Abstract
In some critically ill patients, particularly those with the Adult Respiratory Distress Syndrome (ARDS) or sepsis, oxygen (O2) uptake has been observed to change in the same direction with any change in O2 delivery (the product of cardiac output and arterial O2 concentration). These changes have been seen at levels of O2 delivery where O2 uptake is normally independent of delivery. The principal reason appears to be an inability of peripheral tissues to alter O2 extraction appropriately. There are, however, several features of this pathological O2 supply dependency which are still poorly understood and which may have serious implications for the outcome in any particular case.
Funds to support the research reported here were obtained from the National Institutes of Health (HL 26927) and Fisons Pharmaceuticals plc.
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© 1991 Springer-Verlag Berlin Heidelberg
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Cain, S.M. (1991). Physiological and Pathological Oxygen Supply Dependency. In: Gutierrez, G., Vincent, J.L. (eds) Tissue Oxygen Utilization. Update in Intensive Care and Emergency Medicine, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84169-9_9
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DOI: https://doi.org/10.1007/978-3-642-84169-9_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-52472-4
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