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Regulation of Expression and Pathogenic Potential of Human Foamy Virus In Vitro and in Transgenic Mice

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Transgenic Models of Human Viral and Immunological Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 206))

Abstract

Increasing scientific interest in the foamy virus subgroup of retroviruses during the last few years has been due to two discoveries; (1) the molecular biology of foamy viruses shows some close similarities to that of lentiviruses and of the HTLV/BLV group of retroviruses, in addition to some features which set the foamy viruses apart from all other retroviruses. Moreover (2), transgenic mouse systems demonstrated for the first time a pathogenic potential of foamy viruses, i.e., induction of a fatal encephalopathy and myopathy in mice expressing various combinations of foamy virus genes.

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Authors and Affiliations

  1. Institute of Neuropathology, Department of Pathology, University of Zürich, Schmelzbergstrasse 12, 8091, Zürich, Switzerland

    A. Aguzzi, S. Marino & R. Tschopp

  2. Institute of Virology, University of Würzburg, Versbacherstrasse 7, 97078, Würzburg, Germany

    A. Rethwilm

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  1. A. Aguzzi
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  2. S. Marino
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  3. R. Tschopp
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  4. A. Rethwilm
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Editors and Affiliations

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Francis V. Chisari M.D. (Member, Head) (Member, Head)

  2. Division of Experimental Pathology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Francis V. Chisari M.D. (Member, Head) (Member, Head)

  3. Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D. (Member, Head) (Member, Head)

  4. Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D. (Member, Head) (Member, Head)

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© 1996 Springer-Verlag Berlin Heidelberg

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Aguzzi, A., Marino, S., Tschopp, R., Rethwilm, A. (1996). Regulation of Expression and Pathogenic Potential of Human Foamy Virus In Vitro and in Transgenic Mice. In: Chisari, F.V., Oldstone, M.B.A. (eds) Transgenic Models of Human Viral and Immunological Disease. Current Topics in Microbiology and Immunology, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85208-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-85208-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85210-7

  • Online ISBN: 978-3-642-85208-4

  • eBook Packages: Springer Book Archive

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