Skip to main content

The Age Structure of Populations of Cells Reproducing by Asymmetric Division

  • Conference paper
Mathematics in Biology and Medicine

Part of the book series: Lecture Notes in Biomathematics ((LNBM,volume 57))

Abstract

The purpose of this paper is to present a new model for the growth and age structure of a population of a species which reproduces by asymmetric division, i.e. cell reproduction where one clearly can distinguish between the mother and the daughter cell after division as opposed to division patterns where each fission produces two equal daughter cells. The cells of such populations are thus naturally divided into different classes according to the number of divisions they have undergone. A typical example of an organism which divides asymmetrically is Sacehavomyees oevevisiae, which reproduces by budding. After each cell separation a bud scar is left on the wall of the mother cell. These scars can be counted using electron microscopy. We say that a cell with i offsprings and hence i bud scars belongs to the ith scar class. It is supposed that cells of different scar classes behave in a different way, for instance with respect to cell growth and metabolism activity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J. Adams, E.D. Rothman and K. Beran, The age structure of populations of Saceharomyees eerevisiae, Math. Biosei. 53 (1981), 249–263.

    Article  Google Scholar 

  2. K. Beran, Budding of yeast cells, their scars and ageing, Advan. Microb. Physiol. 2 (1968), 143–171.

    Article  Google Scholar 

  3. J. Gani and I.W. Saunders, Fitting a model to the growth of yeast colonies, Biometrics 33 (1977), 113–120.

    Article  MATH  Google Scholar 

  4. M. Gyllenberg, Age-dependent population dynamics in continuously propagated bacterial cultures, Report No. 8, Helsinki Univ. of Tech. Inst, of Mech., 1981.

    Google Scholar 

  5. M. Gyllenberg, Nonlinear age-dependent population dynamics in continuously propagated bacterial cultures, Math. Biosoi. 62 (1982), 45–74.

    Article  MATH  MathSciNet  Google Scholar 

  6. M. Gyllenberg, Stability of a nonlinear age-dependent population model containing a control variable, SIAM J. Appl. Math., to appear.

    Google Scholar 

  7. T. Hamada, S. Kanno, E. Kano, Stationary stage structure of yeast population with stage dependent generation time, J. Theor. Biol. 97 (1982) 393–414.

    Article  Google Scholar 

  8. T. Hamada, Y. Nakamura, On the oscillatory transient stage structure of yeast population, J. Theor. Biol. 99 (1982) 797–805.

    Article  MathSciNet  Google Scholar 

  9. L.H. Hartwell, Saceharomyees eerevisiae cell cycle, Bacterial. Rev. 38 (1974) 164–198.

    Google Scholar 

  10. L.H. Hartwell and M.W. Unger, Unequal division in Saceharomyees eerevisiae and its implications for the control of cell division, J. Cell. Biol. 75 (1977) 422–435.

    Article  Google Scholar 

  11. M.A. Hjortso, J.E. Baîley, Transient responses of budding yeast populations, Math. Biosei. 63 (1983) 121–148.

    Article  MATH  Google Scholar 

  12. M.A. Hjortso, J.E. Bailey, Steady-state growth of budding yeast populations in well-mixed conti nuous-f low mi crobial reactors, Math. Biosci. 60 (1982) 235–263.

    Article  MATH  MathSciNet  Google Scholar 

  13. A.I. Markushevich, Theory of functions of a complex variable, Vol. 2, English translation, Prentice-Hall inc., Englewood Cliffs, N.J., 1965.

    Google Scholar 

  14. H.K. von Meyenburg, Der Sprossugszyklus von Saoehavomyees eevevisiae, Pathol. Microbiol. 31 (1968) 117–127. Added in proof:

    Google Scholar 

  15. S. Tuljapurkar, Transient dynamics of yeast populations, Math. Biosoi. 64 (1983) 157–168.

    Article  MATH  MathSciNet  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Gyllenberg, M. (1985). The Age Structure of Populations of Cells Reproducing by Asymmetric Division. In: Capasso, V., Grosso, E., Paveri-Fontana, S.L. (eds) Mathematics in Biology and Medicine. Lecture Notes in Biomathematics, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93287-8_44

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-93287-8_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15200-2

  • Online ISBN: 978-3-642-93287-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics