Abstract
One of the interesting facets of the effect of immunosuppressant agents on the immune response is that under certain conditions suppression of a specific part of the response can be obtained while other aspects remain relatively unaffected. Examples of this phenomenon can be found in the selective suppression of the 7 S antibody response by certain doses of 6-mercaptopurine (Sahiar and Schwartz, 1965; Borel et al., 1965), cyclophosphamide (Santos and Owens, 1966), and X-irradiation (Svehag and Mandel, 1964; Robbins and Smith, 1964). Much higher doses of these agents are required to suppress the secondary response, once immunological memory to an antigen has been established, than are needed for abolishing a primary response (LaPlante et al., 1962; Schwartz et al., 1959; Butler and Coons, 1964). However, if drugs are given during the primary in such a manner as to completely suppress the primary response, the establishment of an immunological memory (“priming”) is often also prevented (Butler and Coons, 1964), and in extreme cases immunological tolerance may ensue (Schwartz and Dameshek, 1959; Linscott and Weigle, 1965).
Supported by Grant # AI-3076 from the United States Public Health Service.
This study was performed during the tenure by Dr. J. Hurlimann of a fellowship from the Swiss Academy of Medicine.
Recipient of Career Development Award 2-K3-GM-15, 522.
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Hurlimann, J., Wakefield, J.D., Thorbecke, G.J. (1967). The Effects of Immuno Suppressant Drugs Administered During Germinal Center Proliferation on Preparation for a Secondary Antibody Response in Rabbits. In: Cottier, H., Odartchenko, N., Schindler, R., Congdon, C.C. (eds) Germinal Centers in Immune Responses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86837-5_28
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DOI: https://doi.org/10.1007/978-3-642-86837-5_28
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