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Circadian Rhythms and Depression: Clinical and Experimental Models

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Physiology and Pharmacology of Biological Rhythms

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 125))

Abstract

In this chapter we review clinical and experimental evidence linking biological rhythms and affective state, and explore possible mechanisms underlying these relationships. Alterations in circadian rhythmicity have been observed in association with mood disorders (Anderson and Wirz-Justice 1991; Wirz-Justice 1995) as well as in putative animal models of depression and/or altered affective state (Rosenwasser 1992). However, much of the evidence for covariation of chronobiological and affective parameters is correlative, and the causal bases for such observations have not been fully elucidated.

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Authors
  1. A. M. Rosenwasser
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  2. A. Wirz-Justice
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Editors and Affiliations

  1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, BA1 7AY, Bath, UK

    Peter H. Redfern BPharm, PhD

  2. Instituts für Pharmakologie und Toxikologie Fakultät für klinische Medizin Mannheim, Universität Heidelberg, Maybachstr. 14-16, 68169, Mannheim, Germany

    B. Lemmer (Direktor) (Direktor)

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© 1997 Springer-Verlag Berlin Heidelberg

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Rosenwasser, A.M., Wirz-Justice, A. (1997). Circadian Rhythms and Depression: Clinical and Experimental Models. In: Redfern, P.H., Lemmer, B. (eds) Physiology and Pharmacology of Biological Rhythms. Handbook of Experimental Pharmacology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09355-9_17

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  • DOI: https://doi.org/10.1007/978-3-662-09355-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-08265-8

  • Online ISBN: 978-3-662-09355-9

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