Abstract
In considering the kinetic behavior and possible functions of germinal centers during immune responses, experimental conditions wherein de novoformation and growth of these structures can be followed are of special interest. It has been demonstrated (Cottieret al., 1964; Cottier et al., 1966) that a delimited situation exists during secondary antibody responses to tetanus toxoid in mice under the following conditions:
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1.
a time interval of several months is used between the first and second injection of antigen;
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2.
the site of secondary stimulation differs from the site of primary immunization;
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and
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3.
the booster injection is given at a site where the draining lymph nodes in non-stimulated animals contain no, or only a few, germinal centers.
Supported by the U.S. Atomic Energy Commission and the Swiss National Foundation for Scientific Research. Work performed by Dr. G. Keiser under contract with National Institute of Health, Bethesda, Md (International Postdoctoral Fellowship).
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References
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Cottier, H., Keiser, G., Odartchenko, N., Hess, M., Stoner, R.D. (1967). De novo Formation and Rapid Growth of Germinal Centers During Secondary Antibody Responses to Tetanus Toxoid in Mice. In: Cottier, H., Odartchenko, N., Schindler, R., Congdon, C.C. (eds) Germinal Centers in Immune Responses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86837-5_33
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DOI: https://doi.org/10.1007/978-3-642-86837-5_33
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