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SPOT Synthesis — Scope of Applications

  • Chapter
Peptide Arrays on Membrane Supports

Part of the book series: Springer Lab Manuals ((SLM))

Abstract

The currently very successful paradigm in scientific research of applying a systematic empirical search rather than an iterative rational design to solve complex scientific questions heavily relies on technologies that allow for a rapid and comprehensive screening of diverse types of molecular probes. Combinatorial chemical or biological synthesis applied to molecular biology, immunology and drug discovery was the technology that paved the way (Gallop et al. 1994). Massive miniaturization and automation are central and relevant topics in the further development of these technologies. A steady increase in the number of probes and samples that can be screened together with further reductions in the assay dimensions and costs readily allows for many new applications.

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Appendix: SPOT Bibliography

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Author notes

  1. Jens Schneider-Mergener

    Present address: Jerini AG, Rudower Chaussee 4, 12489, Berlin, Germany

Authors and Affiliations

  1. AG Molecular Recognition, GBF (German Research Centre for Biotechnology), Mascheroder Weg 1, 38124, Braunschweig, Germany

    Ronald Frank

  2. Institut für Medizinische Immunologie, Medizinische Fakultät, Humboldt-Universität zu Berlin, Berlin, Germany

    Jens Schneider-Mergener

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  1. Ronald Frank
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Editors and Affiliations

  1. Forschungsstelle Hantaviren, Heidelberger Akademie der Wissenschaften, Germany

    Joachim Koch

  2. Institut für Molekulare Genetik, Universität Heidelberg, Germany

    Michael Mahler

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Frank, R., Schneider-Mergener, J. (2002). SPOT Synthesis — Scope of Applications. In: Koch, J., Mahler, M. (eds) Peptide Arrays on Membrane Supports. Springer Lab Manuals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09229-3_1

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  • DOI: https://doi.org/10.1007/978-3-662-09229-3_1

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