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Secretion of Mammalian Proteins that Lack a Signal Sequence

  • Chapter
Unusual Secretory Pathways: From Bacteria to Man

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Cells are surrounded by an impermeable membrane whose integrity is essential to maintain the differences (in ionic concentration, redox potential etc.) between the cytoplasm and the extracellular space. Yet, cells avoid isolation and communicate by sending each other macromolecular messages in the form of secretory proteins. These molecules, interacting with specific receptors that span the cell membrane, activate tightly regulated systems which transduce the signal to the nucleus and elicit the appropriate responses.

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  1. Anna Rubartelli
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  2. Roberto Sitia
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Rubartelli, A., Sitia, R. (1997). Secretion of Mammalian Proteins that Lack a Signal Sequence. In: Unusual Secretory Pathways: From Bacteria to Man. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22581-3_3

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  • DOI: https://doi.org/10.1007/978-3-662-22581-3_3

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