Zusammenfassung
Lokalanästhetika sind Pharmaka, die die Erregungsleitung eines Nerven reversibel unterbrechen. Dabei sind die sog. klassischen Lokalanästhetika von lokalanästhetisch wirkenden Substanzen zu unterscheiden.
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Literatur
Abdel-Salam AR, Vonwiller JB, Scott DB (1975) Evaluation of etidocaine in extradural block. Br J Anaesth 47: 1081–1086
Aberg G (1972) Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacol Toxicol 31: 273–286
Abouleish EI (1987) Epinephrine improves the quality of spinal hyperbaric bupivacaine for Cesarean section. Anesth Analg 66: 395–400
Akerman B, Astrom A, Ross S, Tele A (1966) Studies on the absorption, distribution and metabolism of labelled prilocaine and lidocaine in some animal species. Acta Pharmacol Toxicol 24: 389–403
Akerman B, Hellberg IB, Trossvik C (1988) Primary evaluation of the local anaesthetic properties of the amino amide agent ropivacaine (LEA 103). Acta Anaesthesiol Scand 32: 571–578
Akerman B, Persson H, Tegner C (1967) Local anaesthetic properties of the optically active isomers of prilocaine ( Citanest ). Acta Pharmacol Toxicol 25: 233–241
Akerman B, Ross S (1970) Stereospecificity of the enzymatic biotransformation of the enantiomers of prilocaine ( Citanest ). Acta Pharmacol Toxicol 28: 445–453
Albright GA (1979) Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 51: 285–287
Appleyard TN, Witt A, Atkinson RE, Nicholas ADG (1974) Bupivacaine carbonate and bupivacaine hydrochloride: a comparison of blood concentrations during epidural blockade for vaginal surgery. Br J Anaesth 46: 530–533
Aps C, Reynolds F (1976) The effect of concentration on vasoactivity of bupivacaine and lignocaine. Br J Anaesth 48: 1171–1174
Arhem P, Rydquist B (1986) The mechanism of action of ketamine on the myelinated nerve membrane. Eur J Pharmacol 126: 245–251
Arthur GR (1987) Pharmacokinetics of local anesthetics. In: Strichartz GR (ed) Local anesthetics. Springer, Berlin Heidelberg New York Tokyo, pp 165–186
Arthur GR, Feldman HS, Covino BG (1988) Comparative pharmacokinetics of bupivacaine and ropivacaine, a new amide local anesthetic. Anesth Analg 67: 1053–1058
Auberger HG, Niesei HC (1990) Praktische Lokalanästhesie–regionale Schmerztherapie, 5. Aufl. Thieme, Stuttgart, S 1–301
Axelsson K, Widman B (1981) Blood concentration of lidocaine after spinal anaesthesia using lidocaine and lidocaine with adrenaline. Acta Anaesthesiol Scand 25: 240–245
Bachmann B, Biscoping J (1985) Plasmaspiegel von Bupivacain nach versehentlicher intravasaler Injektion über einen Periduralkatheter. Reg Anaesth 8: 13–14
Bachmann-Mennenga B, Biscoping J, Adams HA, Menges T, Krumholz W, Hempelmann G (1990) Die Bedeutung des Entnahmeortes bei der Bestimmung von Lokalanaesthetikakonzentrationen im Plasma am Beispiel von Bupivacain 0,75%. Reg Anaesth 13: 16–20
Bader AM, Datta S, Flanagan H, Covino BG (1989) Comparison of bupivacaine-and ropivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 68: 724–727
Barsa J, Batra M, Fink BR, Sumi SM (1982) A comparative in vivo study of local neurotoxicity of lidocaine, bupivacaine, 2-chloroprocaine, and a mixture of 2-chloroprocaine and bupivacaine. Anesth Analg 61: 961–967
Bedder MD, Kozody R, Craig DB (1988) Comparison of bupivacaine and alkalinized bupivacaine in brachial plexus anesthesia. Anesth Analg 67: 48–52
Bennett AL, Wagner JC, Mclntyre AR (1942) The determination of local-anesthetic potency by observation of nerve action-potentials. J Pharmacol Exp Ther 75: 125–136
Benoit E, Carratu MR, Dubois JM, Mitolo-Chieppa D, Preziosi P (1987) Electrophysiological studies of the effects of the general anaesthetic etomidate on frog myelinated nerve fibre. Br J Pharmacol 90: 7–14
Benzon HT, Toleikis JR, Dixit P, Goodman I, Hill JA (1993) Onset, intensity of blockade and somatosensory evoked potential changes of the lumbosacral dermatomes after epidural anesthesia with alkalinized lido-caine. Anesth Analg 76: 328–332
Bernards CM, Carpenter RL, Kenter ME, Brown DL, Rupp SM, Thompson GE (1989) Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. Anesthesiology 71: 711–717
Bernards CM, Carpenter RL, Rupp SM, Brown DL, Morse BV, Morell RC, Thompson GE (1989) Effect of midazolam and diazepam premedication on central nervous system and cardiovascular toxicity of bupivacaine in pigs. Anesthesiology 70: 318–323
Berrisford RG, Sabanathan S, Mearns AJ, Clarke BJ, Hamdi A (1993) Plasma concentrations of bupivacaine and its enantiomers during continuous extrapleural intercostal nerve block. Br J Anaesth 70: 201–204
Blair MR (1975) Cardiovascular pharmacology of local anaesthetics. Br J Anaesth 47: 247–252
Block A, Covino BG (1981) Effect of local anesthetic agents on cardiac conduction and contractility. Reg Anesth 6: 55–61
Bokesch PM, Raymond SA, Strichartz GR (1987) Dependence of lidocaine potency on pH and pC02. Anesth Analg 66: 9–17
Bridenbaugh PO, Greene NM (1988) Spinal (subarachnoid) neural blockade. In: Cousins MJ, Bridenbaugh PO (eds) Neural blockade in clinical anesthesia and management of pain. Lippincott, Philadelphia, pp 213–251
Bromage PR (1962) Spread of analgesic solutions in the epidural space and their site of actions: a statistical study. Br J Anaesth 34: 161–178
Bromage PR (1975) Mechanism of action of extradural analgesia. Br J Anaesth 47: 199–212
Bromage PR (1978) Epidural analgesia. Saunders, Philadelphia, pp 1–746
Bromage PR, Burfoot MF, Crowell DE, Pettigrew RT (1964) Quality of epidural blockade I: influence of physical factors. Br J Anaesth 36: 342–352
Bromage PR, Burfoot MF, Crowell DE, Truant AP (1967) Quality of epidural blockade III: carbonated local anaesthetic solutions. Br J Anaesth 39: 197–209
Bromage PR, Gertel M (1970) An evaluation of two new local anaesthetics for major conduction block. Can Anaesth Soc J 17: 557–564
Brown DL, Carpenter RL, Thompson GE (1990) Comparison of 0.5% ropivacaine and 0.5% bupivacaine for epidural anesthesia in patients undergoing lower-extremitiy surgery. Anesthesiology 72: 633–636
Brown DT, Morison DH, Covino BG, Scott DB (1980) Comparison of carbonated bupivacaine and bupivacaine hydrochloride for extradural anaesthesia. Br J Anaesth 52: 419–422
Buckley FP, Neto GD, Fink BR (1985) Acid and alkaline solutions of local anesthetics: duration of nerve block and tissue pH. Anesth Analg 64: 477–482
Buffington CW (1989) The magnitude and duration of direct myocardial depression following intracoronary local anesthetics: a comparison of lidocaine and bupivacaine. Anesthesiology 70: 280–287
Burm AGL (1985) Pharmacokinetics and clinical effects of lidocaine and bupivacaine following epidural and subarachnoid administration in man. ICG, Dordrecht, pp 1–187
Burn JM, Guyer PB, Langdon L (1973) The spread of solutions injected into the epidural space: a study using epidurograms in patients with the lumbosciatic syndrome. Br J Anaesth 45: 338–345
Butterworth JF, Brownlow RC, Leith JP, Prielipp RC, Cole LR (1993) Bupivacaine inhibits cyclic-3,5-adenosine monophosphate production–A possible contributing factor to cardiovascular toxicity. Anesthesiology 79: 88–95
Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthesia: a review. Anesthesiology 72: 711–734
Byers MR, Fink BR, Kennedy RD, Middaugh ME, Hendrickson AE (1973) Effects of lidocaine on axonal morphology, microtubules, and rapid transport in rabbit vagus nerve in vitro. J Neurobiol 4: 125–143
Cahalan MD, Aimers W (1979) Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin. Biophys J 27: 39–56
Catchlove RFH (1972) The influence of CO2 andpH on local anesthetic action. J Pharmacol Exp Ther 181: 298–309
Catchlove RFH (1973) Potentiation of two different local anaesthetics by carbon dioxide. Br J Anaesth 45: 471–474
Cederholm I, Evers H, Lófstróm JB (1991) Effect of intradermal injection of saline or a local anaesthetic agent on skin blood flow–a methodological study in man. Acta Anaesthesiol Scand 35: 208–215
Cederholm I, Evers H, Lófstróm JB (1992) Skin blood flow after intradermal injection of ropivacaine in various concentrations with and without epinephrine evaluated by laser Doppler flowmetry. Reg Anesth 17: 322–328
Chadwick HS (1985) Toxicity and resuscitation in lidocaine-or bupivacaine-infused cats. Anesthesiology 63: 385–390
Chamberlain DP, Chamberlain BDL (1986) Changes in the skin temperature of the trunk and their relationship to sympathetic blockade during spinal anesthesia. Anesthesiology 65: 139–143
Chambers WA, Littlewood DG, Logan MR, Scott DB (1981) Effect of added epinephrine on spinal anesthesia with lidocaine. Anesth Analg 60: 417–420
Clarkson CW, Hondeghem LM (1985) Mechanism for bupivacaine depression of cardiac conduction: fast block of Na-channels during the action potential with slow recovery from block during diastole. Anesthesiology 62: 396–405
Cohen SE, Thurlow A (1979) Comparison of a chloro-procaine-bupivacaine mixture with chloroprocaine and bupivacaine used individually for obstetric epidural analgesia. Anesthesiology 51: 288–292
Concepción M, Arthur GR, Steele SM, Bader AM, Covino BG (1990) A new local anesthetic, ropivacaine–its epidural effects in humans. Anesth Analg 70: 80–85
Condouris GA, Shakalis A (1964) Potentiation of the nerve-depressant effect of the local anaesthetics by carbon dioxide. Nature (London) 204: 57–59
Corke BC, Carlson CG, Dettbarn WD (1984) The influence of 2-chloroprocaine on the subsequent analgesic potency of bupivacaine. Anesthesiology 60: 25–27
Courtney KR (1975) Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA 968. J Pharmacol Exp Ther 195: 225–236
Cousins MJ, Bromage PR (1971) A comparison of the hydrochloride and carbonated salts of lignocaine for caudal analgesia in out-patients. Br J Anaesth 43: 1149–1155
Cousins MJ, Bromage PR (1988) Epidural neural blockade. In: Cousins MJ, Bridenbaugh PO (eds) Neural blockade in clinical anesthesia and management of pain. Lippincott, Philadelphia, pp 253–360
Cousins MJ, Mather LE (1984) Intrathecal and epidural administration of opioids. Anesthesiology 61: 276–310
Covino BG (1986) Pharmacology of local anaesthetic agents. Br J Anaesth 58: 701–716
Covino BG (1987) Toxicity and systemic effects of local anesthetic agents. In: Strichartz GR (ed) Local anesthetics. Springer, Berlin Heidelberg New York Tokyo, pp 187–212
Covino BG (1988) Clinical pharmacology of local anesthetic agents. In: Cousins MJ, Bridenbaugh PO (eds) Neural blockade in clinical anesthesia and management of pain. Lippincott, Philadelphia, S 111–144
Covino BG (1990) General considerations, toxicity and complications of local anaesthesia. In: Nimmo WS, Smith G (eds) Anaesthesia. Blackwell, Oxford, pp 1011–1033
Covino BG, Marx GF, Finster M, Zsigmond EK (1980) Prolonged sensory/motor deficits following inadvertent spinal anesthesia. Anesth Analg 59: 399–400
Crandell JT, Kotelko DM (1985) Cardiotoxicity of local anesthetics during late pregnancy. Anesth Analg 64: 204 (Abstract)
Cunningham NL, Kaplan JA (1974) A rapid-onset, long-acting regional anesthetic technique. Anesthesiology 41: 509–511
Cusick JF, Myklebust JB, Abram SE (1980) Differential neural effects of epidural anesthetics. Anesthesiology 53: 299–306
Dahl JB, Simonsen L, Mogensen T, Henriksen JH, Kehlet H (1990) The effect of 0.5% ropivacaine on epidural blood flow. Acta Anaesthesiol Scand 34: 308–310
Davis NL, de Jong RH (1982) Successful resuscitation following massive bupivacaine overdose. Anesth Analg 61: 62–64
Dawkins CJM (1969) An analysis of the complications of extradural and caudal block. Anaesthesia 24: 554–563
de Jong RH (1977) Local anesthetics, 2nd edn. Thomas, Springfield, 111, pp 1–338
de Jong RH, Bonin JD (1980) Deaths from local anesthetic induced convulsions in mice. Anesth Analg 59: 401–405
de Jong RH, Bonin JD (1981) Mixtures of local anesthetics are no more toxic than the parent drugs. Anesthesiology 54: 177–181
Defalque RJ, Stoelting VK (1966) Latency and duration of action of some local anesthetic mixtures. Anesth Analg 45: 106–116
Denson DD, Bridenbaugh PO, Turner PA, Phero JC (1983) Comparison of neural blockade and pharmacokinetics after subarachnoid lidocaine in the rhesus monkey. II: Effects of volume, osmolality and baricity. Anesth Analg 62: 995–1001
Dhuner KG, Harthon JGL, Herbring BG, Lie T (1965) Blood levels ov mepivacaine after regional anaesthesia. Br J Anaesth 37: 746–752
Diallo B, Nolte H (1984) Zur Frage der Equipotenz von Etidocain and Bupivacain bei der Periduralanaesthesie. Reg Anaesth 7: 33–38
DiFazio CA, Carron H, Grosslight KR, Moscicki JC, Bolding WR, Johns RA (1986) Comparison of pH- adjusted lidocaine solutions for epidural anesthesia. Anesth Analg 65: 760–764
Dirkes WE, Gregg RV, Raj PP, Coyle DE, Denson DD (1985) Clinical significance of drug displacement interactions between amide local anesthetics. Anesthesiology 63: A210 (Abstract)
Dodt HU, Strichartz GR, Zimmermann M (1983) Phenol solutions differentially block conduction in cutaneous nerve fibers of the cat. Neurosci Lett 42: 323–327
Eckstein KL, Vicente-Eckstein A, Steiner R, Missler U (1978) Klinische Erprobung von Bupivacain-C02. Reg Anaesth 1: 27–31
Edwards DJ, Lalka D, Cerra F, Slaughter RL (1982) Alpharacid glycoprotein concentration and protein binding in trauma. Clin Pharmacol Ther 31: 62–67
Eisenach JC, Grice SC, Dewan DM (1987) Epinephrine enhances analgesia produced by epidural bupivacaine during labor. Anesth Analg 66: 447–451
Englesson S (1974) The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents. I. Acta Anaesthesiol Scand 18: 79–87
Englesson S, Grevsten S (1974) The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents. II. Acta Anaesthesiol Scand 18: 88–103
Erdemir HA, Soper LE, Sweet RB (1965) Studies of factors affecting peridural anesthesia. Anesth Analg 44: 400–404
Feldman HS, Arthur GR, Covino BG (1989) Comparative systemic toxicity of convulsant and supracon-vulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. Anesth Analg 69: 794–801
Feldman HS, Arthur GR, Pitkanen M, Hurley R, Doucette AM, Covino BG (1991) Treatment of acute systemic toxicity after the rapid intravenous injection of ropivacaine and bupivacaine in the conscious dog. Anesth Analg 73: 373–384
Feldman HS, Covino BM, Sage DJ (1982) Direct chronotropic and inotropic effects of local anesthetic agents in isolated guinea pig atria. Reg Anesth 7: 149–156
Fink BR (1989) Mechanisms of differential axial blockade in epidural and subarachnoid anesthesia. Anesthesiology 70: 851–858
Fink BR (1992) Toward the mathematization of spinal anesthesia. Reg Anesth 17: 263–273
Fink BR, Cairns AM (1983) Differential peripheral axon block with lidocaine: unit studies in the cervical vagus nerve. Anesthesiology 59: 182–186
Fink BR, Cairns AM (1984) Differential slowing and block of conduction by lidocaine in individual afferent myelinated and unmyelinated axons. Anesthesiology 60: 111–120
Fink BR, Cairns AM (1987) Lack of size-related differential sensitivity to equilibrium conduction block among mammalian myelinated axons exposed to lidocaine. Anesth Analg 66: 948–953
Fink BR, Cairns AM (1987) Differential use-depen-dent (frequency-dependent) effects in single mammalian axons: data and clinical considerations. Anesthesiology 67: 477–484
Foldes FF, Davidson GM, Duncalf D, Kuwabara S (1965) The intravenous toxicity of local anesthetic agents in man. Clin Pharmacol Ther 6: 328–335
Ford DJ, Raj PP, Pritam S, Regan KR, Ohlweiler D (1984) Differential peripheral nerve block by local anesthetics in the cat. Anesthesiology 60: 28–33
Franz DN, Perry RS (1974) Mechanisms for differential block among single myelinated and non-myelinated axons by procaine. J Physiol 236: 193–210
Frazier DT, Narahashi T, Yamada M (1970) The site of action and active form of local anesthetics. 2. Experiments with quaternary compounds. J Pharmacol Exp Ther 171: 45–51
Galindo A (1983) pH adjusted local anesthetics: clinical experience. Reg Anesth 8:35–36 (Abstract)
Galindo A, Witcher T (1980) Mixtures of local anesthetics: bupivacaine-chloroprocaine. Anesth Analg 59: 683–685
Gasser HS, Erlanger J (1929) The role of fiber size in the establishment of a nerve block by pressure or cocaine. Am J Physiol 88: 581–591
Gentiii F, Hudson AR, Hunter D, Kline DG (1980) Nerve injection injury with local anesthetic agents: a light and electron microscopic, fluorescent microscopic, and horseradish peroxidase study. Neurosurgery 6: 263–272
Gilly H, Kramer R, Zahorovsky I (1985) Lokalanaes-thetische Effekte von Morphin und Naloxon. Anaes-thesist 34: 619–626
Gissen AJ, Covino BG, Gregus J (1980) Differential sensitivities of mammalian nerve fibers to local anesthetic agents. Anesthesiology 53: 467–474
Gissen AJ, Covino BG, Gregus J (1982) Differential sensitivity of fast and slow fibers in mammalian nerve 3. Effect of etidocaine and bupivacaine on fast/slow fibers. Anesth Analg 61: 570–575
Gissen AJ, Covino BG, Gregus J (1982) Differential sensitivity of fast and slow fibers in mammalian nerve 2. Margin of safety for nerve transmission. Anesth Analg 61: 561–569
Gissen AJ, Datta S, Lambert D (1984) The chloropro-caine controversy II. Is chloroprocaine neurotoxic? Reg Anesth 9: 135–145
Gött U, Friess D (1985) Periduralanaesthesie mit Mepi-vacain-C02. Reg Anaesth 8: 50–53
Guinard JP, Carpenter RL, Owens BD, Nadir B (1991) Comparison between ropivacaine and bupivacaine after subcutaneous injection in pigs: cutaneous blood flow and surgical bleeding. Reg Anesth 16: 268–271
Hartrick CT, Dirkes WE, Coyle DE, Raj PP, Denson DD (1984) Influence of bupivacaine on mepivacaine protein binding. Clin Pharmacol Ther 36: 546–550
Hartrick CT, Raj PP, Dirkes WE, Denson DD (1984) Compounding of bupivacaine and mepivacaine for regional anesthesia: a safe practice? Ree Anesth 9: 94–97
Heath ML (1982) Deaths after intravenous regional anaesthesia. Br Med J 285: 913–914
Heath PJ, Brownlie GS, Herrick MJ (1990) Latency of brachial plexus block–The effect on onset time of warming local anaesthetic solutions. Anaesthesia 45: 297–301
Heavner JE (1986) Cardiac dysrhythmias induced by infusion of local anesthetics into the lateral cerebral ventricle of cats. Anesth Analg 65: 133–138
Heinbecker P, Bishop GH, O’Leary J (1934) Analysis of sensation in terms of the nerve impulse. Arch Neurol Psychiat 31: 34–53
Hendolin H, Mattila MAK (1988) Vergleich von Bupi-vacainhydrochlorid 0,5% und Bupivacaincarbonat 0,5% in der interscalenären Plexusanaesthesie. Reg Anaesth 11: 12–15
Hickey R, Candido KD, Ramamurthy S, Winnie AP, Blanchard J, Raza SM, Hoffman J, Durrani Z, Masters RW (1990) Brachial plexus block with a new local anaesthetic: 0.5 per cent ropivacaine. Can J Anaesth 37: 732–738
Hickey R, Hoffman J, Ramamurthy S (1991) A comparison of ropivacaine 0.5% and bupivacaine 0.5% for brachial plexus block. Anesthesiology 74: 639–642
Hilgier M (1985) Alkalinization of bupivacaine for brachial plexus block. Reg Anesth 8: 59–61
Hille B (1966) Common mode of action of three agents that decrease the transient change in sodium permeability in nerves. Nature (London) 210: 1220–1222
Hille B (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69: 497–515
Hille B, Courtney K, Dum R (1975) Rate and site of action of local anesthetics in myelinated nerve fibers. In: Fink BR (ed) Molecular mechanisms of anesthesia. Raven, New York, pp 13–20
Janik R, Erdmann K, Dick W (1987) Bupivacain-C02 und Bupivacain-HCl mit unterschiedlicher Injektionstemperatur zur Periduralanaesthesie bei extrakorporaler Stoßwellenlithotrypsie. Reg Anaesth 10: 82–87
Johns RA (1989) Local anesthetics inhibit endo-thelium-dependent vasodilation. Anesthesiology 70: 805–811
Johns RA, DiFazio CA, Longnecker DE (1985) Lidocaine constricts or dilates rat arterioles in a dose-dependent manner. Anesthesiology 62: 141–144
Johns RA, Seyde WC, DiFazio CA, Longnecker DE (1986) Dose-dependent effects of bupivacaine on rat muscle arterioles. Anesthesiology 65: 186–191
Jorfeldt L, Lewis DH, Löfström JB, Post C (1979) Lung uptake of lidocaine in healthy volunteers. Acta Anaesthesiol Scand 23: 567–574
Jorfeldt L, Löfström B, Pernow B, Persson B, Wahren J, Widman GB (1968) The effect of local anaesthetics on the central circulation and respiration in man and dog. Acta Anaesthesiol Scand 12: 153–169
Kalichmann MW (1993) Physiologic mechanisms by which local anesthetics may cause injury to nerve and spinal cord. Reg Anesth 18 [Suppl]: 448–452
Kaiichmann MW, Lalonde AW (1991) Experimental nerve ischemia and injury produced by cocaine and procaine. Brain Res 565: 34–41
Kaiichmann MW, Moorhouse DF, Powell HC, Myers RR (1993) Relative neural toxicity of local anesthetics. J Neuropathol Exp Neurol 52: 234–240
Kambam JR, Kinney WW, Matsuda F, Wright W, Holaday DA (1990) Epinephrine and phenylephrine increase cardiorespiratory toxicity of intravenously administered bupivacaine in rats. Anesth Analg 70: 543–545
Kane RE (1981) Neurologic deficits following epidural or spinal anesthesia. Anesth Analg 60: 150–161
Kasten GW, Martin ST (1986) Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse. Anesth Analg 65: 1029–1032
Katz JA, Bridenbaugh PO, Knarr DC, Helton SH, Denson DD (1990) Pharmacodynamics and pharmacokinetics of epidural ropivacaine in humas. Anesth Analg 70: 16–21
Katz JA, Knarr D, Bridenbaugh PO (1990) A double-blind comparison of 0.5% bupivacaine and 0.75% ropivacaine administered epidurally in humans. Reg Anesth 15: 250–252
Kendig JJ (1985) Clinical implications of the modulated receptor hypothesis: local anesthetics and the heart. Anesthesiology 62: 382–384
Kendig JJ, Cohen EN (1977) Pressure antagonism to nerve conduction block by anesthetic agents. Anesthesiology 47: 6–10
Kendig JJ, Grossman Y, Maclver MB (1988) Pressure reversal of anaesthesia: a synaptic mechanism. Br J Anaesth 60: 806–816
Kerkkamp HEM, Gielen MJM, Wattwil M, Axelsson KH, Dirkes W, Kehlet H, Edström HH (1990) An open study comparison of 0.5, 0.75 and 1.0% ropivacaine, with epinephrine, in epidural anesthesia in patients undergoing urologic surgery. Reg Anesth 15: 53–58
Knapp DE (1968) Tolerance development to a local anesthetic effect of meperidine. J Oral Ther Pharmacol 4: 364–368
Knoche E, Traub E, Dick W (1979) Bupivacain-HCl und Bupivacain-CO2. Vergleichende Untersuchungen während der kontinuierlichen Periduralanaesthesie in der Geburtshilfe. Reg Anaesth 2: 36–42
Koch T, Mathieu K, Lanz E, Theiss D (1984) Periduralanaesthesie mit Etidocain–Klinische Untersuchungen zum Einfluß von Vasokonstriktoren auf die sensible und motorische Blockade. Reg Anaesth 7: 39–43
Komai H, Rusy BF (1981) Effects of bupivacaine and lidocaine on AV conduction in the isolated rat heart: modification by hyperkalemia. Anesthesiology 55: 281–285
Kopacz DJ, Carpenter RL, Mackey DC (1989) Effect of ropivacaine on cutaneous capillary blood flow in pigs. Anesthesiology 71: 69–74
Kotelko DM, Shnider SM, Dailey PA, Brizgys RV, Levinson G, Shapiro WA, Koike M, Rosen MA (1984) Bupivacaine-induced cardiac arrhythmias in sheep. Anesthesiology 60: 10–18
Lalka D, Vicuna N, Burrow SR, Jones DJ, Ludden TM, Haegele KD, McNay JL (1978) Bupivacaine and other amide local anesthetics inhibit the hydrolysis of chlo-roprocaine by human serum. Anesth Analg 57: 534–539
Lambert DH, Hurley RJ (1991) Cauda equina syndrome and continuous spinal anesthesia. Anesth Analg 72: 817–819
Lambert DH, Möllmann M (1993) Continuous spinal anesthesia. In: van Aken H (ed) Bailliere’s clinical anaesthesiology–New developments in epidural and spinal drugs administration. Bailliere Tindall, London, pp 709–726
Lambert LA, Lambert DH, Strichartz GR (1994) Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. Anesthesiology 80: 1082–1093
Lee A, Fagan D, Lamont M, Tucker GT, Halldin M, Scott DB (1989) Disposition kinetics of ropivacaine in humans. Anesth Analg 69: 736–738
Lee-Son S, Wang GK, Concus A, Crill E, Strichartz GR (1992) Stereoselective inhibition of neuronal sodium channels by local anesthetics–Evidence for two sites of action? Anesthesiology 77: 324–335
Leicht CH, Carlson SA (1986) Prolongation of lidocaine spinal anesthesia with epinephrine and phenylephrine. Anesth Analg 65: 365–369
Lipfert P (1989) Wirkungen und Nachwirkungen pharmakologisch induzierter Leitungsblockaden auf Funktion und Struktur von Warmblüternerven. Habilitationsschrift, Heinrich-Heine-Universität Düsseldorf, S 1–109
Lipfert P, Seitz RJ, Arndt JO (1987) Studies of local anesthetic action on natural spike activity in the aortic nerve of cats. Anesthesiology 66: 210–213
Lipfert P, Seitz RJ, Arndt JO (1987) Ultralong-lasting nerve block: triethyldodecyl ammonium bromide is probably a neurotoxin rather than a local anesthetic. Anesthesiology 67: 896–904
Littlewood DG, Buckley P, Covino BG, Scott DB, Wilson J (1979) Comparative study of various local anaesthetic solutions in extradural block in labour. Br J Anaesth 51: 47S - 51S
Liu P, Feldman HS, Covino BM, Giasi R, Covino BG (1982) Acute cardiovascular toxicity of intravenous amide local anesthetics in anesthetized ventilated dogs. Anesth Analg 61: 317–322
Liu PH, Feldman HS, Giasi R, Patterson K, Covino BG (1983) Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. Anesth Analg 62: 375–37
Löfstrom JB (1975) Ulnar nerve blockade for the evaluation of local anaesthetic agents. Br J Anaesth 47: 297–300
Löfström JB (1978) Tissue distribution of local anesthetics with special reference to the lung. Int Anesthesiol Clin 16: 53–71
Long WB, Rosenblum S, Grady IP (1989) Successful resuscitation of bupivacaine-induced cardiac arrest using cardiopulmonary bypass. Anesth Analg 69: 403–406
Luduena FP, Bogado EF, Tullar BF (1972) Optical isomers of mepivacaine and bupivacaine. Arch Int Phar-macodyn 200: 359–369
Lund PC (1962) Peridural anesthesia. Acta Anaesthesiol Scand 6: 143–159
Lund PC, Cwik JC (1966) A correlation of the differential penetration and the systemic toxicity of lidocaine, mepivacaine and prilocaine in man. Acta Anaesthesiol Scand 23 [Suppl]: 475–482
Lund PC, Cwik JC, Gannon RT (1974) Etidocaine (Duranest): a clinical and laboratory evaluation. Acta Anaesthesiol Scand 18: 176–188
Lynch C (1986) Depression of myocardial contractility in vitro by bupivacaine, etidocaine, and lidocaine. Anesth Analg 65: 551–559
Mallampati SR, Liu PL, Knapp RM (1984) Convulsions and ventricular tachycardia from bupivacaine with epinephrine: successful resuscitation. Anesth Analg 63: 856–859
Martin R, Lamarche Y, Tetreault L (1981) Comparison of the clinical effectiveness of lidocaine hydrocarbo-nate and lidocaine hydrochloride with and without epinephrine in epidural anaesthesia. Can Anaesth Soc J 28: 217–223
Mather LE (1991) Disposition of mepivacaine and bupivacaine enantiomers in sheep. Br J Anaesth 67: 239–246
Mather LE, Rutten AJ (1991) Stereochemistry and its relevance in anaesthesiology. Curr Opinion Anaesth 4: 473–479
Mather LE, Tucker GT, Murphy TM, Stanton-Hicks M, Bonica JJ (1976) The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia. II: pharmacokinetics. Br J Anaesth 48: 989–994
McClure JH, Scott DB (1981) Comparison of bupivacaine hydrochloride and carbonated bupivacaine in brachial plexus block by the interscalene technique. Br J Anaesth 53: 523–526
McEllistrem RF, Bennington RG, Roth SH (1993) In vitro determination of human dura mater permeability to opioids and local anaesthetics. Can J Anaesth 40: 165–169
McMorland GH, Douglas MJ, Jeffery WK, Ross PLE, Axelson JE, Kim JHK, Gambling DR, Roberston K (1986) Effect of pH-adjustment of bupivacaine on onset and duration of epidural analgesia in parturients. Can Anaesth Soc J 33: 537–541
Mehta PM, Theriot E, Mehrotra D, Patel K, Kimball BG (1987) A simple technique to make bupivacaine a rapid-acting epidural anesthetic. Reg Anesth 12: 135–138
Meyer J, Heinemann H (1985) Temperaturabhängige Wirkungen von Lidocain-C02 in der Periduralanaes-thesie. Reg Anaesth 8: 5–7
Michenfelder JD, Steen PA (1979) Neural toxicity of local and general anesthetics. In: Vinken PJ, Bruyn GW (eds) Handbook of clinial neurology 36. North Holland, Amsterdam, pp 401–416
Moir DD, Slater PJ, Thorburn J, McLaren R, Moodie J (1976) Extradural analgesia in obstetrics: a controlled trial of carbonated lignocaine and bupivacaine hydrochloride with or without adrenaline. Br J Anaesth 48: 129–135
Moller R, Covino BG (1990) Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic. Anesthesiology 72: 322–329
Moller RA, Covino BG (1988) Cardiac electrophysiologic effects of lidocaine and bupivacaine. Anesth Analg 67: 107–114
Moller RA, Covino BG (1992) Effects of progesterone on the cardiac electrophysiologic alterations produced by ropivacaine and bupivacaine. Anesthesiology 77: 735–741
Moller RA, Datta S, Fox J, Johnson M, Covino BG (1992) Effects of progesterone on the cardiac electrophysiologic action of bupivacaine and lidocaine. Anesthesiology 76: 604–608
Moore DC (1980) Spinal anesthesia: bupivacaine compared with tetracaine. Anesth Analg 59: 743–750
Moore DC, Bridenbaugh LD (1966) Spinal (subarachnoid) block–A review of 11574 cases. JAMA 195: 907–912
Moore DC, Bridenbaugh LD, Thompson GE, Balfour RI, Horton WG (1978) Bupivacaine: a review of 11080 cases. Anesth Analg 57: 42–53
Moore DC, Spierdijk J, van Kleef JD, Coleman RL, Love GF (1982) Chloroprocaine neurotoxicity: four additional cases. Anesth Analg 61: 155–159
Moore RA, Bullingham RES, McQuay HJ, Hand CW, Aspel JB, Allen MC, Thomas D (1982) Dural permeability to narcotics: in vitro determination and application to extradural administration. Br J Anaesth 54: 1117–1128
Morishima HO, Pedersen H, Finster M, Hiraoka H, Tsuji A, Feldman HS, Arthur GR, Covino BG (1985) Bupivacaine toxicity in pregnant and nonpregnant ewes. Anesthesiology 63: 134–139
Morishima HO, Pedersen H, Finster M, Sakuma K, Bruce SL, Gutsche BB, Stark RI, Covino BG (1981) Toxicity of lidocaine in adult, newborn, and fetal sheep. Anesthesiology 55: 57–61
Morison DH (1981) A double-blind comparison of carbonated lidocaine and lidocaine hydrochloride in epidural anaesthesia. Can Anaesth Soc J 28: 387–389
Murphy TM, Mather LE, Stanton-Hicks M, Bonica JJ, Tucker GT (1976) The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia I: block characteristics and cardiovascular effects. Br J Anaesth 48: 893–898
Myers RR, Heckman HM (1989) Effects of local anesthesia on nerve blood flow: studies using lidocaine with and without epinephrine. Anesthesiology 71: 757–762
Myers RR, Kalichman NW, Reisner LS, Powell HC (1986) Neurotoxicity of local anesthetics: altered peri-neurial permeability, edema, and nerve fiber injury. Anesthesiology 64: 29–35
N.N (1985) Lokalanaesthetika: Bei Anwendung in der Praxis beachten–Information der Arzneimittelkommission der Deutschen Ärzteschaft. Dtsch Ärztebl 82: 100–101
N.N (1986) Cardiotoxicity of local anaesthetic drugs. Lancet 11: 1192–1194
Nakamura K, Toda H, Kakuyama M, Nishiwada M, Yamamoto M, Hatano Y, Mori K (1993) Direct vascular effect of ropivacaine in femoral artery and vein of the dog. Acta Anaesthesiol Scand 37: 269–273
Nancarrow C, Runciman WB, Mather LE, Upton RN, Plummer JL (1987) The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep. Anesth Analg 66: 925–935
Nancarrow C, Rutten AJ, Runciman WB, Mather LE, Carapetis RJ, McLean CF, Hipkins SF (1989) Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep. Anesth Analg 69: 276–283
Narahashi T, Frazier DT, Yamada M (1970) The site of action and active form of local anesthetics. 1. Theory and pH experiments with tertiary compounds. J Pharmacol Exp Ther 171: 32–44
Nath S, Häggmark S, Johansson G, Reiz S (1986) Differential depressant and electrophysiological cardioto-xicity of local anesthetics: an experimental study with special reference to lidocaine and bupivacaine. Anesth Analg 65: 1263–1270
Nathan PW, Sears TA (1960) Effects of phenol on nervous conduction. J Physiol 150: 565–580
Nathan PW, Sears TA, Smith MC (1965) Effects of phenol solutions on the nerve roots of the cat: an electrophysiological and histological study. J Neurol Sei 2: 7–29
Nickel PM, Bromage PR, Sherrill DL (1986) Comparison of hydrochloride and carbonated salts of lidocaine for epidural analgesia. Reg Anesth 11: 62–67
Niesei HC, Eilingsfeld T, Kaiser H, Klimpel L (1990) Ropivacain zur Periduralanaesthesie–Untersuchungen zur Dosis-Wirkungsrelation bei orthopädischen Eingriffen. Reg Anaesth 13: 73–77
Niesei HC, Kaiser H (1991) Grenzdosis fur Lokal-anaesthetika–Empfehlungen nach toxikologischen und pharmakokinetischen Daten. Reg Anaesth 14: 79–82
Niesei HC, Kaiser H, Eilingsfeld T (1990) Ropivacain–ein neues Lokalanaesthetikum mit spezifischen Eigenschaften. Reg Anaesth 13: 54–56
Nolte H (1986) Quo vadis: Bupivacain 0,75%. Reg Anaesth 9: 1–3
Nolte H (1986) Zur Problematik der Cardiotoxizität von Bupivacain 0,75%. Reg Anaesth 9: 57–59
Nolte H, Fruhstorfer H, Edström HH (1990) Local anesthetic efficacy of ropivacaine (LEA 103) in ulnar nerve block. Reg Anesth 15: 118–124
Nolte H, Puente-Egido J J, Dudeck J, Niemer M (1967) Wirkungsverlängerung der Lokalanaesthesie durch Dextran 6%. Anaesthesist 16: 221–224
Palmer SK, Bosnjak ZJ, Hopp FA, von Colditz JH, Kampine JP (1983) Lidocaine and bupivacaine differential blockade of isolated canine nerves. Anesth Analg 62: 754–757
Pitkanen M, Feldman HS, Arthur GR, Covino BG (1992) Chronotropic and inotropic effects of ropivacaine, bupivacaine, and lidocaine in the spontaneously beating and electrically paced isolated, perfused rabbit heart. Reg Anesth 17: 183–192
Poppers PJ, Katz RL, Ericson EY Meyer MB, Covino BG (1974) Evaluation of etidocaine, a new local anesthetic agent, with a modified bilateral ulnar-nerve-block technique. Anesthesiology 40: 1 3–18
Post C, Eriksdotter-Behm K (1982) Dependence of lung uptake of lidocaine in vivo on blood pH. Acta Pharmacol Toxicol 51: 136–140
Quinlan JJ, Oleksey K, Murphy FL (1992) Alkaliniza-tion of mepivacaine for axillary block. Anesth Analg 74: 371–374
Racle JP, Benkhadra A, Poy JY, Gleizal B (1987) Prolongation of isobaric bupivacaine spinal anesthesia with epinephrine and Clonidine for hip surgery in the elderly. Anesth Analg 66: 442–446
Racle JP, Benkhadra A, Poy JY, Gleizal B (1987) Effect of increasing amounts of epinephrine during isobaric bupivacaine spinal anesthesia in elderly patients. Anesth Analg 66: 882–886
Raj PP, Rosenblatt R, Miller J, Katz RL, Carden E (1977) Dynamics of local-anesthetic compounds in regional anesthesia. Anesth Analg 56: 110–117
Ravindran RS, Bond VK, Tasch MD, Gupta CD, Luer-seen TG (1980) Prolonged neural blockade following regional analgesia with 2-chloroprocaine. Anesth Analg 59: 447–451
Ravindran RS, Turner MS, Muller I (1982) Neurologic effects of subarachnoid administration of 2-chloropro-caine-CE, bupivacaine, and low pH normal saline in dogs. Anesth Analg 61: 279–283
Raymond SA, Steffensen SC, Gugino LD, Strichartz GR (1989) The role of length of nerve exposed to local anesthetics in impulse blocking action. Anesth Analg 68: 563–570
Ready LB, Plumer MH, Haschke RH, Austin E, Sumi SM (1985) Neurotoxicity of intrathecal local anesthetics in rabbits. Anesthesiology 63: 364–370
Reisner LS, Hochman BN, Plumer MH (1980) Persistent neurologic deficit and adhesive arachnoiditis following intrathecal 2-chloroprocaine injection. Anesth Analg 59: 452–454
Reiz S, Häggmark S, Johansson G, Nath S (1989) Cardiotoxicity of ropivacaine–a new amide local anaesthetic agent. Acta Anaesthesiol Scand 33: 93–98
Reiz S, Nath S (1986) Cardiotoxicity of local anaesthetic agents. Br J Anaesth 58: 736–746
Renck H, Edström HH, Kinnberger B, Brandt G (1976) Thoracic epidural analgesia–II: Prolongation in the early postoperative period by continuous injection of 1.0% bupivacaine. Acta Anaesthesiol Scand 20: 47–56
Reynolds F (1987) Adverse effects of local anaesthetics. Br J Anaesth 59: 78–95
Richter O, Klein K, Abel J, Ohnesorge FK, Wüst HJ, Thiessen F (1984) The kinetics of bupivacaine plasma concentrations during epidural anesthesia following intraoperative bolus injection and subsequent continuous infusion. Int J Clin Pharmacol Ther Toxicol 22: 611–617
Rieselbach RE, Di Chiro G, Freireich EJ, Rail DP (1962) Subarachnoid distribution of drugs after lumbar injection. N Engl J Med 267: 1273–1278
Rigler ML, Drasner K (1991) Distribution of catheter-injected local anesthetic in a model of the subarachnoid space. Anesthesiology 75: 684–692
Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J, Bohner D (1991) Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg 72: 275–281
Ritchie JM (1975) Mechanism of action of local anaesthetic agents and biotoxins. Br J Anaesth 47: 191–198
Ritchie JM, Ritchie B, Greengard P (1965) The active structure of local anesthetics. J Pharmacol Exp Ther 150: 152–159
Ritchie JM, Ritchie B, Greengard P (1965) The effect of the nerve sheath on the action of local anesthetics. J Pharmacol Exp Ther 150: 160–164
Ritchie JM, Ritchie BR (1968) Local anesthetics: effect of pH on activity. Science 162: 1394–1395
Rosen MA, Thigpen JW, Shnider SM, Foutz SE, Levin-son G, Koike M (1985) Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep. Anesth Analg 64: 1089–1096
Rosenberg PH, Heavner JE (1980) Temperature-depen-dent nerve-blocking action of lidocaine and halothane. Acta Anaesthesiol Scand 24: 314–320
Rosenberg PH, Heinonen E (1983) Differential sensitivity of A and C nerve fibres to long-acting amide local anaesthetics. Br J Anaesth 55: 163–167
Rosenberg PH, Kyttä J, Alila A (1986) Absorption of bupivacaine, etidocaine, lignocaine and ropivacaine into n-heptane, rat sciatic nerve, and human extradural and subcutaneous fat. Br J Anaesth 58: 310–314
Ross RA, Clarke JE, Armitage EN (1980) Postoperative pain prevention by continuous epidural infusion. Anaesthesia 35: 663–668
Routledge PA, Barchowsky A, Bjornsson TD, Kitchell BB, Shand DG (1980) Lidocaine plasma protein binding. Clin Pharmacol Ther 27: 347–351
Rowlingson JC (1993) Toxicity of local anesthetic additives. Reg Anesth 18 (Suppl): 435–460
Rud J (1961) Local anesthetics–an electrophysiological investigation of local anesthesia of peripheral nerves, with special reference to Xylocaine. Acta Physiol Scand 51 (Suppl 178): 1–171
Rutten AJ, Mather LE, McLean CF (1991) Cardiovascular effects and regional clearances of i. v. bupivacaine in sheep: enantiomeric analysis. Br J Anaesth 67: 247–256
Sage DJ, Feldman HS, Arthur GR, Datta S, Ferretti AM, Norway SB, Covino BG (1984) Influence of lidocaine and bupivacaine on isolated guinea pig atria in the presence of acidosis and hypoxia. Anesth Analg 63: 1–7
Santos AC, Pedersen H, Sallusto JA, Johnson HV, Morishima HO, Finster M, Arthur GR, Covino BG (1990) Pharmacokinetics of ropivacaine in nonpregnant and pregnant ewes. Anesth Analg 70: 262–266
Savarese JJ, Covino BG (1986) Basic and clinical pharmacology of local anesthetic drugs. In: Miller RD (ed) Anesthesia. Churchill Livingstone, New York, pp 986–1013
Schell RM, Brauer FS, Cole DJ, Applegate RL (1991) Persistent sacral nerve root deficits after continuous spinal anaesthesia. Can J Anaesth 38: 908–911
Schulte-Steinberg O, Hartmuth J, Schütt L (1970) Carbon dioxide salts of lignocaine in brachial plexus block. Anaesthesia 25: 191–197
Schwarz W, Palade PT, Hille B (1977) Local anesthetics–effect of pH on use-dependent block of sodium channels in frog muscle. Biophys J 20: 343–368
Scott DB (1975) Evaluation of clinical tolerance of local anaesthetic agents. Br J Anaesth 47: 328–333
Scott DB (1975) Evaluation of the toxicity of local anaesthetic agents in man. Br J Anaesth 47: 56–61
Scott DB (1986) Toxic effects of local anaesthetic agents on the central nervous system. Br J Anaesth 58: 732–735
Scott DB, Jebson PJR, Braid DP, Oertengren B, Frisch P (1972) Factors affecting plasma levels of lignocaine and prilocaine. Br J Anaesth 44: 1040–1049
Scott DB, Lee A, Fagan D, Bowler GMR, Bloomfield P, Lundh R (1989) Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 69: 563–569
Scott DB, McClure JH, Giasi RM, Seo J, Covino BG (1980) Effects of concentration of local anaesthetic drugs in extradural block. Br J Anaesth 52: 1033–1037
Seeman P (1972) The membrane actions of anesthetics and tranquilizers. Pharmacol Rev 24: 583–655
Seeman P (1977) Anesthetics and pressure reversal of anesthesia: expansion and recompression of membrane proteins, lipids, and water. Anesthesiology 47: 1–3
Seitz RJ, Lipfert P, Willrich A, Himmelmann F (1989) Toxic effects of triethyldodecylammoniumbromide (TEA-C12) on myelinated nerve fibers and blood-nerve barrier in the mouse. Exp Brain Res 74: 293–302
Seiander D (1993) Neurotoxicity of local anesthetics: animal data. Reg Anesth 18 (Suppl): 461–468
Seiander D, Brattsand R, Lundborg G, Nordborg C, Olsson Y (1979) Local anesthetics: importance of mode of application, concentration and adrenaline for the appearance of nerve lesions. Acta Anaesthesiol Scand 23: 127–136
Smith S, Ramamurthy S, Walsh N (1986) Effect of sodium bicarbonate on the onset of blockade by bupivacaine. Reg Anesth 11: 48 (Abstract)
Spivey DL (1985) Epinephrine does not prolong lidocaine spinal anesthesia in term parturients. Anesth Analg 64: 468–470
Steen PA, Michenfelder JD (1979) Neurotoxicity of anesthetics. Anesthesiology 50: 437–453
Stienstra R, Greene NM (1991) Factors affecting the subarachnoid spread of local anesthetic solutions. Reg Anesth 16: 1–6
Strichartz GR (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J Gen Physiol 62: 37–57
Strichartz GR (1988) Neural physiology and local anesthetic action. In: Cousins MJ, Bridenbaugh PO (eds) Neural blockade in clinical anesthesia and management of pain. Lippincott, Philadelphia, pp 25–45
Strichartz GR, Ritchie JM (1987) The action of local anesthetics on ion channels of excitable tissues. In: Strichartz GR (ed) Local anesthetics. Springer, Berlin Heidelberg New York, pp 21–52
Sukhani R, Winnie AP (1987) Clinical pharmacokinetics of carbonated local anesthetics I: Subclavian perivascular block model. Anesth Analg 66: 739–745
Sukhani R, Winnie AP (1987) Clinical pharmacokinetics of carbonated local anesthetics II: Interscalene brachial block model. Anesth Analg 66: 1245–1250
Tanz RD, Heskett T, Loehning RW, Fairfax CA (1984) Comparative cardiotoxicity of bupivacaine and lidocaine in the isolated perfused mammalian heart. Anesth Analg 63: 549–556
Tasaki I (1953) Transmission in the narcotized fiber. In: Tasaki I (ed) Nervous transmission. Thomas, Springfield, pp 90–106
Thomas RD, Behbehani MM, Coyle DE, Denson DD (1986) Cardiovascular toxicity of local anesthetics: an alternative hypothesis. Anesth Analg 65: 444–450
Tryba M, Börner P (1988) Klinische Wirksamkeit und Systemtoxizität verschiedener Mischungen von Prilo-cain und Bupivacain zur axillären Plexusblockade. Reg Anaesth 11: 40–49
Tucker GT (1986) Pharmacokinetics of local anaesthetics. Br J Anaesth 58: 717–731
Tucker GT (1990) Local anaesthetic drugs–mode of action and pharmacokinetics. In: Nimmo WS, Smith G (eds) Anaesthesia. Blackwell, Oxford, pp 983–1010
Tucker GT (1994) Safety in numbers–The role of pharmacokinetics in local anesthetic toxicity. Reg Anesth 19: 155–163
Tucker GT, Boas RA (1971) Pharmacokinetic aspects of intravenous regional anesthesia. Anesthesiology 34: 538–549
Tucker GT, Mather LE (1975) Pharmacology of local anaesthetic agents–Pharmacokinetics of local anaesthetic agents. Br J Anaesth 47: 213–224
Tucker GT, Mather LE (1988) Properties, absorption, and disposition of local anesthetic agents. In: Cousins MJ, Bridenbaugh PO (eds) Neural blockade in clinical anesthesia and management of pain. Lippincott, Philadelphia, pp 47–110
Tucker GT, Mather LE, Lennard MS, Gregory A (1990) Plasma concentrations of the stereoisomers of prilocaine after administration of the racemate: implications for toxicity? Br J Anaesth 65: 333–336
Tucker GT, Moore DC, Bridenbaugh PO, Bridenbaugh LD, Thompson GE (1972) Systemic absorption of mepivacaine in commonly used regional block procedures. Anesthesiology 37: 277–287
Veering BT, Burm AGL (1993) Pharmacokinetics and pharmacodynamics of medullar agents–Local anaesthetics. In: van Aken H (ed) Bailliere’s clinical anaesthesiology–New developments in epidural and spinal drugs administration. Bailiiere Tindall, London, pp 557–577
Vree TB, Beumer EMC, Lagerwerf AJ, Simon MAM, Gielen MJM (1992) Clinical pharmacokinetics of R(+)- and S(-)-mepivacaine after high doses of racemic mepivacaine with epinephrine in the combined psoas compartment/sciatic nerve block. Anesth Analg 75: 75–80
Wahedi W, Nolte H, Trombitas G, Wehking M (1990) Zur Frage der Äquipotenz von Ropivacain, Bupivacain und Etidocain. Reg Anaesth 13: 66–72
Wahedi W, Nolte H, Witte P (1990) Ropivacain zur Epiduralanaesthesie–Dosis-Wirkungsrelation und Vergleich mit Bupivacain. Reg Anaesth 13: 57–65
Wang BC, Hillman DE, Spielholz NI, Turndorf H (1984) Chronic neurological deficits and nesacaine-CE–an effect of the anesthetic, 2-chloroprocaine, or the antioxidant, sodium bisulfite? Anesth Analg 63: 445–447
Weindler M, Koßmann B, Dick W, Mehrkens HH, Seeling W, Schwabe K (1984) Katheterperidural-anaesthesie mit Bupivacain-HCl und Bupivacain-CO2. Reg Anaesth 7: 125–130
Wheeler DM, Bradley EL, Woods WT (1988) The electrophysiologic actions of lidocaine and bupivacaine in the isolated, perfused canine heart. Anesthesiology 68: 201–212
Whitehead E, Arrigoni B, Bannister J (1990) An open study of ropivacaine in extradural anaesthesia. Br J Anaesth 64: 67–71
Wiklund L, Berlin-Wahlen A (1977) Splanchnic elimination and systemic toxicity of bupivacaine and etidocaine in man. Acta Anaesthesiol Scand 21: 521–528
Wildsmith JAW, Brown DT, Paul D, Johnson S (1989) Structure-activity relationships in differential nerve block at high and low frequency stimulation. Br J Anaesth 63: 444–452
Wildsmith JAW, Gissen AJ, Takman B, Covino BG (1987) Differential nerve blockade: esters vs. amides and the influence of pKa. Br J Anaesth 59: 379–384
Wildsmith JAW, Tucker GT, Cooper S, Scott DB, Covino BG (1977) Plasma concentrations of local anaesthetics after interscalene brachial plexus block. Br J Anaesth 49: 461–466
Wilkinson GR, Lund PC (1970) Bupivacaine levels in plasma and cerebrospinal fluid following peridural administration. Anesthesiology 33: 482–486
Willdeck-Lund G, Edström HH (1975) Etidocaine in intercostal nerve block for pain relief after thoracotomy–a comparison with bupivacaine. Acta Anaesthesiol Scand 60 (Suppl): 33–38
Wong K, Strichartz GR, Raymond SA (1993) On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve. Anesth Analg 76: 131–143
Wood M (1990) Local anesthetic agents. In: Wood M, Wood AJJ (eds) Drugs and anesthesia–Pharmacology for anesthesiologists. Williams & Wilkins, Baltimore, pp 319–35
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Lipfert, P. (1995). Pharmakologie von Lokalanästhetika. In: Doenicke, A., Kettler, D., List, W.F., Radke, J., Tarnow, J. (eds) Anästhesiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97553-0_8
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