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The Nervous System: Radiobiology and Experimental Pathology

  • Chapter
Radiopathology of Organs and Tissues

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Some of the most extensive studies on the acute and delayed effects of radiation on the brain have been done in rhesus monkeys, notably by Haymaker (1969) and Caveness (1980). In the studies by Haymaker dose-response relationships are difficult to establish because monkeys were whole body irradiated with high energy protons and an inhomogeneous dose distribution. Because of the limited penetration of the lower energy protons (32 and 55 MeV), several monkeys survived long enough for some insight to be obtained into the delayed responses of the brain. The importance of Haymaker’s review (1969) is the consideration of the role of various cell types in acute and delayed radiation-induced lesions in the CNS. Neurons have been shown to be extraordinarily radioresistant, with doses as high as 4000 Gy required to destroy a nerve cell within 24 days in a very small irradiated volume.

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Authors and Affiliations

  1. Institute of Radiotherapy, University of Nijmegen, Geert Grooteplein Zuid 32, 6525 GA, Nijmegen, The Netherlands

    Professor Dr. A. J. van der Kogel

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  1. Professor Dr. A. J. van der Kogel
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  1. Strahlenklinik und Poliklinik, Universitätsklinikum der Gesamthochschule Radiologisches Zentrum, Hufelandstraße 55, W-4300, Essen 1, Germany

    Eberhard Scherer

  2. Institut für Medizinische Strahlenphysik und Strahlenbiologie, Universitätsklinikum der Gesamthochschule, Hufelandstraße 55, W-4300, Essen 1, Germany

    Christian Streffer

  3. Department of Radiation Biology, The Medical College of St. Bartholomew’s Hospital, Charterhouse Square, London, EC1M 6BQ, UK

    Klaus-Rüdiger Trott

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© 1991 Springer-Verlag Berlin Heidelberg

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van der Kogel, A.J. (1991). The Nervous System: Radiobiology and Experimental Pathology. In: Scherer, E., Streffer, C., Trott, KR. (eds) Radiopathology of Organs and Tissues. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83416-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-83416-5_6

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