Abstract
Of all the developmental brain disorders, autism is perhaps the most fascinating, the most mysterious, and the most telling fascinating, because of its impact on absolutely every aspect of a child’s perception of and interaction with the surrounding world; mysterious, because of the complexity of the many interacting brain systems it perturbs; telling, because it strikes at the social, cognitive, and linguistic abilities that seem, at least on the surface, so essential to one’s very humanity. During the past few decades, the riddle of autism has begun to yield to advances in the study of autistic behaviour and the biological foundations which affect it. The examination of brain anatomy, physiology, histology and function in people with autism continues to supply new information on the nature and aetiology of this complex syndrome. This chapter will focus primarily on the neuroanatomical and neurophysiological abnormalities found in autistic subjects, particularly those seen in magnetic resonance imaging (MRI) and event-related potential (ERP) studies.
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References
Adrien JL, Perrot A, Sauvage D, Leddet E, Larmande C, Hameury L, Barthélémy C (1992) Early symptoms in autism from family home movies. Evaluation and comparison between ist and 2nd year of life using I.B.S.E. scale. Acta Pædopsychiatrica 55 2: 71–75
Akshoomoff NA, Courchesne E (1992) A new role for the cerebellum in cognitive operations. Behav Neurosci 106 5: 731–738
Akshoomoff NA, Courchesne E (1994) ERP evidence for a shifting attention deficit in patients with damage to the cerebellum. J Cogn Neurosci 6 4: 388–399
Allen G, Buxton RB, Wong EC, Courchesne E (submitted) Attention activates the cerebellum independently of motor involvement American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edition. American Psychiatric Association, Washington, DC
Attig E, Botez MI, Hublet C, Vervonck C, Jacquy J, Capon A (1991) Diaschisis cérébral croisé par lésion cérébel-leuse: Röle du cervelet dans les fonctions mentales. Rev Neurol 147 3: 200–207
Bachevalier J (1994) Medial temporal lobe structures and autism: A review of clinical and experimental findings. Neuropsychologia 32 6: 627–648
Baron-Cohen S (1989) The autistic child’s theory of mind: A case of specific developmental delay. J Child Psychol Psychiat 30 2: 285–297
Baron-Cohen S, Ring H, Moriarty J, Schmitz B, Costa D, Ell P (1994) Recognition of Mental State Terms. Clinical findings in children with autism and a functional neuroimaging study of normal adults. British J Psychiat 165 5: 640–649
Bauman ML (1991) Microscopic neuroanatomic abnormalities in autism. Pediatrics 87 5: 791–796
Bauman ML, Kemper TL (1985) Histoanatomic observations of the brain in early infantile autism. Neurology 35 6: 866–874
Bauman ML, Kemper TL (1993) The Contribution of Neu-ropathologic Studies to the Understanding of Autism. Neurol Clinics 11 1: 175–187
Belmonte M (1997a) Shifts of Visual Spatial Attention Modulate a Steady-State Visual Evoked Potential. In preparation
Belmonte M (1997b) A Software System for Analysis of Steady-State Evoked Potentials. In preparation
Belmonte M (1997c) Abnormal Spatial Attention in Autism Demonstrated by Lack of Modulation of a Steady-State Visual Evoked Potential. In preparation
Belmonte M, Egaas B, Townsend J, Courchesne E (1995) NMR intensity of corpus callosum differs with age but not with diagnosis of autism. NeuroReport 6 9: 1253–1256
Bryson SE, Wainwright-Sharp JA, Smith IM (1990) Autism: A developmental spatial neglect syndrome? In: Enns JT (ed) The development of attention: Research and theory. Elsevier, Amsterdam, p 405
Casey BJ, Gordon CT, Mannheim GB, Rumsey JM (1993) Dysfunctional attention in autistic savants. J Clin Exp Neuropsychol 15 6: 933–946
Cook EH (1990) Autism: Review of neurochemical investigation. Synapse 6 3: 292–308
Cook EH, Charak DA, Arida J, Spohn JA, Roizen NJ, Leventhal BL (1994) Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder. Psychiat Res 52 1: 25–33
Ciesielski KT, Courchesne E, Elmasian R (1990) Effects of focused selective attention tasks on event-related potentials in autistic and normal individuals. Electroencepha-logr Clin Neurophysiol 075 3: 207–220[erratum in 766: 566 (1990)]
Comings DE, Comings BG, Muhleman D, Dietz G, Shahbahrami B, Tast D, Knell E, Kocsis P, Baumgarten R, Kovacs BW, Levy DL, Smith M, Borison RL, Evans DD, Klein DN, MacMurray J, Tosk JM, Sverd J, Gysin R, Flanagan SD (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric isorders. J Am Med Ass 266 13: 1793–1800
Courchesne E, Hesselink JR, Jernigan TL, Yeung-Cour-chesne R (1987) Abnormal neuroanatomy in a non-retarded person with autism. Unusual Findings with Magnetic Resonance Imaging. Arch Neurol 44 3: 335–341
Courchesne E, Kilman B, Galambos R, Lincoln A (1984) Autism: processing of novel auditory information assessed by event-related brain potentials. Electroence-phalogr Clin Neurophysiol 59 3: 238–248
Courchesne E, Lincoln A, Kilman B, Galambos R (1985) Event-related brain potential correlates of the processing of novel visual and auditory information in autism. J Autism Dev Disord 15 1: 55–76
Courchesne E, Lincoln A, Yeung-Courchesne R, Elmasian R, Grillon C (1989) Pathophysiologic findings in non-retarded autism and receptive developmental language disorder. J Autism Dev Disord 19 1: 1–17
Courchesne E, Press G, Yeung-Courchesne R (1993) Parietal lobe abnormalities detected with MR in patients with infantile autism. Am J Roentgenol 160 2: 387–393
Courchesne E, Saitoh O, Yeung-Courchesne R, Press G, Lincoln A, Haas R, Schreibman L (1994) Abnormality of cerebellar vermian lobules VI and VII in patients with infantile autism: Identification of hypoplastic and hyperplastic subgroups with MR imaging. Am J Roentgenol 162 1: 123–30
Courchesne E, Townsend J, Saitoh O (1994) The brain in infantile autism: Posterior fossa structures are abnormal. Neurology 44 2: 214–223
Courchesne E, Yeung-Courchesne R, Press G, Hesselink JR, Jernigan TL (1988) Hypoplasia of cerebellar vermal lobules VI and VII in autism, N Engl J Med 318 21:1349–1354
Crepel F (1982) Regression of functional synapses in the immature mammalian cerebellum. Trends Neurosci 5: 266–269
Crispino L, Bullock TH (1984) Cerebellum mediates modality-specific modulation of sensory responses of the midbrain and forebrain in rat. Proc Nat Acad Sei 81 9: 2917–2920
Damasio A, Maurer R (1978) A neurological model for childhood autism. Arch Neurol 35 12: 777–786
Daniels WW, Warren RP, Odell JD, Maciulis A, Burger RA, Warren WL, Torres AR (1995) Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in autism. Neuropsychobiology 32 3: 120–123
Davila-Garcia MI, Azmitia EC (1989) Effects of acute and chronic administration of leu-enkephalin on cultured serotonergic neurons: Evidence for opioids as inhibitory neuronal growth factors. Dev Brain Res 49 1: 97–103
DeLong GR, Bean SC, Brown FR (1981) Acquired reversible autistic syndrome in acute encephalopathic illness in children. Arch Neurol 38 3: 191–194
DeLong GR, Nohria C (1994) Psychiatric family history and neurological disease in autistic spectrum disorders. Dev Med Child Neurol 36 5: 441–448
DeLong GR (1992) Autism, amnesia, hippocampus, and learning. Neurosci Biobehav Rev 16 1: 63–70
Deonna T (1991) Acquired epileptiform aphasia in children (Landau-Kleffner Syndrome). J Clin Neurophysiol 8: 288–298
Egaas B, Courchesne E, Saitoh O (1995) Reduced size of corpus callosum in autism. Arch Neurol 52 8: 794–801
Filipek PA (1995) Quantitative magnetic resonance imaging in autism: The cerebellar vermis. Curr Opin Neurol 8: 134–138
Filipek PA, Richelme C, Kennedy DN, Rademacher J, Pitcher DA, Zidel S, Caviness VS (1992) Morphometric analysis of the brain in developmental language disorders and autism (abstract). Ann Neurol 32: 475
Folstein S, Rutter M (1977) Infantile autism: A genetic study of 21 twin pairs. J Child Psychol Psychiat 18 4: 297–321
Gaffney GR, Tsai LY, Kuperman S, Minchin S (1987) Cerebellar structure in autism. Am J Dis Child 141 12: 1330–1332
Gao J-H, Parsons LM, Bower JM, Xiong J, Li J, Fox PT (1996) Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science 272: 545–547
Garber HJ, Ritvo ER (1992) Magnetic resonance imaging of the posterior fossa in autistic adults. Am J Psychiat 149: 245–247
George MS, Costa DC, Kouris K, Ring HA, Ell PJ (1992) Cerebral blood flow abnormalities in adults with infantile autism. J Nerv Ment Dis 180 7: 413–417
Gillberg C (1986) Onset at age 14 of a typical autistic syndrome. A case report of a girl with herpes simplex encephalitis. J Autism Dev Disord 16 3: 369–375
Gillberg C, Trygstad O, Foss I (1982) Childhood psychosis and urinary excretion of peptides and protein-associated peptide complexes. J Autism Dev Disord 12 3: 229–241
Gillberg C, Terenius L, Lonnerholm G (1985) Endorphin activity in childhood psychosis: Spinal fluid in 29 cases. Arch Gen Psychiat 42 8: 780–783
Gillberg 1C (1991) Autistic syndrome with onset at age 31 years: Herpes encephalitis as a possible model for childhood autism. Dev Med Child Neurol 33 10: 920–924
Haas RH, Townsend J, Courchesne E, Lincoln AJ, Schreibman L, Yeung-Courchesne R (1996) Neurologic abnormalities in infantile autism. J Child Neurol 11: 84–92
Hallett M, Lebiedowska MK, Thomas SL, Stanhope SJ, Denckla MB, Rumsey J (1993) Locomotion of autistic adults. Arch Neurol 50 12: 1304–1308
Harter MR, Anllo-Vento L (1991) Visual-spatial attention: Preparation and selection in children and adults. In: Brunia CHM, Mulder G, Verbaten MN (eds) Event-related brain research. Elsevier, New York, p 183
Harter MR, Miller SL, Price NJ, LaLonde ME, Keyes AL (1989) Neural processes involved in directing attention. J Cogn Neurosci 1 3: 223–237
Hashimoto T, Tayama M, Miyazaki M, Murakawa K, Kuroda Y (1993) Brainstem and cerebellar vermis involvement in autistic children. J Child Neurol 8 2: 149–153
Hashimoto T, Tayama M, Murakawa K, Yoshimoto T, Miyazaki M, Harada M, Kuroda Y (1995) Development of the brainstem and cerebellum in autistic patients. J Autism Dev Disord 25 1: 1–18
Hauser KF, Gurwell JA, Turbek CS (1994) Morphine inhibits purkinje cell survival and dendritic differentiation in organotypic cultures of the mouse cerebellum. Exp Neurol 130 1: 95–105
Heilman KM, Watson RT, Valenstein E (1985) Neglect and related disorders. In Heilman KM, Valenstein E (eds) Clinical Neuropsychology 2nd ed, New York: Oxford University Press
Heinze HJ, Luck SJ, Mangun GR, Hillyard SA (1990) Visual event-related potentials index focused attention within bilateral stimulus arrays. I. Evidence for early selection. Electroencephalogr Clin Neurophysiol 75 6: 511–527
Hetzler BF, Griffin JL (1981) Infantile autism and the temporal lobe of the brain. J Autism Dev Disord 11 3: 317–330
Holttum JR, Minshew NJ, Sanders RS, Phillips NE (1992) Magnetic resonance imaging of the posterior fossa in autism. Biol Psychiat 32: 1091–1101
Hoon AH Jr, Reiss AL (1992) The mesial-temporal lobe and autism: Case report and review. Dev Med Child Neurol 34 3: 252–259
Hughes C, Russell J, Robbins TW (1994) Evidence for executive dysfunction in autism. Neuropsychologia 32 4: 477–492
Jones V, Prior M (1985) Motor imitation abilities and neurological signs in autistic children. J Autism Dev Disord 15 1: 37–46
Kemper TL, Bauman ML (1993) The contribution of neu-ropathologic studies to the understanding of autism. Behav Neurol 11 1: 175–187
Kim S-G, Ugurbil K, Strick PL (1994) Activation of a cerebellar output nucleus during cognitive processing. Science 265 5174: 949–951
Kleiman MD, Neff S, Rosman NP (1992) The brain in infantile autism: Are posterior fossa structures abnormal? Neurology 42 4: 753–760
Landau WM, Kleffner FR (1957) Syndrome of acquired aphasia with convulsive disorder in children. Neurology 7: 523–530
Leiner HC, Leiner AL, Dow RS (1986) Does the cerebellum contribute to mental operations? Behav Neurosci 100 4: 443–454
Leiner HC, Leiner AL, Dow RS (1991) The Human Cere-bro-Cerebellar System: Its Computing, Cogn Lang Skills Behav Brain Res 44 2: 114–128
Lovaas 01, Schreibman L, Koegel R, Rehm R (1971) Selective responding by autistic children to multiple sensory input. J Abn Psychol 773: 211–222
Mangun GR, Hillyard SA (1987) The spatial allocation of visual attention as indexed by event-related brain potentials. Human Factors 29 2: 195–211
Mangun GR, Hillyard SA (1988) Spatial gradients of visual attention: behavioral and electrophysiological evidence. Electroencephalogr Clin Neurophysiol 70 5: 417–428
Mangun GR, Hillyard SA (1990) Allocation of visual attention to spatial locations: Tradeoff functions for event-related brain potentials and detection performance. Percept Psychophysiology 47 6: 532–550
Marchetti B, Scifo R, Batticane N, Scapagnini U (1990) Immunological significance of opioid peptide dysfunction in infantile autism. Brain Dysfunct 3: 346–354
Martineau J, Barthélémy C, Jouve J, Muh JP, Lelord G (1992) Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: Age-related changes and drug effects. Dev Med Child Neurol 34 7: 593–603
Middleton FA, Strick PL (1994) Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science 266 5184: 458–461
Mountz JM, Tolbert LC, Lill BW, Katholi CR, Liu HG (1995) Functional deficits in autistic disorder: Characterization by technetium-99m-HMPAO and SPECT. J Nucl Med 36 7: 1156–1162
Murakami J, Courchesne E, Press G, Yeung-Courchesne R, Hesselink J (1989) Reduced cerebellar hemisphere size and its relationship to vermal hypoplasia in autism. Arch Neurol 46 6: 689–694
Newman PP, Reza H (1979) Functional relationships between the hippocampus and the cerebellum: An electrophysiological study of the cat. J Physiol 287: 405–426
Novick B, Kurtzberg D, Vaughan H Jr (1979) An electrophysiologic indication of defective information storage in childhood autism. Psychiat Res 01 1: 101–108
Novick B, Vaughan H Jr, Kurtzberg D, Simson R (1980) An electrophysiologic indication of auditory processing defects in autism. Psychiat Res 3 1: 107–114
Ornitz EM (1983) The functional neuroanatomy of infantile autism. Int J Neurosci 191-4: 85–124
Osborne JG, Kindy MS, Häuser KF (1991) Expression of proenkephalin mRNA in developing cerebellar cortex of the rat: Expression levels coincide with maturational gradients in purkinje cells. Dev Brain Res 63 1-2: 63–69
Osborne JG, Kindy MS, Spruce BA, Häuser KF (1993) Ontogeny of proenkephalin mRNA and enkephalin peptide expression in the cerebellar cortex of the rat: Spatial and temporal patterns of expression follow maturational gradients in the external granular layer and in purkinje cells. Dev Brain Res 761: 1–12
Ozonoff S, Pennington BF, Rogers SJ (1991) Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind. J Child Psychol Psychiat 32 7: 1081–1105
Pandya DN, Karol EA, Heilbronn D (1971) The topographical distribution of interhemispheric projections in the corpus callosum of the rhesus monkey. Brain Res 32: 31–43
Panksepp J (1979) A neurochemical theory of autism. Trends Neurosci 2: 174–177
Petersen SE, Fox PT, Posner MI, Mintun M, Raichle ME (1989) Positron emission tomographic studies of the processing of single words. J Cogn Neurosci 1 2: 153–170
Piven J, Nehme E, Simon J, Barta P, Pearlson G, Folstein SE (1992) Magnetic resonance imaging in autism: Measurement of the cerebellum, pons, and fourth ventricle. Biol Psychiat 31: 491–504
Piven J, Berthier ML, Starkstein SE, Nehme E, Pearlson G, Folstein S (1990) Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism. Am J Psychicat 147 6: 734–739
Piven J, Arndt S, Bailey J, Havercamp S, Andreasen NC, Palmer P (1995) An MRI study of brain size in autism. Am J Psychicat 152 8: 1145–1149
Piven J, Arndt S (1995) The cerebellum and autism. Neurology 45: 398–399
Posner MI (1980) Orienting of attention. Quarterly J Exp Psychol 32 1: 3–25
Posner MI, Walker JA, Friedrich FJ, Rafal RD (1984) Effects of parietal injury on covert orienting of attention. J Neurosci 4 7: 1863–1874
Posner MI, Walker JA, Friedrich FJ, Rafal RD (1987) How do the parietal lobes direct covert attention? Neuropsychologia 25 lA: 135–145
Raichle ME, Fiez JA, Videen TO, MacLeod AM, Pardo JV, Fox PT, Petersen SE (1994) Practice-related changes in human brain functional anatomy during nonmotor learning. Cerebral Cortex 4 1: 8–26
Raymond G, Bauman M, Kemper T (1989) The hippocampus in autism: Golgi analysis. Ann Neurol 26 3: 483–484
Reichelt KL, Knivsberg A-M, Lind G, Nodland M (1991) Probable etiology and possible treatment of childhood autism. Brain Dysfunct 4: 308–319
Reichelt KL, Knivsberg A-M, Nodland M, Lind G (1994) Nature and consequences of hyperpeptiduria and bovine casomorphins found in autistic syndromes. Dev Brain Dysfunct 7: 71–85
Reiss AL, Feinstein C, Rosenbaum KN (1986) Autism and genetic disorders. Schizophrenia Bull 12 4: 724–738
Ritvo ER, Freeman BJ, Scheibel AB, Duong T, Robinson H, Guthrie D, Ritvo A (1986) Lower purkinje cell counts in the cerebella of four autistic subjects: Initial findings of the UCLA-NSAC autopsy research report. Am J Psy-chiat 143 7: 862–866
Saitoh O, Courchesne E, Egaas B, Lincoln AJ, Schreibman L (1995) Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities. Neurology 45 2: 317–324
Schaefer GB, Thompson JN, Bodensteiner JB, McConnell JM, Kimberling WJ, Gay CT, Dutton WD, Hutchings DC, Gray SB (1996) Hypoplasia of the cerebellar vermis in neurogenetic syndromes. Ann Neurol 39 3: 382–385
Sears LL, Finn PR, Steinmetz JE (1994) Abnormal classical eye-blink conditioning in autism. J Autism Dev Disord 24 6: 737–751
Shattock P, Lowdon G (1991) Proteins, peptides and autism part 2: Implications for the education and care of people with autism. Brain Dysfunct 4: 323–334
Townsend J Courchesne E 1994 Parietal damage and narrow “spotlight” spatial attention. J Cogn Neurosci 63: 218–230
Townsend J, Courchesne E, Egaas, B (1996a) Slowed orienting of covert visual-spatial attention in autism: Specific deficits associated with cerebellar and parietal abnormality. Dev Psychopathol 8 3: 563–584
Townsend J, Singer-Harris N, Courchesne E (1996b) Visual attention abnormalities in autism: Delayed orienting to location. J Int Neuropsychol Soc
Vilensky JA, Damasio AR, Maurer RG (1981) Gait disturbances in patients with autistic behavior: A preliminary study. Arch Neurol 38 10: 646–649
Wainwright-Sharp JA, Bryson SE (1993) Visual orienting déficits in high-functioning people with autism. J Autism Dev Disord 23 1: 1–13
Williams K, Shattock P, Berney T (1991) Proteins, peptides and autism part 1: Urinary protein patterns in autism as revealed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and silver staining. Brain Dysfunct 4: 320–322
Williams RS, Hauser SL, Purpura DP, DeLong GR, Swisher CN (1980) Autism and mental retardation: Neuropath-ologic studies performed in four retarded persons with autistic behavior. Arch Neurol 37 12: 749–753
Zagon IS, Gibo DM, McLaughlin PJ (1990) Adult and developing human cerebella exhibit different profiles of opioid binding sites. Brain Res 523 1: 62–68
Zagon IS, McLaughlin PJ (1986a) Opioid antagonist (naltrexone) modulation of cerebellar maldevelopment: Histological and morphometric studies. J Neurosci 6 5: 1424–1432
Zagon IS, McLaughlin PJ (1986b) Opioid antagonist-induced modulation of cerebral and hippocampal development: Histological and morphometric studies. Dev Brain Res 28 2: 233–246
Zagon IS, McLaughlin PJ (1987) Endogenous opioid systems regulate cell proliferation in the developing rat brain. Brain Res 412 1: 68–72
Zagon IS, Rhodes RE, McLaughlin PJ (1985) Distribution of enkephalin immunoreactivity in germinative cells of developing rat cerebellum. Science 227 4690: 1049–1051
Zilbovicius M, Garreau B, Samson Y, Remy P, Barthélémy C, Syrota A, Lelord G (1995) Delayed maturation of the frontal cortex in childhood autism. Am J Psychiat 152 2: 248–252
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Belmonte, M., Carper, R. (1998). Neuroanatomical and neurophysiological clues to the nature of autism. In: Neuroimaging in child neuropsychiatric disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-95848-9_15
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