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Properties of Kidney Plasma Membrane Vacuolar H+-ATPases: Proton Pumps Responsible for Bicarbonate Transport, Urinary Acidification, and Acid-Base Homeostasis

  • Chapter
Organellar Proton-ATPases

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

To maintain acid-base homeostasis, the kidney must reabsorb all of the 4500 millimoles of bicarbonate filtered by the glomerulus and regenerate the approximately 70 millimoles of bicarbonate consumed by daily metabolism.1, 2 The kidney accomplishes both bicarbonate reabsorption and regeneration by using hydrogen ion secretion,1, 2 and vacuolar H+-ATPases residing on the plasma membrane have an important or essential role in these processes in several nephron segments.3, 9 The plasma membrane vacuolar H+-ATPases differ from vacuolar H+-ATPases of intracellular organelles in several ways. The plasma membrane vacuolar H+-ATPase in hydrogen ion-transporting renal epithelial cells reside at high densities,10 and they have a polarized distribution11, 12 that allows for vectorial secretion of hydrogen ion. The plasma membrane vacuolar H+-ATPases of the nephron are also subject to physiologic regulation3, 8, 13 that allows the kidney to preserve acid-base balance.

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Authors
  1. Stephen L. Gluck
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  2. Raoul D. Nelson
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  3. Beth S. M. Lee
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  4. L. Shannon Holliday
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Gluck, S.L., Nelson, R.D., Lee, B.S.M., Holliday, L.S., Iyori, M. (1995). Properties of Kidney Plasma Membrane Vacuolar H+-ATPases: Proton Pumps Responsible for Bicarbonate Transport, Urinary Acidification, and Acid-Base Homeostasis. In: Organellar Proton-ATPases. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22265-2_6

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