Abstract
During the past few years a number of studies have shown an association between human histocompatibility (HLA) antigens and certain diseases. The search for associations between HLA and specific diseases in man was stimulated by the discovery, in several animal species, of specific immune response (Ir) genes closely linked to the species histocompatibility system. Although early studies in man showed only weak associations with Hodgkin’s and some other diseases, subsequent studies have shown very striking associations with a number of diseases. Many of these diseases have a presumptive or suspected autoimmune aetiology, including ankylosing spondylitis, psoriasis, coelica disease, myasthenia gravis and multiple sclerosis. Weak associations have been found with some cancers and with some diseases which are possibly due to infectious agents (McDevitt and Bodmer 1974; Svejgaard et al. 1975).
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Thomson, G., Bodmer, W.F. (1977). The Genetics of HLA and Disease Associations. In: Christiansen, F.B., Fenchel, T.M. (eds) Measuring Selection in Natural Populations. Lecture Notes in Biomathematics, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-93071-3_32
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DOI: https://doi.org/10.1007/978-3-642-93071-3_32
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