Rapamycin: A New and Highly Active Immunosuppressive Macrolide with an Efficacy Superior to Cyclosporine

Meiser, B. M.; Wang, J.; Morris, R. E.

doi:10.1007/978-3-642-83755-5_159

B. M. Meiser,
J. Wang &
R. E. Morris

103 Accesses
8 Citations

Abstract

In 1975, as part of a program at Ayerst Research Laboratories in Montreal to screen for non-polyene antifungal antibiotics, Dr Sehgal’s group (Sehgal 1975) discovered that a fermentation product of the fungus Streptomyces hygroscopicus inhibited Candida albicans and dermatophytes (Vézina 1975; Baker 1978; Singh 1979). The active anti-fungal principle was isolated and determined to be a novel 31-membered macrolide lactone with a FW of 914.2 and the molecular formula C₅₁H₇₉NO₁₃ (Swindells 1978). The antibiotic was named rapamycin (RPM) since the streptomycete had been isolated from a soil sample collected during an expedition of caves on Easter Island (Rapa nui).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Chapter: USD 29.95; Price excludes VAT (USA)

eBook: USD 74.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

References

Baker H, Sidorowicz A, Sehgal SN, Vezina C (1978) J Antibiotics 31: 539–545
Article CAS Google Scholar
Borel JF, Feurer C, Gubler HU (1976) Agents Actions 6: 468–475
Article CAS PubMed Google Scholar
Calne RY, Collier DSJ, Lim S, Pollard SG, Samaan A, White DJG, Thiru S (1989) The Lancet 2: 227
Article CAS Google Scholar
Eng CP, Sehgal SN, Vezina C (1984) J Antibiotics 37: 1231–1237
Article CAS Google Scholar
Homan WP, Keryn AW, Millard PR, Morris PJ (1981) Transplantation 31: 423–427
Article CAS PubMed Google Scholar
Houchens DP, Ovejera AA, Riblet SM, Sagels DE (1983) Eur J Cancer Clin Oncol 19: 799–805
Article CAS PubMed Google Scholar
Kino T, Hatanaka M, Hashimoto M, Nishiyama M, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H (1987) J Antibiotics 40: 1249–1255
Article CAS Google Scholar
Martel RR, Klicius J, Galet S (1977) Can J Physiol Pharmacol 55: 48–51
Article CAS PubMed Google Scholar
Meiser BM, Morris RE (1989) Tansplantation [submitted]
Google Scholar
Morris RE, Hoyt EG, Murphy MP, Shorthouse R (1989) Trans Proc 21: 1042–1044
CAS Google Scholar
Morris RE, Meiser BM (1989) Med Sci Res 17: 609–610
CAS Google Scholar
Sehgal SN, Baker H, Venzia C (1975) J Antibiotics 28: 727–732
Article CAS Google Scholar
Singh K, Sun S, Venzia C (1979) J Antibiotics 32: 630–645
Article CAS Google Scholar
Swindells DCN, White PS, Findlay JA (1978) Can J Chem 56: 2491–2492
Article CAS Google Scholar
Tanaka H, Kuroda A, Marusawa H, Hatanaka H, Kino T, Goto T, Hashimoto M (1987) J Am Chem Soc 109: 5031–5033
Article CAS Google Scholar
Thomson AW (1989) Immunology Today 10: 6–9
Article CAS PubMed Google Scholar
Vézina C, Kudelski A, Sehgal SN (1975) J Antibiotics 28: 721–726
Article Google Scholar

Download references

Authors

B. M. Meiser
View author publications
You can also search for this author in PubMed Google Scholar
J. Wang
View author publications
You can also search for this author in PubMed Google Scholar
R. E. Morris
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

Basel Institute for Immunology, Grenzacherstrasse 487, 4005, Basel, Switzerland
Fritz Melchers , H. von Boehmer & L. Du Pasquier , &
Labor für Immungenetik, Kinderpoliklinik der Universität, Pettenkoferstrasse 8a, 8000, München 2, Germany
E. D. Albert
Institut für Hygiene, Universität Innsbruck und Ludwig Boltzmann-Institut für AIDS-Forschung, Fritz-Pregl-Strasse 3, 6010, Innsbruck, Austria
M. P. Dierich
Max-Planck-Institut für Immunbiologie, Stübeweg 51, 7800, Freiburg, Germany
K. Eichmann
Med.Zentrum für Hygiene und Medizinische Mikrobiologie, Institut für Immunologie, Robert-Koch-Straße 8, 3550, Marburg, Germany
D. Gemsa
Abteilung Immunologie, Zentrum Hygiene und Humangenetik, Kreuzbergring 57, 3400, Göttingen, Germany
O. Götze
Institut und Poliklinik für klinische Immunologie und Rheumatologie, Krankenhausstraße 12, 8520, Erlangen, Germany
J. R. Kalden
Abt.Med.Mikrobiologie und Immunologie der Universität, Albert-Einstein-Allee 11, 7900, Ulm/Donau, Germany
S. H. E. Kaufmann
Institut für Immunologie Transfusionsmedizin, Ratzeburger Allee 160, 2400, Lübeck 1, Germany
H. Kirchner
Medizinische Hochschule Hannover Molekularpharmakologie, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Germany
K. Resch
Institut für Immunologie, Ludwig-Maximilians-Universität, Goethestrasse 31, 8000, München 2, Germany
G. Riethmüller
Institut für Virologie und Immunbiologie, Versbacher Strasse 7, 8700, Würzburg, Germany
A. Schimpl
Zentrum für Dermatologie Institut für Experimentelle Dermatologie, Von-Esmarch-Strasse 56, 4400, Münster, Germany
C. Sorg
F.Hoffmann-La Roche Co Ltd, ZFE, 4002, Basel, Switzerland
M. Steinmetz
Inst. für Med. Mikrobiologie und Hygiene, TU München Klinikum rechts der Isar, Trogerstrasse 9, 8000, München 80, Germany
H. Wagner
Institut für Physiologische Chemie, Universität München, Goethestr. 33, 8000, München 2, Germany
H. G. Zachau

Rights and permissions

Reprints and permissions

Copyright information

About this paper

Cite this paper

Meiser, B.M., Wang, J., Morris, R.E. (1989). Rapamycin: A New and Highly Active Immunosuppressive Macrolide with an Efficacy Superior to Cyclosporine. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_159

Download citation

DOI: https://doi.org/10.1007/978-3-642-83755-5_159
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83757-9
Online ISBN: 978-3-642-83755-5
eBook Packages: Springer Book Archive

Publish with us

Policies and ethics