Abstract
Most studies of drug self-administration have concerned either opiate, depressant, or stimulant drugs (Schuster and Thompson, 1969). Few studies have involved hallucinogenic drug self-administration, primarily because of technical problems (e.g., long duration of action, lack of water solubility) associated with the use of these drugs. The present study investigates the intravenous self-administration of phencyclidine and Δ9-THC, and the self-administration by smoking of a natural cannabis substance (hashish). Phencyclidine is a synthetic anticholinergic drug with hallucinogenic properties (Brawley and Duffield, 1972). Cannabis compounds have been used by man for thousands of years primarily for their behavioral effects and contain Δ9-THC as the principal active ingredient (Mechoulam, 1970). Deneau and Kaymakcalan (1971) have reported intravenous self-administration of THC by monkeys, but only after physical dependence had been established to the drug. No report of phencyclidine self-administration by animals has been found.
This research supported in part by U.S.P.H.S. Research Grants No. MH-14112 and MH15349 to the University of Minnesota.
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References
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Pickens, R.W., Thompson, T., Muchow, D.C. (1973). Cannabis and Phencyclidine Self-Administration by Animals. In: Goldberg, L., Hoffmeister, F. (eds) Psychic Dependence. Bayer-Symposium, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87987-6_11
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DOI: https://doi.org/10.1007/978-3-642-87987-6_11
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