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Hepatocellular Carcinoma, Liver, Rat

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Digestive System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Hepatocellular carcinomas are usually visible grossly and range in size from several millimeters to several centimeters (Färber 1976; Greenblatt and Lijinsky 1972) (Fig. 29). They are roughly spherical, although multilobulation may distort the shape (Fig. 30), and appear as single or multiple light-tan to dark-red lesions in the liver. Rats chronically exposed to potent hepatocarcinogens frequently have multiple hepatocellular carcinomas alone or in combination with neoplastic nodules (Fig. 29). The liver of such an animal may be almost totally replaced by numerous, variably sized neoplastic and preneoplastic lesions.

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Authors
  1. James A. Popp
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Editors and Affiliations

  1. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) & Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology, Emeritus) &  (Professor of Comparative Pathology)

  2. Institut fĂĽr Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M. D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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© 1985 Springer-Verlag Berlin Heidelberg

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Popp, J.A. (1985). Hepatocellular Carcinoma, Liver, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96910-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-96910-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96912-6

  • Online ISBN: 978-3-642-96910-2

  • eBook Packages: Springer Book Archive

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