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Ontogenetic Development of the Germinal Centers and Their Function — Relationship to the Bursa of Fabricius

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Germinal Centers in Immune Responses

Abstract

In this presentation we shall briefly review the evidence which suggests that the lymphoid cells of germinal centers in chickens are direct descendants of lymphoid cells of the bursa of Fabricius; these cells appear to represent intermediate stages in plasma cell differentiation. Further, we shall present evidence that Peyer’s patch type of intestinal lymphoid tissues serve as the mammalian counterpart of the avian bursa.

Aided by grants from the U.S. Public Health Service (NB-02042, HE-02085, 9TI-AI-292) National Foundation, American Heart Association, and American Cancer Society.

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Author information

Authors and Affiliations

  1. Faculty Research Associate, American Cancer Society, USA

    M. D. Cooper

  2. American Heart Association, USA

    R. D. A. Peterson (Established Investigator)

  3. American Legion Memorial Heart Research Professor of Pediatrics and Microbiology, USA

    R. A. Good

  4. Pediatric Research Laboratories of the Variety Club Heart Hospital, USA

    R. A. Good

  5. Department of Microbiology, University of Minnesota, USA

    R. A. Good

Authors
  1. M. D. Cooper
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  2. A. E. Gabrielsen
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  3. R. D. A. Peterson
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  4. R. A. Good
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Editor information

Editors and Affiliations

  1. Institute of Pathology, University of Bern, Switzerland

    H. Cottier  & R. Schindler  & 

  2. Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

    N. Odartchenko  & R. Schindler  & 

  3. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    C. C. Congdon

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© 1967 Springer-Verlag Berlin · Heidelberg

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Cooper, M.D., Gabrielsen, A.E., Peterson, R.D.A., Good, R.A. (1967). Ontogenetic Development of the Germinal Centers and Their Function — Relationship to the Bursa of Fabricius. In: Cottier, H., Odartchenko, N., Schindler, R., Congdon, C.C. (eds) Germinal Centers in Immune Responses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86837-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-86837-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86839-9

  • Online ISBN: 978-3-642-86837-5

  • eBook Packages: Springer Book Archive

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