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Enzymes Controlling the Biosynthesis of Catecholamines

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Neuroblastomas

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 2))

Abstract

Isotopic studies have confirmed the proposed major pathway for the biogenesis of norepinephrine and epinephrine [1]. The main steps in this pathway are the oxidation of phenylalanine to tyrosine followed by hydroxylation to 3,4-dihydroxyphenylalanine, decarboxylation to dopamine, β-hydroxylation of dopamine to norepinephrine and N-methylation of norepinephrine to epinephrine. In addition, some other minor pathways were postulated (Fig. 1). Although evidence for the main pathway was well established a decade ago, only recently, all the enzymes which control the biosynthesis of catecholamines were isolated and their properties characterized. Based on these studies it is now possible to investigate the activities of these enzymes in tumors such as neuroblastoma and pheochromocytoma, and to determine which of those enzymes is responsible for the overproduction of catecholamines.

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Author information

Authors and Affiliations

  1. Neurochemistry Laboratories, Department of Psychiatry and Neurology, New York University Medical Center, New York 16, New York, USA

    M. Goldstein

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  1. M. Goldstein
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Editor information

C. Bohuon

Additional information

Dedicated to Professor I. äbelin, Bern, Switzerland.

Research Career Development Awardee of the United States Public Health Service, Grant. No. 5-K3-MH-14,1918-04 and also supported by the Grant of USPHS No. MH-02717-06.

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© 1966 Springer-Verlag Berlin · Heidelberg

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Goldstein, M. (1966). Enzymes Controlling the Biosynthesis of Catecholamines. In: Bohuon, C. (eds) Neuroblastomas. Recent Results in Cancer Research, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94971-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-94971-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-94972-2

  • Online ISBN: 978-3-642-94971-5

  • eBook Packages: Springer Book Archive

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