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Structure of the Complex Formed by Bovine Trypsin and Bovine Pancreatic Trypsin Inhibitor Refinement of the Crystal Structure Analysis

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Proteinase Inhibitors

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

The serine proteinases and their natural inhibitors interact very strongly and specifically. There is evidence that enzymatic catalysis is involved in this interaction [1, 2]. The structure analysis of the free pancreatic trypsin inhibitor (PTI) has suggested that it is ideally shaped to cover the active site area of the serine proteinases [3, 4], This was borne out by model building studies with α-chymo-trypsin and PTI [5] and by the crystal structure analysis of the complex of trypsin with PTI [6].

Supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 51 and the Royal Society European Fellowship (A. J.).

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Author information

Authors and Affiliations

  1. Max-Planck-Institut für Biochemie, Martinsried and Physikalisch-Chemisches Institut der Technischen Universität München, 8000, Munich, Fed. Rep. Germany

    R. Huber, D. Kukla, W. Steigemann, J. Deisenhofer & A. Jones

  2. Biophysics Department, Kings College, London, UK

    A. Jones

Authors
  1. R. Huber
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  2. D. Kukla
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  3. W. Steigemann
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  4. J. Deisenhofer
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  5. A. Jones
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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© 1974 Springer-Verlag

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Huber, R., Kukla, D., Steigemann, W., Deisenhofer, J., Jones, A. (1974). Structure of the Complex Formed by Bovine Trypsin and Bovine Pancreatic Trypsin Inhibitor Refinement of the Crystal Structure Analysis. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_55

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_55

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87968-5

  • Online ISBN: 978-3-642-87966-1

  • eBook Packages: Springer Book Archive

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