Summary
The therapeutic effects of 3% adenine arabinoside 5′-monophosphate (ara-AMP), 3% acyclovir (ACV) and 0.5% 5-iodo-2′-deoxyuridine (IDU) ointment on herpetic keratitis and their toxic effects on normal cornea in rabbits were compared. Ara-AMP showed the strongest antiviral activity, but it produced corneal erosion after 4 days application. Acyclovir showed an equal therapeutic effect to that of IDU and was found to be non-toxic. Acyclovir was, therefore, concluded to be the most effective for treatment of herpetic keratitis.
Zusammenfassung
Im Kaninchenmodell untersuchten wir vergleichend den therapeutischen und den toxischen Effekt von 3% Adeninarabinosid Monophosphat (Ara-AMP), 3% Acyclovir (ACV) und 0,5% IDU bei der Herpeskeratitis und bei Normalaugen. Ara-AMP erwies sich als stärkstes Virustatikum, führte aber nach 4tägiger lokaler Anwendung zu Hornhauterosionen. Acyclovir war annähernd so wirksam wie IDU, aber viel weniger toxisch als letzteres. Deshalb schließen wir, daß Acyclovir von den getesteten Virustatika das beste zur Therapie einer Herpeskeratitis ist.
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References
Elion GB, Furman PA, Fyfe JA, Miranda P de, Beauchamp L, Schaeffer HJ (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydro- xyethoxymethyl)guanine. Proc Natl Acad Sci USA 74: 5716–5720
Jones BR, Al-Hussaini MK (1963) Therapeutic considerations in ocular vaccinia. Trans Ophthalmol Soc UK 83: 613–631
Schaeffer HJ, Beauchamp L, Miranda P de, Elion GB, Bauer DJ, Collins P (1978) 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group. Nature 272: 583–585
Shiota H, Inoue S, Yamane S (1979) Efficacy of acycloguanosine against herpetic ulcers in rabbit cornea. Br J Ophthalmol 63: 425–428
Takashima R (1975) Corticosteroid effects on the corneal surface of rabbits studied by scanning electron microscopy. Jpn J Ophthalmol 19: 393–400
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© 1981 J.F. Bergmann Verlag, München
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Shiota, H., Ogawa, T., Yamane, S. (1981). Studies of Acyclovir and Ara-AMP Against Herpetic Keratitis in Rabbits. In: Sundmacher, R. (eds) Herpetische Augenerkrankungen. Internationales Symposion der Deutschen Ophthalmologischen Gesellschaft vom 12. bis 14. April 1980 in Freiburg. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-80499-1_50
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DOI: https://doi.org/10.1007/978-3-642-80499-1_50
Publisher Name: J.F. Bergmann-Verlag
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