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The Gene Is Dead — Long Live the Gene! Conceptualizing Genes the Constructionist Way

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Sociobiology and Bioeconomics

Part of the book series: Studies in Economic Ethics and Philosophy ((SEEP))

Abstract

Mae-Wan Ho (1988) pointed out that it is a particular problem of contemporary biology that it destroys the “Unity of Nature” by looking through the “Neo-Darwinian looking glass”. The “Unity of Nature” was, and is, a fact of immediate experience for many civilizations past and present. The history of science indicates, however, that science “is concerned with separating and reducing this unity into ever smaller and smaller fragments of which nature somehow must be glued together.” Ho continues: It is a history, not only of fragmentation, but of our own alienation from nature.“ Not only the inorganic world has become reduced to mechanisms and atoms, but the organic world as well. In this process it is “Neo-Darwinism which dealt the final blow in disintegrating the organism to a mere collection of particles (genes) shuffled by blind selective ‘forces’.” The result is that “....humanity [is left] to the dilemma of a disembodied and hence impotent mind pitched against the mindless automation of a body controlled by genes whose sole imperative is to replicate.” In opposition to this approach, Ho demands that we return to a rival tradition “that resolutely resists fragmentation in favour of integration and process.” Because: “once we begin to see biology again in the light of nature’s unity, mind and body will become reunited through processes embracing every level from the sociocultural to the molecular. The organism itself — its functions, volitions and actions — will then be rightly perceived, not as the sole consequence of natural selection, but as a focus of being immanent to process and emerging simultaneously with it.” (Ho 1988, p. 117f.). The organism becomes relocated within nature.

For numerous discussions and support I want to thank Prof. Dr. Michael Drieschner, Norbert Held and Romy Tajon. In addition, I am very obliged to Dr. Barbara Alexius for her help in proof-reading the English version of my manuscript.

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References

  • Amundson, R.: “Two Concepts of Constraint: Adaptationism and the Challenge from Developmental Biology”, Philosophy of Science,61 (1994), pp. 556578.

    Google Scholar 

  • Aristoteles: ’Metaphysik Z’. Text, translation and commentary by M. Frede/G. Patzig, München (C.H. Beck) 1988.

    Google Scholar 

  • Bowler, P.J.: The Mendelian Revolution. The Emergence of Hereditary Concepts in Modern Science and Society,London (The Athlone Press) 1989.

    Google Scholar 

  • Boyd, A.: “Plant Switches on Genes in Response to Touch”, New Scientist,28 (1990), p. 40.

    Google Scholar 

  • Brunner, H.G. et al. (1993a): “Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamino Oxidase A”, Science,262 (1993a), pp. 578–580.

    Google Scholar 

  • Brunner, H.G. et al. (1993b): “X - linked Borderline Mental Retardation with Prominent Behavioral Disturbance: Phenotype, Genetic Localization, and Evidence for disturbed Monoamino Metabolism”, American Journal of Human Genetics,52 (1993b), pp. 1032–1039.

    Google Scholar 

  • Burian, R. M.: “On Conceptual Change in Biology: The Case of the Gene”, in: D.J. Depew, B.H. Weber (Eds.): Evolution at a Crossroads,Cambridge, Mass./ London (MIT Press) 21986, pp. 21–42.

    Google Scholar 

  • Carlson, E. A.: “Defining the Gene: An Evolving Concept”, American Journal of Human Genetics,49 (1991), pp. 475–487.

    Google Scholar 

  • Daly, M.: “Contentious Genes: A Commentary on The Selfish Gene by Richard Dawkins”, Journal of Social Biological Structure,3 (1980), pp. 77–81.

    Google Scholar 

  • Falk, R.: “The Gene in Search of an Identity”, Human Genetics,68 (1984), pp. 195–204.

    Google Scholar 

  • Falk, R.: “The Dominance of Traits in Genetic Analysis”, Journal of the History of Biology,24 (1991), pp. 457–484.

    Google Scholar 

  • Fogle, T.: “Are Genes Units of Inheritance?”, Biology and Philosophy,5 (1990), pp. 349–371.

    Google Scholar 

  • Goodwin, B.: How the Leopard Changed its Spots. The Evolution of Complexity,New York et al. (Charles Scribner s Sons) 1994.

    Google Scholar 

  • Gray, R.: “Death Of the Gene: Developmental Systems Strike Back”, in: P. GRIFFITHS (Ed.): Trees of Life,Dordrecht/Boston/London (Kluwer) 1992, pp. 165209.

    Google Scholar 

  • Griffiths, P. E., Gray, R. D.: “Developmental Systems And Evolutionary Explanations”, The Journal of Philosophy,91 (1994), pp. 277–304.

    Google Scholar 

  • Hampson, R.K., Rottman, F.M.: “Alternative Processing of Bovine Growth Hormone mRNA: Nonsplicing of the Final Intron Predicts a High Molecular Weight Variant of Bovine Growth Hormone”, Proceedings of the National Academy of Science,84 (1987), pp. 2673–2677.

    Google Scholar 

  • Hanson, M. R.: “Protein Products of Incompletely Edited Transcripts Are Detected in Plant Mitochiondria”, The Plant Cell,8 (1996), pp. 1–3.

    Google Scholar 

  • Hanson, M., Sutton, C. A., Lu, B.: “Plant Organelle Gene Expression: Altered by RNA Editing”, Trends in Plant Science,1 (1996), pp. 57–64.

    Google Scholar 

  • Herbert, A.: “RNA editing, Introns and Evolution”, TIG - Trends in Genetics,12 (1996), pp. 6–8.

    Google Scholar 

  • Ho, M.-W.: On not Holding Nature Still: Evolution by Process, not by Consequence“, in: M.-W. Ho, S. W. Fox (Eds.): Evolutionary Processes and Metaphors, Chichester et al. (Wiley) 1988, pp. 117–144.

    Google Scholar 

  • Ho, M.-W., Fox, S. W.: “Processes and Metaphors in Evolution”, in: M.-W. Ho, S. W. Fox (Eds.): Evolutionary Processes and Metaphors, Chichester et al. (Wiley) 1988, pp. 1–16.

    Google Scholar 

  • Kitcher, P.: “Genes”, British Journal of Philosophy of Science,33 (1982), pp. 337–359.

    Google Scholar 

  • Kitcher, P.: “Gene: Current Usages”, in: E. Fox Keller, E.A. Lloyd (Eds.): Keywords in Evolutionary Biology,Cambridge, Mass./London (Harvard Univ. Press) 1992, pp. 128–131.

    Google Scholar 

  • Knippers, R.: Molekulare Genetik,Stuttgart, New York (Thieme)71997.

    Google Scholar 

  • Lee, W., Haslinger, A., Karin, M., Tijan, R.: “Activation of Transcription by Two Factors That Bind Promoter and Enhancer Sequences of the Human Metallothionein Gene and SV40”, Nature,325 (1987), pp. 368–372.

    Google Scholar 

  • Levin, B.: Genes,New York et. al. (Wiley) 1985.

    Google Scholar 

  • Levis, R., Hazelrigg, T., Rubin, G.M.: “Effects of Genomic Position on the Expression of Transduced Copies of White Gene of Drosophila”, Science,229 (1985), pp. 558–561.

    Google Scholar 

  • Lewontin, R.: Biology as Ideology: The Doctrine of DNA,New York (Harper Collins) 1993.

    Google Scholar 

  • Mccain, R. A.: “Critical Reflections on Sociobiology”, Review of Social Economy,38 (1980), pp. 123–139.

    Google Scholar 

  • Neumann-Held, E. M.: “Die moderne Biologie auf der Suche nach dem ‘Heiligen Gral” [“Modern Biology in Seach for the Holy Grail”], in: T. Fischer, R. Seising (Eds.): Wissenschaft und ôffentlichkeit [Science and the Public],Frankfurt/M. (Peter Lang) 1996, pp. 137–163.

    Google Scholar 

  • Neumann-Held, E. M.: “ ‘Gene’ können nicht alles erklären”, Universitas,52 (1997), pp. 469–479.

    Google Scholar 

  • Oyama, S.: The Ontogeny of Information. Developmental Systems and Evolution,Cambridge et. al. (Cambridge University Press) 1985.

    Google Scholar 

  • Oyama, S.: “Evolutionary and Developmental Formation: Politics of the Boundary”, in this book pp. 79–104.

    Google Scholar 

  • Phreaner, C. G., Williams, M. A., Mulligan, R. M.: “Incomplete Editing of rps12 Transcripts Results in the Synthesis of Polymorphic Polypeptides in Plant Mitochondria”, The Plant Cell,8 (1996), pp. 107–117.

    Google Scholar 

  • Pollard, J. W.: New Genetic Mechanisms and their Implications for the Formation of New Species“, in: M.-W. Ho, S. W. Fox (Eds.): Evolutionary Processes and Metaphors,Chichester et al. (Wiley) 1988, pp. 63–84.

    Google Scholar 

  • Portin, P.: “The Concept of the Gene: Short History and Present Status”, The Quarterly Review of Biology,68 (1993), pp. 173–223.

    Google Scholar 

  • Rehmann-Sutter, C.: “Was ist ein Lebewesen? - Zur philosophischen Herausforderung durch die Molekularbiologie” (“What is a Living Being? - Toward the philosophical challenge of molecular biology], Scheidewege: Jahresschrift für skeptisches Denken,23 (1993/1994), pp. 142–159.

    Google Scholar 

  • Sterelny, K., Kitcher, P.: “The Return of the Gene”, The Journal of Philosophy,85 (1988), pp. 339–361.

    Google Scholar 

  • Waters, C. K.: “Genes made Molecular”, Philosophy of Science,61 (1994), pp. 163–185.

    Google Scholar 

  • Watson, J. D., Crick, F. H.C. (1953a): “Molecular Structure of Nucleic Acids: a Structure for Deoxyribose Nucleic Acid”, Nature,171 (1953a), pp. 737–738.

    Google Scholar 

  • Watson, J. D., Crick, F. H.C. (1953b): “Genetical Implications of the Structure of Deoxyribonucleic Acid”, Nature,171 (1953b), pp. 964–967.

    Google Scholar 

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Neumann-Held, E.M. (1999). The Gene Is Dead — Long Live the Gene! Conceptualizing Genes the Constructionist Way. In: Koslowski, P. (eds) Sociobiology and Bioeconomics. Studies in Economic Ethics and Philosophy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03825-3_6

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  • DOI: https://doi.org/10.1007/978-3-662-03825-3_6

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