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The Importance of Protein Co- and Post-Translational Modifications in Proteome Projects

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Proteome Research: New Frontiers in Functional Genomics

Part of the book series: Principles and Practice ((PRINCIPLES))

Abstract

Any protein in a proteome can be modified by co- and post-translational modifications. There are literally dozens of different types of such modifications, all of which can influence a protein’s charge, hydrophobicity, conformation and/or stability. Hence, the “one-gene-one-polypeptide” paradigm is now outdated as we understand that in both eukaryotes and prokaryotes the polypeptide translation of many genes is modified to create multiple gene products from a single DNA sequence (Fig. 4.1). Well-documented examples include the differential glycosylation of Thy-1 expressed in different tissues (Parekh et al. 1987) and the differential RNA splicing of N-CAM (Cunningham et al. 1987).

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Authors
  1. Andrew A. Gooley
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  2. Nicolle H. Packer
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Editors and Affiliations

  1. Laboratoire Central de Chimie Clinique, Hôpitaux Universitaires de Genève et Université de Genève, 24, rue Micheli-du-Crest, 1211, Genève 14, Switzerland

    Marc R. Wilkins  & Denis F. Hochstrasser  & 

  2. Australian Proteome Analysis Facility and MUCAB, School of Biological Sciences, Macquarie University, 2109, Sydney, NSW, Australia

    Keith L. Williams

  3. Division d’Informatique Médicale, Hôpitaux Universitaires de Genève, 24, rue Micheli-du-Crest, 1211, Genève 14, Switzerland

    Ron D. Appel

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Gooley, A.A., Packer, N.H. (1997). The Importance of Protein Co- and Post-Translational Modifications in Proteome Projects. In: Wilkins, M.R., Williams, K.L., Appel, R.D., Hochstrasser, D.F. (eds) Proteome Research: New Frontiers in Functional Genomics. Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03493-4_4

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  • DOI: https://doi.org/10.1007/978-3-662-03493-4_4

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  • Print ISBN: 978-3-540-62753-1

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