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Gut Dysfunction in Trauma Patients

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Gut Dysfunction in Critical Illness

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 26))

Abstract

With the development of regionalized trauma care, patients who were previously found dead in the field are now surviving to be admitted to regional trauma centers [1]. Early in-hospital deaths occur as a result of severe brain injury and irreversible shock while the leading cause of late deaths is multiple organ failure (MOF). Early risk factors for MOF include high injury severity score (ISS), advanced age, blood transfusions, and persistent shock [2, 3]. While it is difficult to implicate gut dysfunction in early brain death, it has recently been emphasized to be important in the pathogenesis of irreversible hemorrhagic shock and MOF [4-14]. The principle mechanism by which gut dysfunction is presumed to mediate these adverse outcomes is bacterial translocation (BT). In this chapter, we would like to discuss three gut-related questions that specifically differentiate time after injury into resuscitation, the early systemic inflammatory response syndrome (SIRS) and late organ failure.

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Authors
  1. F. A. Moore
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  2. E. E. Moore
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Editors and Affiliations

  1. Department of Surgery, Pennsylvania University Hospital, 3400 Spruce Street, 19104, Philadelphia, PA, USA

    J. L. Rombeau

  2. Department of Intensive Care Critical Care Research Program, Kuopio University Hospital, FIN-70211, Kuopio, Finland

    J. Takala

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© 1996 Springer-Verlag Berlin Heidelberg

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Moore, F.A., Moore, E.E. (1996). Gut Dysfunction in Trauma Patients. In: Rombeau, J.L., Takala, J. (eds) Gut Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80224-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-80224-9_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80226-3

  • Online ISBN: 978-3-642-80224-9

  • eBook Packages: Springer Book Archive

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