Abstract
The process by which eukaryotic cells control the expression of their genes constitutes one of the key unanswered questions in biology. While it is clear that post-tran-scriptional controls are involved in the fine tuning of gene expression it also seems clear that the primary level of control is exhibited at the transcriptional level. Considerable evidence accumulated over the past few years strongly suggests that the methylation of specific cytosine residues within and around genes may exert such transcriptional control (Razin and Riggs 1980).
This work was supported by grants GM25739 and T32-CA09320 from the National Institutes of Health
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© 1983 Springer-Verlag Berlin • Heidelberg
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Jones, P.A., Taylor, S.M., Wilson, V.L. (1983). Inhibition of DNA Methylation by 5-Azacytidine. In: Nass, G. (eds) Modified Nucleosides and Cancer. Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81947-6_15
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DOI: https://doi.org/10.1007/978-3-642-81947-6_15
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