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The Mechanism of Association of Trypsin (or Chymotrypsin) with the Pancreatic Trypsin Inhibitors (Kunitz and Kazal) Kinetics and Thermodynamics of the Interaction

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Proteinase Inhibitors

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 5))

Abstract

This paper is a survey of our recent work concerning the dynamics of the association of trypsin and chymotrypsin with the pancreatic trypsin inhibitors, that is, the Kunitz inhibitor (PTI)1 and the Kazal (secretory) inhibitor (PSTI).

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Abbreviations

PTI:

virgin basic pancreatic trypsin inhibitor (Kunitz inhibitor)

R*PTI:

basic pancreatic trypsin inhibitor selectively reduced at S-S 14-38

RCAM*PTI:

carboxamidomethylated R*PTI

RAE*PTI:

aminoethylated R*PTI

PTI*GL15 :

PTI selectively guanidinated at Lysine 15

PSTI:

pancreatic secretory trypsin inhibitor (Kazal inhibitor)

RCOM*-trypsin:

trypsin selectively reduced and carboxymethylated at S-S 179-203

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Author information

Authors and Affiliations

  1. Institut de Biochimie, Faculté des Sciences, Université de Nice, F-06034, Nice, France

    M. Lazdunski, J.-P. Vincent & H. Schweitz

  2. Institut de Biochimie, Faculté des Sciences d’Orsay, Université de Paris-Sud, 91 Orsay, France

    M. Péron-Renner & J. Pudles

Authors
  1. M. Lazdunski
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  2. J.-P. Vincent
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  3. H. Schweitz
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  4. M. Péron-Renner
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  5. J. Pudles
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Editor information

Editors and Affiliations

  1. Institut für Klinische Chemie und Klinische Biochemie, Universität München, 8000, Munich 2, Fed. Rep. Germany

    Hanz Fritz

  2. Organisch-Chemisches Laboratorium, Technischen Universität München, 8000, Munich 2, Fed. Rep. Germany

    Harald Tschesche

  3. Department of Biology, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Lewis J. Greene

  4. Biochemisches Laboratorium, Bayer AG, 5600, Wuppertal 1, Fed. Rep. Germany

    Ernst Truscheit (Editor-in-Chief) (Editor-in-Chief)

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Lazdunski, M., Vincent, JP., Schweitz, H., Péron-Renner, M., Pudles, J. (1974). The Mechanism of Association of Trypsin (or Chymotrypsin) with the Pancreatic Trypsin Inhibitors (Kunitz and Kazal) Kinetics and Thermodynamics of the Interaction. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_47

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  • DOI: https://doi.org/10.1007/978-3-642-87966-1_47

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-87968-5

  • Online ISBN: 978-3-642-87966-1

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