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Pharmakologische Untersuchungen zur antidepressiven Wirkung von Hypericum perforatum L.

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Phytopharmaka in Forschung und klinischer Anwendung

Zusammenfassung

Als Ursache von Depressionen werden Serotonin- oder Katecholaminmangelzustände an spezifischen Rezeptoren im zentralen Nervensystem diskutiert [10]. Dieser Theorie entspricht der Wirkmodus der klassischen Antidepressiva, die die Wiederaufnahme von Serotonin und/oder Noradrenalin in die präsynaptische Nervenendigung hemmen oder den enzymatischen Abbau der Monoamine, beispielsweise durch eine Hemmung der Monoaminoxidase, unterdrücken. Beide Effekte führen akut zu einem erhöhten Angebot an Monoaminen. Durch die Veränderung der Monoaminkonzentration im synaptischen Spalt sowie durch Rezeptorblockade soll nach längerer Behandlungsdauer die Dichte der Neurotransmitterrezeptoren verändert werden. Allerdings reichen diese Mechanismen nicht aus, um die Wirksamkeit aller Antidepressiva zu erklären. Sie begründen auch nicht die Latenzzeit von mehreren Wochen, die zwischen dem Beginn der Pharmakotherapie und dem Eintreten der stimmungsaufhellenden Wirkung liegt [10].

Teilweise Bestandteil der geplanten Dissertation von V. Butterweck.

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Author information

Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Universität Münster, Domagkstraße 12, 48149, Münster, Deutschland

    Frau Prof. Dr. H. Winterhoff, V. Butterweck, H. G. Gumbinger, S. Erping, F. Boßhammer & A. Wieligmann

  2. Institut für Pharmazeutische Biologie, Universität Münster, Deutschland

    V. Butterweck & A. Nahrstedt

  3. Lichtwer Pharma GmbH, Berlin, Deutschland

    V. Schulz

Authors
  1. Frau Prof. Dr. H. Winterhoff
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  2. V. Butterweck
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  3. A. Nahrstedt
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  4. H. G. Gumbinger
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  5. V. Schulz
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  6. S. Erping
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  7. F. Boßhammer
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  8. A. Wieligmann
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Editor information

Editors and Affiliations

  1. Abteilung für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, Sandhofstraße 74, 60590, Frankfurt am Main, Deutschland

    Dieter Loew  & Norbert Rietbrock  & 

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© 1995 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Winterhoff, H. et al. (1995). Pharmakologische Untersuchungen zur antidepressiven Wirkung von Hypericum perforatum L. . In: Loew, D., Rietbrock, N. (eds) Phytopharmaka in Forschung und klinischer Anwendung. Steinkopff. https://doi.org/10.1007/978-3-642-85434-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-85434-7_4

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85435-4

  • Online ISBN: 978-3-642-85434-7

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