoepithelium of rat submaxillary gland. J. Ultrastruct. Res. 16, 320–338 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Tandler, B.: Ultrastructure of the human submaxillary gland. Z. Zeilforsch. 68, 852–863 (1965).

    Article  Google Scholar 

  • Taylor, H. C.: (a) The relation of chronic mastitis to certain hormones of the ovary and pituitary and to coincident gynecological lesions. Surg. Gynec. Ostet. 62, 129–148 (1936).

    Google Scholar 

  • Taylor, H. C.: (b) The relation of chronic mastitis to certain hormones of the ovary and pituitary and to coincident gynecological lesions. Surg. Gynec. Obstet. 62, 562–584 (1936).

    Google Scholar 

  • Taylor, H. C., Waltman, C.A.: Hyperplasias of the mammary gland in the human being and in the mouse. Arch. Surg. 40, 733–820 (1940).

    Article  CAS  Google Scholar 

  • Terzakis, I. A.: The ultrastructure of monkey eccrine sweat glands. Z. Zellforsch. 64, 493–509 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Thölen, H.: Das embryonale und postnatale Verhalten der männlichen BrustdrĂĽse beim Menschen. I. Das Mammaorgan beim Embryo und Säugling. Acta anat. (Basel) 8, 201–235 (1949).

    Article  Google Scholar 

  • Thoenes, W.: Mikromorphologie des Nephron nach temporärer Ischämie. Stuttgart: Thieme 1964.

    Google Scholar 

  • Traurig, H.: (a) Cell proliferation in the mammary gland during late pregnancy and lactation. Anat. Rec. 157, 489–504 (1967).

    Article  Google Scholar 

  • Traurig, H.: (b) A radioautographic study of all proliferation in the mammary gland of the pregnant mouse. Anat. Rec. 159, 239–248 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Trentin, J. J.: The experimental development of the mammary gland with special reference to the interaction of the pituitary and ovarian hormones. Mo. agric. Exp. Sta. Res. Bull Nr. 418 (1948).

    Google Scholar 

  • Trentin, J. J., Turner, C. W.: Effect of adrenalectomy on the mammary gland of the castrated and estrogen treated male rat. Endocrinology 41, 127–134 (1947).

    Article  PubMed  CAS  Google Scholar 

  • Treves, N.: Gynecomastia. The origins of mammary swelling in the male: an analysis of 406 patients with breast hypertrophy, 525 with testicular tumors and 13 with adrenal neoplasma. Cancer (Philad.) 11, 1082–1102 (1958).

    Google Scholar 

  • Tucker, H. A.: (b) Nuclei acid content of mammary glands of lactating rats. Proc. Soc. exp. Biol. (N. Y.) 112, 409–412 (1963).

    Article  CAS  Google Scholar 

  • Tucker, H. A.: (d) Nuclei acid of rat mammary glands during post-lactational involution. Proc. Soc. exp. Biol. (N. Y.) 112, 1002–1004 (1963).

    Article  CAS  Google Scholar 

  • Tucker, H. A., Reece, R. P.: (a) Nuclei acid content of mammary glands of pregnant rats. Proc. Soc. exp. Biol. (N. Y.) 112, 370–372 (1963).

    Article  CAS  Google Scholar 

  • Tucker, H. A., Reece, R. P.: (c) Nuclei acid content of mammary gland of rats lactating 41 and 61 days. Proc. Soc. exp. Biol. (N.Y.) 112, 688–690 (1963).

    Article  CAS  Google Scholar 

  • Turner, C. W.: The mammary gland. I. The anatomy of the udder of cattle and domestic animals. Columbia: Lucas Brothers 1952.

    Google Scholar 

  • Turner, C. W., Gomez, E. T.: The experimental development of the mammary gland. I. The male and female albino mouse. II. The male and female guinea pig. Mo. agric. Exp. Sta. Res. Bull. Nr. 206 (1934).

    Google Scholar 

  • Turner, C. W., Yamamoto, H., Ruppert, H. L.: The experimental induction of growth of the cow’s udder and the initiation of milk secretion. J. Dairy Sci. 39, 1717–1729 (1956).

    Article  CAS  Google Scholar 

  • Urban, J. A., Adair, F. E.: Sklerosing adenosis. Cancer (Philad.) 2, 625–634 (1949).

    Article  CAS  Google Scholar 

  • Verley, J. M., Hollmann, K. H.: Synthese et rĂ©absorption des proteines dans la glande mammaire en stase Ă©tude autoradiographique au microscope Ă©lectronique. Z. Zellforsch. 75, 605–610 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Verne, J.: État actuell de la cytochimie de la glande mammaire. Cell. int. Cent. nat. Rech. sci. 32, 59–66 (1951).

    Google Scholar 

  • Veronesi, U., Candiani, M. A.: La glandola mammaria muliebre nella senescenca. Biol. lat. (Milano) 8, 7–100 (1955).

    Google Scholar 

  • Vigneaud, P. G. du, Ressler, C., Swan, J. M., Roberts, C. W., Katsoyamis, P. G., Gordon, S.: The synthesis of an octapeptide amide with the hormonal activity of oxytocin. J. Amer. chem. Soc. 75, 4879–4880 (1953).

    Article  Google Scholar 

  • Vigneaud, V. du, Lawler, H. C., Popenoe, E. A.: Enzymatic clearage of glycin- amide from vasopressin and a proposed structure for this pressor-antidiuretic hormone of the posterior pituitary. J. Amer. chem. Soc. 75, 4880–4881 (1953).

    Article  Google Scholar 

  • Villani, G., Zanella, E.: II tissue elastico nei tumori e in altre forme patologiche della mammella. Arch. De Vecchi Anat. pat. 17, 537–552 (1951).

    PubMed  CAS  Google Scholar 

  • Vitry, G.: Modification histochimique de la substance fondamentale du tissu conjonctif, de la tetine du cobaye sans l’action de diverse hormones sexuelles. C.R. Soc. Biol. (Paris) 147, 124–126 (1953).

    CAS  Google Scholar 

  • Vogler, E.: Ăśber das basilare Helle-Zellen-Organ der menschlichen BrustdrĂĽse. Klin. Med. (Wien) 2, 159–167 (1947).

    CAS  Google Scholar 

  • Volkmann, H.: Zahlen und Daten zur Funktion der MilchdrĂĽsen. Zusammenstellung und Tabelle (Beilage). Med. Klin. 39 (1951).

    Google Scholar 

  • Voss, H. E.: Die hormonale Regelung der Laktation. Dtsch. med. Wschr. 83, 288–291, 328–331 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Wagenen, G. van, Folley, S. J.: Effect of androgens on mammary gland of female rhesus monkey. J. Endocr. 1, 367–372 (1939).

    Article  Google Scholar 

  • Wattenwyl, H. v.: Tierexperimentelle Untersuchungen ĂĽber die Wirkung langdauernder Follikelhormonapplikation und die hormonale Tumorentstehung. Inaug.-Diss. Basel, 1944.

    Google Scholar 

  • Watzka, M.: Zellen mit spezialen Funktionen. In: Handbuch der allgemeinen Pathologie, hrsgg. von F. BĂĽchner, E. Letterer und R. Roulet, Bd. II/1. Berlin-Göttingen-Heidelberg: Springer 1955.

    Google Scholar 

  • Waugh, D., Hoeven, E. van der: Fine structure of the human adult female breast. Lab. Invest. 11, 220–228 (1962).

    PubMed  CAS  Google Scholar 

  • Weber, A. T., Kitchell, R. L., Sautter, III.: Mammary gland studies. I. The identity and characterization of the smallert lobule unit in the udder of the dairy cow. Amer. J. vet. Res. 16, 255–263 (1955).

    PubMed  CAS  Google Scholar 

  • Weber, W.: Zur Histologie und Cytologie der Kröpfmilchbildung der Taube. Z. Zellforsch. 56, 247–276 (1962).

    Article  Google Scholar 

  • Weichert, C. K., Boyd, R. W., Cohen, R. S.: A study of certain endocrine effects in the mammary glands of female rats. Anat. Rec. 61, 21 (1934).

    Article  Google Scholar 

  • Wellings, S. R., Nandi, S.: Electron microscopy of induced secretion in mammary epithelial cells of hypophysectomized-ovarectomized-adrenalectomized BALB/c Crgl mice. J. nat. Cancer Inst. 40, 1245–1258 (1968).

    PubMed  CAS  Google Scholar 

  • Wellings, S. R., Philp, J. R.: The function of the Golgi apparatus in lactating cells of the BALB/c Crgl mouse. An electron microscopic and autoradiographic study. Z. Zellforsch. 61, 871–882 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Wenner, R.: Physiologische und pathologische Lactation. Arch. Gynäk. 204, 171–206 (1966).

    Article  Google Scholar 

  • Werner, K. H.: Ăśber die Wirkung des Follikelhormons auf die MilchdrĂĽsen kastrierter Ratten. Diss. Leipzig 1938.

    Google Scholar 

  • Wiider, J. A., Marshall, J. R., Ross, G. T.: Familial galactorrhoea in three sisters with oligo-ovulation. J. Amer. med. Ass. 209, 669–671 (1969).

    Article  Google Scholar 

  • Williams-Ashman, H. G.: Androgenic control of nucleic acid and protein synthesis in male accenory genital organs. J. cell. comp. Physiol. 66, 111–124 (1965).

    Article  CAS  Google Scholar 

  • Wyk, J. J. v., Grumbach, M. M.: Syndrom of precocious menstruation and galactorrhea in juvenil hypothyreoidism: an example of hormonal overlap in pituitary feedback. J. Pediat. 57, 416–435 (1960).

    Article  Google Scholar 

  • Yamamoto, H., Turner, C. W.: Experimental mammary gland growth in rabbits by estrogen and progesterone. Proc. Soc. exp. Biol. (N. Y.) 92, 130–132 (1956).

    Article  CAS  Google Scholar 

  • Zaks, M. G.: The motor apparatus of the mammary gland, ed. by A. T. Cowie. Edinburgh and London: Oliver and Boyd 1962.

    Google Scholar 

  • Zarzycki, L., Peryt, A., Klubinska, B., Hjac, T., Zak, K.: Histochemische Untersuchungen ĂĽber den Involutionsmechanismus der MilchdrĂĽse. Histochemie 18, 314–320 (1969).

    PubMed  CAS  Google Scholar 

  • Zondek, B., Bromberg, Y. M., Rozin, S.: An anterior pituitary hyperhormotrophic syndrome. J. Obstet. Gynaec. Brit. Emp. 58, 525–537 (1951).

    Article  PubMed  CAS  Google Scholar 

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Bässler, R. (1970). The Morphology of Hormone Induced Structural Changes in the Female Breast. In: Altmann, HW., et al. Current Topics in Pathology. Current Topics in Pathology, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-30514-0_1

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