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Fibrinolysis and Vasoactive Peptides in Anaphylaxis

  • Conference paper
Hypotensive Peptides

Abstract

During the complex sequence of events in allergic and anaphylactic states, proteases, anticoagulants, histamine, 5-hydroxytryptamine, catecholamines, hypotensive polypeptides, and many other biologically active principles may appear in different animal species. The mechanism of activation and/or release of these factors is understood poorly, as are their respective roles in the biochemical chain of events in different types of shock.

This investigation was supported by Public Health Service Research Grants HE-08633 and HE-03784, National Heart Institute.

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References

  • Ambrus, J. L., C. M. Ambrus, J. E. Sokal, G. Markus, N. Back, L. Stutzman, R. Razis, C. A. Ross, B. H. Smith, A. C. Rekate, G. L. Collins, D. L. Kline, and J. B. Fishman: Clinical pharmacology of various types of fibrinolytic enzyme preparations. Amer. J. Cardiol. 6, 462 (1960).

    Article  Google Scholar 

  • Ambrus, C. M., D. H. Weintraub, D. Dunphy, J. E. Dowd, J. W. Pickren, K. R. Neiswander, and J. L. Ambrus: Studies on hyaline membrane disease. I. The fibrinolysin system in pathogenesis and therapy. Pediatrics 32, 10 (1963).

    CAS  Google Scholar 

  • Andersch, M. A.: Determination of proteins in cerebrospinal fluid by biuret method. Amer. J. clin. Path. Tech. Suppl. 8, 43 (1944).

    CAS  Google Scholar 

  • Astrup, T., and S. Mullertz: Fibrin plate method for estimating fibrinolytic activity. Arch. Biochem. 40, 346 (1952).

    Article  CAS  Google Scholar 

  • Austen, K. F., and J. H. Humphrey: In vitro studies of the mechanism of anaphylaxis. II. The role of pharmacological materials in in vivo anaphylaxis. Advanc. Immunol. 3, 18 (1963).

    Google Scholar 

  • Back, N.: Acquired resistance to the pharmacologic effects of plasmin. Study on tachyphylactogenic proteins. J. Pharmacol. exp. Ther. 130, 474 (1960).

    CAS  Google Scholar 

  • Back, N.: Fibrinolysin system and vasoactive kinins. Fed. Proc. 25: 77 (1966).

    CAS  Google Scholar 

  • Back, N., and R. Steger: Activation of bovine bradykininogen by human plasmin. Life Sci. 4, 153 (1965).

    Article  CAS  Google Scholar 

  • Back, N., and J. L. Ambrus:Fibrinolytic hemorrhage in surgical bleeding, in Handbook for Surgery and Specialties. New York: McGraw Hill-Blakiston Division, in press.

    Google Scholar 

  • Back, N., J. L. Ambrus, S. Goldstein, and J. W. E. Harrisson: In vivo fibrinolytic activity and pharmacology of various plasmin (fibrinolysin) preparations. Circulat. Res. 4, 440 (1956).

    CAS  Google Scholar 

  • Back, N., P. S. Guth, and A. E. Munson: On the relationship between plasmin and kinin. Ann. N. Y. Acad. Sci. 104, 53 (1963a).

    Article  CAS  Google Scholar 

  • Back, N., A. E. Munson, and P. S. Guth: Anaphylactic shock in dogs. Role of fibrinolysin and vasoactive polypeptide systems. J. Amer, med. Ass. 183, 260 (1963b).

    CAS  Google Scholar 

  • Back, N., M. Jainchill, H. Wilkens, and J. L. Ambrus: Effect of kallikrein, kinin and plasmin inhibitors on experimental burn shock. Submitted for publication.

    Google Scholar 

  • Back, N., H. Wilkens, A. E. Munson, and R. Steger: Trasylol in experimental shock states; a preliminary report. Germany: Schattauer Verlag, in press.

    Google Scholar 

  • Beraldo, W. T.: Formation of bradykinin in anaphylactic and peptone shock. Amer. J. Physiol. 163, 283 (1950).

    CAS  Google Scholar 

  • Brocklehurst, W. E., and S. C. Lahiri: The production of bradykinin in anaphylaxis. J. Physiol. (Lond.) 160, 15P (1962).

    Google Scholar 

  • Burdon, K. L., J. P. McGovern, G. D. Bar kin, and W. M. Meyers: Fibrinolysis and anaphylaxis I. Activation of blood fibrinolysin during acute anaphylactic shock in guinea pigs. J. Allergy 32, 55 (1961).

    Article  CAS  Google Scholar 

  • Cirstea, M., G. Suhaciu, and I. Butulescu: Bradykinin and anaphylactic shock in dogs, guinea-pigs and rabbits. Arch, int. Physiol. 73, 231 (1965).

    CAS  Google Scholar 

  • Dawson, W., and G. B. West: The importance of bradykinin in anaphylactic shock. J. Pharm. Pharmacol. 17, 246 (1965).

    Article  CAS  Google Scholar 

  • Diniz, C. R., and I. F. Carvalho: A micromethod for determination of bradykininogen under several conditions. Ann. N. Y. Acad. Sci. 104, 77 (1963).

    Article  CAS  Google Scholar 

  • Gans, H., and W. Krivit: Study of fibrinogen and plasminogen concentrations in rabbits during anaphylactic shock. J. Lab. clin. Med. 58, 259 (1961).

    CAS  Google Scholar 

  • Hicks, N. D., and W. R. Pitney: A rapid screening test for disorders of thromboplastin generation. Brit. J. Haemat. 3, 227 (1957).

    Article  CAS  Google Scholar 

  • Horton, E. W., and G. P. Lewis: A comparison of the plasma kinin forming enzymes in urine, kallikrein and urokinase. J. Physiol. (Lond.). 149, 477 (1960).

    Google Scholar 

  • Lecomte, J.: Consommation des kininogenes plasmatiques au cours du choc anaphylactique de lapin. C. R. Soc. Biol. (Paris) 155, 1411 (1961).

    CAS  Google Scholar 

  • Mayerson, H. S.: The physiologic importance of lymph, in Handbook of Physiology. Washington: Amer. Physiol. Soc. (1963).

    Google Scholar 

  • Mackay, M.: The activation of endogenous plasma proteolytic enzymes. Vox Sang. (Basel) 8, 489 (1963).

    CAS  Google Scholar 

  • Nicola, P. de: Thrombelastography. Springfield: Thomas (1957).

    Google Scholar 

  • Nolf, P.: Contribution a l’etude de la coagulation. V. Fibrinolyse. Arch, int. Physiol. 6, 306 (1908).

    Google Scholar 

  • Owren, P. A., and K. Aas: Control of dicumarol therapy and quantitative determinations of prothrombin and proconvertin. Scand. J. clin. Lab. Invest. 3, 201 (1951).

    Article  CAS  Google Scholar 

  • Quick, A. J., C. R. Honorato, and M. Stefanini. Value and limitations of coagulation times in study of hemorrhagic diseases. Blood 3, 1120 (1948).

    CAS  Google Scholar 

  • Rocha e Silva, M.: The role played by leukocytes and platelets in anaphylactic and peptone shock. Ann. N. Y. Acad. Sci. 50, 1045 (1950).

    Article  Google Scholar 

  • Rocha e Silva, M.: Biochemistry and Pharmacology of Bradykinin in Polypeptides Which Affect Smooth Muscles and Blood Vessels, p. 210. New York: Pergamon (1960).

    Google Scholar 

  • Rodman, N. F., E. M. Barrow, and J. B. Graham: Diagnosis and control of the hemophiloid states with the partial thromboplastin time (PTT) test. Amer. J. clin. Path. 29, 525 (1958).

    Google Scholar 

  • Salmon, J., and J. Lecomte: Role de la fibrinolyse dans le choc anaphylactique du lapin. Int. Arch. Allergy 22, 378 (1962).

    Article  Google Scholar 

  • Scharnagel, K. von, K. Greeff, R. Lühr and H. Strobach: Freisetzung von bradykinin beim toxischen, anaphylaktischen, und anaphylaktoiden shock. Naunyn-Schmiedeberg’s Arch, exp. Path. Pharmak. 250, 176 (1965).

    Article  CAS  Google Scholar 

  • Stefanini, M., and W. Dameshek: The Hemorrhagic Disorders. New York: Grune and Stratton, 1962.

    Google Scholar 

  • Stormorken, H., and T. F. Newcomb: The use of buffers in blood coagulation studies. Scand. J. clin. Lab. Invest. 9, 237 (1957).

    Article  Google Scholar 

  • Ungar, G., and H. Hayashi: Enzymatic mechanisms in allergy. Ann. Allergy 16, 542 (1958).

    CAS  Google Scholar 

  • Ungar, G., T. Yamura, J. B. Isola, and S. Kobrin: Further studies on the role of proteases in the allergic reaction. J. exp. Med. 113, 359 (1961).

    Article  CAS  Google Scholar 

  • Wycoff, H. D.: A microassay for plasma fibrinogen. J. Lab. Clin. Med. 47, 645 (1956).

    CAS  Google Scholar 

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Back, N., Wilkens, H., Steger, R. (1966). Fibrinolysis and Vasoactive Peptides in Anaphylaxis. In: Erdös, E.G., Back, N., Sicuteri, F., Wilde, A.F. (eds) Hypotensive Peptides. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94965-4_47

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  • DOI: https://doi.org/10.1007/978-3-642-94965-4_47

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-94967-8

  • Online ISBN: 978-3-642-94965-4

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