Abstract
Histologic and autoradiographic studies of spleen lymphatic tissue demonstrate progressive shifts of affected cell populations in response to antigen stimulation. Earliest histologic changes observed during the immune response involve lymphatic tissue germinal centers, and various investigators have suggested that these centers are an integral part of the immune system (Congdon and Makinodan, 1964;Congdon and Goodman, 1962; Conway, 1937; Cottier et al., 1964; Hanna, 1965; Hanna et al., 1966; Hellman and White, 1930; Nossal, 1962; Ringertz and Adamson, 1950; Swartzendruber and Hanna, 1965; and Ward et al., 1959). Three consistent histologic findings during the early period of spleen lymphatic tissue reaction to an antigenic stimulation of 1 ml of 10% sheep erythrocyte suspension have been reported (Congdon and Makinodan, 1964; Hanna, 1965; Hanna et al., 1966). The first change is germinal center loss or dissociation; the second is the occurrence of large pyronin-staining cells throughout the lymphatic nodule and splenic red pulp. The presence and general significance of large pyronin-staining cells for reaction to antigenic material has been recognized for some time, and these cells are thought by many investigators to be the source of plasma cells and other immunologic phenomena (Andre-Schwartz, 1964; Capalbo andMakinodan, 1964; Coons et al., 1955; Fagraeus, 1948; Marshall and White, 1950; Nossal and Mäkelä, 1962; Rich et al., 1939; Ringertz and Adamson, 1950; and Schooley, 1961). The third change is germinal center recovery, with hyperplasia beginning 2 days after antigen injection.
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Hanna, M.G., Swartzendruber, D.C., Congdon, C.C. (1967). Morphologic and Autoradiographic Studies of Spleen White Pulp Germinal Centers after Antigen Injection. In: Cottier, H., Odartchenko, N., Schindler, R., Congdon, C.C. (eds) Germinal Centers in Immune Responses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86837-5_24
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DOI: https://doi.org/10.1007/978-3-642-86837-5_24
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