Summary
Preferential swelling and vacuolation of dendrites were observed electron microscopically in different brain regions of rats treated with LiCl in a dose of 6–18 mmol/kg for 1–6 days. The most severe fine structural changes were revealed in the hippocampus. Low-dose (0.33 mmol/kg) lithium treatment lasting for a year did not cause any morphologically detectable alterations in the rat brain. In vitro studies showed a reduction of den-dro-axonal process network of neurons measured by morphometric means after lithium exposure. Using different cultures of neuronal and glial cell populations, higher lithium uptake was observed for neuron-enriched cultures.
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© 1981 Springer-Verlag Berlin, Heidelberg
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Janka, Z., Szentistvanyi, I., Juhasz, A., Kiraly, E., Parducz, A., Joo, F. (1981). Preferential Vulnerability of Dendrites to Lithium Ion in Rat Brain and in Nerve Cell Culture. In: Jellinger, K., Gullotta, F., Mossakowski, M. (eds) Experimental and Clinical Neuropathology. Acta Neuropathologica Supplementum, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81553-9_13
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DOI: https://doi.org/10.1007/978-3-642-81553-9_13
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