Abstract
Desmosomes are intercellular junctions found in virtually all epithelia and in myocardium which is of mesenchymal origin. Whilst the importance of desmosomes and their attached cytoplasmic filaments in strengthening such tissue is well accepted, their wider role in epithelial organization and pathology remains largely unexplored. Desmosomes constitute a large and immediately recognizable portion of the cell membrane which is specialized both for adhesion and filament binding, universal cell properties whose molecular basis remains obscure.
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References
Allen TD, Potten CS (1975) Desmosomal form, fate and function in mammalian epidermis. J Ultrastruct Res 51: 94–105
Barnett ML, Szabo G (1973) Effect of vitamin A on epithelial morphogenesis in vitro. Exp Cell Res 76: 118–126
Bell CM, Skerrow CJ (1984) Factors affecting the binding of lectins to normal human skin. Br J Dermatol 111: (517–526)
Benedetti EL, Emmelot P (1968) Structure and function of plasma membranes isolated from liver. In: Dalton AF, Hagenau F (eds) The membranes. Academic Press, London New York, pp 33–120
Bladon PT, Taylor M, Wood EJ, Cunliffe WJ (1983) Isolation, characterization and comparison of mammalian epidermal prekeratins. Comp Biochem Physiol [B] 74: 653–660
Borysenko JZ, Revel J-P (1973) Experimental manipulation of desmosome structure. J Anat 137: 403–422
Breathnach AS (1971) Embryology of human skin. A review of ultrastructural studies. J Invest Dermatol 57: 133–143
Breathnach AS (1975) Aspects of epidermal ultrastructure. J Invest Dermatol 65: 2–15
Breathnach AS, Goodman T, Stolinski C, Gross M (1973) Freeze-fracture replication of cells of stratum corneum of human epidermis. J Anat 114: 65–81
Brody I (1968) An electron microscopic study of the junctional and regular desmosomes in normal human epidermis. Acta Derm Venereol (Stockh) 48: 290–302
Brookes DE, Millar JS, Seaman GVF (1967) Some physiochemical factors relevant to cellular interactions. J Cell Physiol 69: 155–168
Caputo R (1980) A novel view of the dermal—epidermal junction. Am J Dermatopath 2: 357–361
Caputo R, Pelechetti D (1977) The junctions of normal human epidermis. A freeze-fracture study. J Ultrastruct Res 61: 44–61
Chambers R, Renyi GS (1925) The structure of the cells in tissues as revealed by microdissection. Am J Anat 35: 385–402
Christophers E (1971) Cellular architecture of the stratum corneum. J Invest Dermatol 56: 165–169
Christophers E, Wolff HH (1975) Differential formation of desmosomes and hemidesmosomes in epidermal cell cultures treated with retinoic acid. Nature 256: 209–210
Cohen SM, Gorbsky GJ, Steinberg MS (1980) Monoclonal antibodies to the intercellular glycoprotein components of desmosomes. J Cell Biol 87: 88a
Cohen SM, Gorbsky GJ, Steinberg MS (1983) lmmunochemical characterization of related families of glycoproteins in desmosomes. J Biol Chem 90: 243–248
Cowin P, Garrod DR (1983) Antibodies to epithelial desmosomes show wide tissue and species cross-reactivity. Nature 302: 148–150
Cowin P, Mattey DM, Garrod DR (1984a) Distribution of desmosomal components in the tissues of vertebrates, studied by fluorescent antibody staining. J Cell Sci 66: 119–132
Cowin P, Mattey D, Garrod DR (1984b) Identification of desmosomal surface components (desmocollins) and inhibition of desmosome formation by specific Fab. J Cell Sei 70: 41–60
Dembitzer HM, Herz F, Schermer A, Wooley RC, Koss LG (1980) Desmosome development in an in vitro model. J Cell Biol 85: 695–702
Docherty RJ, Edwards JG, Garrod DR (1984) Chick embryonic pigmented retina is one of the group of epithelioid tissues which lack cytokeratins and desmosomes and have intermediate filaments composed of vimentin. J Cell Sci 71: 61–74
Drochmans P, Freudenstein C, Wanson J-C, Laurent K, Keenan TW, Stadler J, Leloup R, Franke WW (1978) Structure and composition of desmosomes and tonofilaments isolated from calf muzzle epidermis. J Cell Biol 80: 231–247
Edwards JG (1983) The biochemistry of cell adhesion. Prog Surf Sei 13: 125–196
Elias PM, Fritsch PO (1983) Exfoliatin and pathogenesis of blister formation. In: Goldsmith LA (ed) Biochemistry and physiology of skin, vol II. Oxford Univ Press, New York Oxford, pp 1037–1055
Farquhar MG, Palade G (1963) Junctional complexes in various epithelia. J Cell Biol 19: 375–412
Fentiman I, Taylor-Papadimitriou J, Stoker M (1976) Selective contact-dependent cell communication. Nature 264: 760–762
Franke WW, Schmid E, Grund C, Mueller H, Engelbrecht I, Moll R, Stadler J, Jarasch ED (1981) Antibodies to high molecular weight polypeptides of desmosomes: specific localisation of a class of junctional proteins in cells and tissues. Differentiation 20: 217–241
Franke WW, Moll R, Schiller DL, Schmid E, Kartenbeck J, Mueller H (1982) Desmoplakins of epithelial and myocardial desmosomes are immunologically and biochemically related. Differentiation 23: 115–127
Franke WW, Moll R, Schiller DL, Schmid G, Kuhn C, Krepler R, Artlieb U, Denk H (1983a) Immunocytochemical identification of epithelium-derived human tumours using antibodies to desmosomal plaque proteins. Proc Natl Acad Sci USA 80: 543–547
Franke WW, Mueller H, Mittnacht S, Kapprell H-P, Jorcano JL (1983b) Significance of two desmosome plaque-associated polypeptides of molecular weights 75000 and 83000. EMBO J 2: 2211–2215
Franke WW, Kapprell H-P, Mueller H (1983 c) Isolation and symmetrical splitting of desmosomal structures in 9M urea. Eur J Cell Biol 32: 117–130
Garrod DR, Cowin P (1985) Desmosome structure and function. In: Chadwick CM (ed) Receptors in tumour immunology. Cambridge Univ Press, Cambridge
Geiger B, Schmid E, Franke WW (1983) Spatial distribution of proteins specific for desmosomes and adhaerens junctions in epithelial cells demonstrated by double immunofluorescence microscopy. Differentiation 23: 189–205
Giudice GJ, Cohen SM, Patel N, Steinberg MS (1984) Immunological comparison of desmosomal components from several bovine tissues. J Cell Biochem 26: 35–45
Goldsmith LA (1983) (ed) Biochemistry and physiology of the skin, vol I I. Oxford Univ Press, New York Oxford
Gorbsky G, Cohen SM, Shida H, Giudice GJ, Steinberg MS (1985) Isolation of the nonglycosylated proteins of desmosomes and immunolocalization of a third plaque protein: Desmoplakin III. Proc Natl Acad Sci USA 82: 810–814
Gorbsky G, Steinberg MS (1981) Isolation of the intercellular glycoproteins of desmosomes. J Cell Biol 90: 243–248
Grayson S, Elias PM (1982) Isolation and lipid biochemical characterization of stratum corneum membrane complexes: implications for the cutaneous permeability barrier. J Invest Dermatol 78: 128–135
Heaysman JEM, Pegrum SM (1973) Early contacts between fibroblasts. Exp Cell Res 78: 71–78
Hennings H, Holbrook KA (1983) Calcium regulation of cell—cell contact and differentiation of epidermal cells in culture. Exp Cell Res 143: 127–142
Hennings H, Holbrook KA, Yuspa SH (1983) Potassium mediation of calcium-induced terminal differentiation of epidermal cells in culture. J Invest Dermatol 81: 50s - 55s
Hirone T, Taniguchi S (1980) Basal lamina formation by epidermal cells in culture. In: Seiji M, Bernstein IA (eds) Biochemistry of cutaneous epidermal differentiation. Univ Tokyo Press, Tokyo
Holbrook KA, Hennings H (1983) Phenotypic expression of epidermal cells in vitro: A review. J Invest Dermatol 81: 11s - 23s
Ishimaru Y, Kudo K, Ishihara H, Hayashi H (1976) The induction of tumour cell adhesiveness and intercellular junctions by a glycoprotein of rat ascites hepatoma cell surfaces. Er J Cancer 34: 426–436
Kartenbeck J, Schmid E, Franke WW, Geiger B (1982) Different modes of internalization of proteins associated with adhaerens junctions and desmosomes: experimental separation of lateral contacts induces endocytosis of desmosomal plaque material. EMBO J 1: 725–732
Kartenbeck J, Franke WW, Moser JG, Stoffels U (1983) Specific attachment of desmin filaments of desmosomal plaques in cardiac myocytes. EMBO J 2: 735–742
Kartenbeck J, Schwechheimer K, Moll R, Franke WW (1984) Attachment of vimentin filaments to desmosomal plaques in human meningiomal cells and arachnoidal tissue. J Cell Biol 98: 1072–1081
Kelly DE (1966) Fine structure of desmosomes, hemidesmosomes and an adepidermal globular layer in developing newt epidermis. J Cell Biol 28: 51–72
Kelly DE, Kuda AM (1981) Traversing filaments in desmosomal and hemidesmosomal attachments: freeze fracture approach toward their characterisation. Anat Rec 199: 1–14
Kelly DE, Sheinvold FL (1976) The desmosome: fine structural studies with freeze-fracture replication and tannic acid staining of sectioned epidermis. Cell Tissue Res 172: 309–323
King IA, Tabiowo A (1981) Effect of tunicamycin on epidermal glycoprotein and glycosaminoglycan synthesis in vitro. Biochem J 198: 331–338
Klaus SN, Branson SH, Moellmann GE (1971) Lability of desmosomes in cell culture. J Invest Dermatol 56: 402 (Abstr)
Klein-Szanto AJP (1977) Stereologic baseline data of normal humar_ epidermis. J Invest Dermatol 68: 73–78
Krawczyk WW, Wilgram GF (1973) Hemidesmosome and desmosome morphogenesis during epidermal wound healing. J Ultrastruct Res 45: 93–101
Loomans ME, Hannon DP (1970) An electron microscopic study of the effects of subtilisin and detergents on human stratum corneum. J Invest Dermatol 55: 101–114
Luft JH (1971) Ruthenium red and violet. II Fine structural localization in animal tissues. Anat Rec 171: 369–415
McNutt MS, Weinstein RS (1973) Membrane ultrastructure of mammalian intercellular junctions. Prog Biophys Mol Biol 26: 45–101
Morejohn LC, Pratley JN (1979) Differential effects of trypsin on the epidermis of Rana catesbeiana. Cell Tissue Res 198: 349–362
Mueller H, Franke WW (1983) Biochemical and immunological characterization of desmoplak- ins I and I, the major polypeptides of the desmosomal plaque. J Mol Biol 163: 647–671
Ortonne J-P, Loning T, Schmitt D, Thivolet J (1981) Immunomorphological and ultrastructural aspects of keratinocyte migration in epidermal wound healing. Virchows Arch A 392: 217–230
Orwin DFG, Thomson RW, Flower NE (1973) Plasma membrane differentiation of keratinizing cells of the wool follicle. II Desmosomes. J Ultrastruct Res 45: 15–19
Overton J (1962) Desmosome development in normal and reassociating cells in the early chick blastoderm. Dev Biol 4: 532–548
Overton J (1968) The fate of desmosomes in trypsinized tissues. J Exp Zool 168: 203–214
Overton J (1975) Experiments with junctions of the adhaerens type. Curr Top Dev Biol 10: 1–34
Overton J (1977) Formation of junctions and cell sorting in aggregates of chick and mouse cells. Dev Biol 55: 103–116
Overton J (1979) Inhibition of desmosome formation in chick cell aggregates. J Exp Zool 209: 135–142
Overton J (1982) Inhibition of desmosome formation with tunicamycin and with lectin in corneal cell aggregates. Dev Biol 92: 66–72
Overton J, Culver N (1973) Desmosomes and their components after cell dissociation and reaggregation in the presence of cytochalasin B. J Exp Zool 185: 341–356
Overton J, Desalle R (1980) Control of desmosome formation in aggregating embryonic chick cells. Dev Biol 75: 168–175
Overton J, Kapmarski R (1975) Hybrid desmosomes in aggregated chick and mouse cells. J Exp Zool 192: 33–42
Overton J, Meyer R, Adler R (1984) Cell-cell interactions during junction formation. In: Kemp RB (ed) Matrices and differentiation. Liss, New York, in press
Pitts JD, Burk RR (1976) Specificity of junctional communication between animal cells. Nature 264: 762–764
Prunieras M, Regnier M, Woodley D (1983) Methods for cultivation of keratinocytes with an air—liquid interface. J Invest Dermatol 81: 28s - 32s
Rambourg A (1971) Morphological and histochemical aspects of glycoproteins at the surface of animal cells. Int Rev Cytol 31: 57–114
Rayns DG, Simpson FO, Ledingham JM (1969) Ultrastructure of desmosomes in mammalian intercalated disc; appearances after lanthanum treatment. J Celi Biol 42: 322–326
Revel J-P, Karnovsky MJ (1967) Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J Cell Biol 33: 7–12
Schmid E, Franke WW, Grund C, Schiller DL, Kolb H, Pauveletz N (1983) An epithelial cell line with elongated myoid morphology derived from bovine mammary gland. Exp Cell Res 146: 309–328
Shida H, Gorbsky G, Shida M, Steinberg MS (1982) Electron microscopic localization of specific carbohydrate groups in thin sections of tissues embedded in a hydrophilic resin. J Histochem Cytochem 30: 1153–1164
Shields R, Pollock K (1974) The adhesion of BHK and PyBHK cells to the substratum. Cell 3: 31–38
Shimono M, Clementi F (1977) Intercellular junctions of oral epithelium. I. Studies with freeze-fracture and tracing methods of normal rat keratinized oral epithelium. J Ultrastruct Res 56: 121–136
Skerrow CJ (1974c) The isolation and characterization of epidermal desmosomes. Thesis, Boston Univ, Boston
Skerrow CJ (1978) Intercellular adhesion and its role in epidermal differentiation. Invest Cell Pathol 1: 23–37
Skerrow CJ (1979) Selective extraction of desmosomal proteins by low ionic strength media. Biochim Biophys Acta 579: 241–245
Skerrow CJ (1980) The experimental production of high-level intraepidermal splits. Br J Dermatol 102: 75–83
Skerrow CJ, Skerrow D (1980) Desmosomes and filaments in mammalian epidermis. In: Curtis ASG, Pitts JD (eds) Cell adhesion and motility. Cambridge Univ Press, Cambridge
Skerrow CJ, Skerrow D (1984) A survey of methods for the isolation and fractionation of epidermal tissue and cells. In: Skerrow D, Skerrow CJ (eds) Methods in skin research. Wiley, London New York, pp 609–650
Skerrow CJ, Matoltsy AG (1974a) Isolation of epidermal desmosomes. J Cell Biol 63: 515–523
Skerrow CJ, Matoltsy AG (1974 b) Chemical characterization of epidermal desmosomes. J Cell Biol 63: 524–530
Skerrow D, Skerrow CJ (1983) Tonofilament differentiation in human epidermis: Isolation and polypeptide chain composition of keratinocyte subpopulations. Exp Cell Res 143: 27–35
Staehelin LA (1974) Structure and function of intercellular junctions. Int Rev Cytol 39: 191–283
Steinberg MS (1978) Cell—Cell recognition in multicellular assembly: levels of specificity. In: Curtis ASG (ed) Cell—cell recognition. Cambridge Univ Press, Cambridge, pp 25–49
Steinberg MS, Wiseman LL (1972) Do morphogenetic tissue rearrangements require active cell movements? J Cell Biol 55: 607–615
Wiseman LL, Strickler J (1981) Desmosome frequency: experimental alteration may correlate with differential cell adhesion. J Cell Sci 49: 217–223
Wolff K, Wolff-Schreiner EC (1976) Trends in electron microscopy of skin. J Invest Dermatol 67: 39–57
Zerban H, Franke WW (1978) Modified desmosomes in cultured epithelial cells. Cytobiologie 18: 360–373
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Skerrow, C.J. (1986). Desmosomal Proteins. In: Bereiter-Hahn, J., Matoltsy, A.G., Richards, K.S. (eds) Biology of the Integument. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00989-5_38
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DOI: https://doi.org/10.1007/978-3-662-00989-5_38
Publisher Name: Springer, Berlin, Heidelberg
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