Skip to main content

Extranodal Non-Hodgkin’s Lymphomas of the Oral Cavity

  • Chapter
Oral Pathology

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 90))

Abstract

Lymphomas are malignant neoplasms of component cells of lymphoid tissues. A broad division of the group into Hodgkin’s disease and non-Hodgkin’s lymphoma (NHL) is widely accepted. Hodgkin’s disease is primarily a nodal disease characterised by the presence of Reed-Sternberg cells and a lymphoid stroma composed of large numbers of non-neoplastic cells (Bonadonna et al. 1989). The condition rarely affects extranodal sites and will not be discussed here.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abemayor E, Canalis RF, Greenberg P, Wortham DG, Rowlands JP, Sun NCJ (1988) Plasma cell tumors of the head and neck. J Otolaryngol 17: 376–381

    PubMed  CAS  Google Scholar 

  • Alexanian R, Dimopoulos M (1994) The treatment of multiple myeloma. N Engl J Med 330: 484–489

    Article  PubMed  CAS  Google Scholar 

  • Anderrson M, Klein G, Ziegler J, Henle W (1976) Association of Epstein-Barr viral genomes with American Burkitt lymphoma. Nature 260: 357–359

    Article  Google Scholar 

  • Bateman AC, Wright DH (1993) Epitheliotropism in high-grade lymphomas of mucosa-associated lymphoid tissue. Histopathology 23: 409–415

    Article  PubMed  CAS  Google Scholar 

  • Batsakis JG (1983) Plasma cell tumours of the head and neck. Ann Otol Rhinol Laryngol 92: 311–313

    PubMed  CAS  Google Scholar 

  • Bonadonna G, Molinari R, Banfi A (1989) Hodgkin’s and non-Hodgkin’s lymphoma presenting in the head and neck. In: Suen Y, Myers EN (eds) Cancers of the head and neck, 2nd edn. Churchill Livingstone, New York, pp 877–896

    Google Scholar 

  • Bruce KW, Royer RQ (1953) Multiple myeloma occurring in the jaws: a study of seventeen cases. Oral Surg 6: 729–744

    Article  PubMed  CAS  Google Scholar 

  • Burke JS, Butler JJ (1992) Malignant lymphoma with a high content of epithelioid histiocytes ( Lennert’s lymphoma ). Am J Clin Pathol 16: 156–162

    Google Scholar 

  • Burkitt D (1958) A sarcoma involving the jaws in African children. Br J Surg 46: 218–233

    Article  PubMed  CAS  Google Scholar 

  • Burkitt D (1966) Malignant lymphoma of the jaws. J Dent Res 45: 554–559

    Article  Google Scholar 

  • Carbone A, Vaccher E, Barzan L, Gloghini A, Volpe R, de Re V et al (1995) Head and neck lymphomas associated with human immunodeficiency virus infection. Arch Otolaryngol Hend Neck Surg 121: 210–218

    Article  CAS  Google Scholar 

  • Chan JKC, Ng CS, Lau WH, Lo STH (1987) Most nasal/nasopharyngeal lymphomas are peripheral T-cell neoplasms. Am J Surg Pathol 50: 418–429

    Google Scholar 

  • Chan JKC, Banks PM, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B et al (1994) A proposal for classification of lymphoid neoplasms (by the International Lymphoma Study Group). Histopathology 25: 517–536

    Article  PubMed  CAS  Google Scholar 

  • Cobleigh MA, Kennedy JL (1986) Non-Hodgkin’s lymphomas of the upper aerodigestive tract and salivary glands. Otolaryngol Clin North Am 19: 685–710

    PubMed  CAS  Google Scholar 

  • Corwin J, Lindberg RD (1979) Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer 43: 1007–1013

    Article  PubMed  CAS  Google Scholar 

  • Diss TC, Wotherspoon AC, Speight PM, Pan L, Isaacson PG (1995) B-cell monoclonality, Epstein Barr virus and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. Am J Surg Pathol 19: 531–536

    Article  PubMed  CAS  Google Scholar 

  • Economopoulos T, Asprou N, Stathakis N, Fountzilas G, Pavlidis N, Papaspyrou S et al (1992) Primary extranodal non-Hodgkin’s lymphoma of the head and neck. Oncology 49: 484–488

    Article  PubMed  CAS  Google Scholar 

  • Fu YS, Perzin KH (1979) Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologic study. X. Malignant lymphomas. Cancer 43: 611–621

    Article  PubMed  CAS  Google Scholar 

  • Gleeson MJ, Bennet MH, Cawson RA (1986) Lymphomas of salivary glands. Cancer 58: 699–704

    Article  PubMed  CAS  Google Scholar 

  • Handlers JP, Howell RE, Abrams AM, Melrose RJ (1986) Extranodal oral lymphoma. 1. A morphologic and immunoperoxidase study of 34 cases. Oral Surg Oral Med Oral Pathol 61: 362–367

    Article  PubMed  CAS  Google Scholar 

  • Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML et al (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84: 1361–1392

    PubMed  CAS  Google Scholar 

  • Harrison DFN (1987) Midline lethal granuloma: fact or fiction. Laryngoscope 97: 1049–1053

    PubMed  CAS  Google Scholar 

  • Howell RE, Handlers JP, Abrams AM, Melrose RJ (1987) Extra-nodal oral lymphoma. II. Relationships between clinical features and the Lukes-Collins classification of 34 cases. Oral Surg Oral Med Oral Pathol 64: 597–602

    Article  PubMed  CAS  Google Scholar 

  • Hyjek E, Smith WJ, Isaacson PG (1988) Primary B-cell Lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol 19: 766–776

    Article  PubMed  CAS  Google Scholar 

  • Ioachim HL (1992) Lymphoma: an opportunistic neoplasia of AIDS. Leukemia 6: 305–335

    Google Scholar 

  • Irwin D, Kaplan L (1993) Clinical aspects of HIV-related lymphoma. Curr Opin Oncol 5: 852–860

    Article  PubMed  CAS  Google Scholar 

  • Isaacson PG (1990) Lymphomas of mucosa-associated lymphoid tissue (MALT). Histopathology 16: 617–619

    Article  PubMed  CAS  Google Scholar 

  • Isaacson PG (1992) Extranodal lymphomas: the MALT concept. Verh Dtsch Ges Pathol 76: 1423

    Google Scholar 

  • Isaacson PG (1993) Lymphomas of mucosa-associated lymphoid tissue (MALT-type lymphomas). Forum Trends Exp Clin Med 3: 234–245

    Google Scholar 

  • Isaacson PG, Norton AJ (1994) Extranodal lymphomas. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Isaacson PG, Wright DH (1983) Malignant lymphoma of mucosa-associated lymphoid tissues. A distinct type of B-cell lymphoma. Cancer 52: 1410–1416

    Google Scholar 

  • Isaacson PG, Wright DH (1984) Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 53: 2515–2524

    Article  PubMed  CAS  Google Scholar 

  • Isaacson PG, Wotherspoon AC, Diss T, Pan LX (1991) Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 15: 819–828

    Article  PubMed  CAS  Google Scholar 

  • Jordan RCK, Speight PM (1996) Sjögren’s syndrome: from histopathology to molecular pathology. Oral Surg Oral Med Oral Pathol 81: 308–320

    CAS  Google Scholar 

  • Jordan RCK, Diss TC, Lench NJ, Isaacson PG, Speight PM (1995) Immunoglobulin gene rearrangements in lymphoplasmacytic infiltrates of labial salivary glands in Sjögren’s syndrome. Oral Surg Oral Med Oral Pathol 79: 723–729

    CAS  Google Scholar 

  • Kassan SS, Thomas TL, Moutsopoulos HM, Hoover R, Kimberly RP, Budman DR et al (1978) Increased risk of lymphoma in sicca syndrome. Ann Intern Med 89: 888–892

    PubMed  CAS  Google Scholar 

  • Lennert K (1995) The proposal for a Revised European American Lymphoma classification–a new start of a transatlantic discussion. Histopathology 26: 481–483

    Article  PubMed  CAS  Google Scholar 

  • Lennert K, Feller AC (1990) Histopathology of non-Hodgkin’s lymphomas. Based on the updated Kiel classification, 2nd edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Lennert K, Mohri N, Stein H, Kaiserling E (1975) The histopathology of malignant lymphoma. Br J Haematol 31: 193–203

    Article  Google Scholar 

  • Levine AM (1992) Acquired immunodeficiency syndrome-related lymphoma. Blood 80: 8–20

    PubMed  CAS  Google Scholar 

  • Li G, Hansmann ML, Zwingers T, Lennert K (1990) Primary lymphomas of the lung: morphological, immunohistochemical and clinical features. Histopathology 16: 519–533

    Article  PubMed  CAS  Google Scholar 

  • Liepert DR, Kudryk WH, Jewell LD (1994) Nasal T-cell lymphoma: a case presentation. J Otolaryngol 23: 32–35

    PubMed  CAS  Google Scholar 

  • Lipford EH, Margolick JB, Longo DL, Fauci AS, Jaffe ES (1988) Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations. Blood 72: 1674–1681

    PubMed  Google Scholar 

  • Lukes RJ, Collins RD (1977) Lukes-Collins classification and its significance. Cancer Treat Rep 61: 971–979

    PubMed  CAS  Google Scholar 

  • Maxymiw WG, Patterson BJ, Wood RE, Meharchand JM, Munro AJ, Gorska-Flipot I (1992) B-cell lymphoma presenting as a midfacial necrotizing lesion. Oral Surg Oral Med Oral Pathol 74: 343–347

    Article  PubMed  CAS  Google Scholar 

  • McGurk M, Goepel JR, Hancock BW (1985) Extranodal lymphoma of the head and neck: a review of 49 consecutive cases. Clin Radiol 36: 455–458

    Article  PubMed  CAS  Google Scholar 

  • Meis JM, Butler JJ, Osbourne BM, Ordonez NG (1987) Solitary plasmacytomas of bone and extramedullary plasmacytomas. Cancer 59: 1475–1485

    Article  PubMed  CAS  Google Scholar 

  • Menarguez J, Mollejo M, Oliva H, Balla C, Forteza J, Martin C et al (1994) Waldeyer’s ring lymphomas. A clinicopathological study of 79 cases. Histopathology 24: 13–22

    Article  PubMed  CAS  Google Scholar 

  • Minerbrook M, Schulman P, Budman DR, Teichberg S, Vinciguerra V, Kardon N et al (1982) Burkitt’s leukemia: a re-evaluation. Cancer 49: 1444–1448

    Article  PubMed  CAS  Google Scholar 

  • Morton RP, Sillars HA, Benjamin CS (1992) Incidence of “unsuspected” extranodal head and neck lymphoma. Clin Otolaryngol 17: 373–375

    Article  PubMed  CAS  Google Scholar 

  • Ngan B, Warnke RA, Wilson M, Tagaki K, Cleary ML, Dorfman RF (1991) Monocytoid B-cell lymphoma: a study of 36 cases. Hum Pathol 22: 409–421

    Article  PubMed  CAS  Google Scholar 

  • Nizze H, Cogliatti SB, von Schilling C, Feller AC, Lennert K (1991) Monocytoid B-cell lymphoma: morphological variants and relationship to low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue. Histopathology 18: 403–414

    Article  PubMed  CAS  Google Scholar 

  • Ortiz-Hidalgo C, Wright DH (1992) The morphological spectrum of monocytoid B-cell lymphoma and its relationship to lymphomas of mucosa-associated lymphoid tissue. Histopathology 21: 555–561

    Article  PubMed  CAS  Google Scholar 

  • Pals ST, Horst E, Scheper RJ, Meijer CLMJ (1989) Mechanisms of human lymphocyte migration and their role in the pathogenesis of disease. Immunol Rev 108: 111–133

    Article  PubMed  CAS  Google Scholar 

  • Parveen T, Navarro-Roman L, Medeiros LJ, Raffeld M, Jaffe ES (1993) Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue arising in the kidney. Arch Pathol Lab Med 117: 780–783

    PubMed  CAS  Google Scholar 

  • Patton LL, McMillan CW, Webster WP (1990) American Burkitt’s lymphoma: a 10 year review and case study. Oral Surg Oral Med Oral Pathol 69: 307–316

    Article  PubMed  CAS  Google Scholar 

  • Paulsen J, Lennert K (1994) Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type in Waldeyer’s ring. Histopathology 24: 1–11

    Article  PubMed  CAS  Google Scholar 

  • Pelicci PG, Knowles DM, Magrath I, Dalla-Favera R (1986) Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci USA 83: 2984–2988

    Article  PubMed  CAS  Google Scholar 

  • Ramsay AD, Rooney N (1993) Lymphomas of the head and neck. 1. Nasofacial T-cell lymphoma. Oral Oncol Eur J Cancer [B] 29B: 99–102

    Google Scholar 

  • Ramsay AD, Michaels L, Isaacson PG (1988) Lethal midline granuloma - a T-cell lymphoma? J Pathol 154: 56

    Google Scholar 

  • Ratech H, Burke JS, Blayney DW, Sheibani K, Rappaport H (1989) A clinicopathologic study of malignant lymphomas of the nose, paranasal sinuses, and hard palate, including cases of lethal midline granuloma. Cancer 64: 2525–2531

    Article  PubMed  CAS  Google Scholar 

  • Regezi JA, Zarbo RJ, Stewart JCB (1991) Extranodal oral lymphomas: histologic subtypes and immunophenotypes (in routinely processed tissue). Oral Surg Oral Med Oral Pathol 72: 702–708

    Article  PubMed  CAS  Google Scholar 

  • Reinish EI, Raviv M, Srolovitz H, Gornitsky M (1994) Tongue, primary amyloidosis, and multiple myeloma. Oral Surg Oral Med Oral Pathol 77: 121–125

    Article  PubMed  CAS  Google Scholar 

  • Robbins KT, Fuller LM, Vlasak M, Osborne B, Jing BS, Velasquez WS et al (1985) Primary lymphomas of the nasal cavity and paranasal sinuses. Cancer 56: 814–819

    Article  PubMed  CAS  Google Scholar 

  • Rooney N, Ramsay AD (1994) Lymphomas of the head and neck. 2. The B-cell lymphomas. Oral Oncol Eur J Cancer 30B: 155–159

    Article  CAS  Google Scholar 

  • Rosenberg SA (1994) Classification of lymphoid neoplasms. Blood 5: 1359–1360

    Google Scholar 

  • Rosenberg SA, Berard CW, Brown BWJ, Burke J, Dorfman RF, Glatstein E et al (1982) National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas. Cancer 49: 2112–2135

    Article  Google Scholar 

  • Salhany KE, Pietra GG (1993) Extranodal lymphoid disorders. Am J Clin Pathol 99: 472–485

    PubMed  CAS  Google Scholar 

  • Schmid U, Helbron D, Lennert K (1982) Development of malignant lymphomas in myoepithelial sialadenitis ( Sjögren’s syndrome ). Virchows Arch [A] Pathol Anat Histopathol 395: 11–43

    Article  CAS  Google Scholar 

  • Serraino D, Salamina G, Franceschi S, La Vecchia C, Brunet JB, Ancelle-Park R (1992) The epidemiology of AIDS-associated non-Hodgkin’s lymphoma in the World Health Organization European region. Br J Cancet 66: 912–916

    Article  CAS  Google Scholar 

  • Shaefer BC, Woisetchlaeger M, Strominger JL, Speck SH (1991) Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from promoters used in latently infected lymphocytes. Proc Natl Acad Sci USA 88: 6550–6554

    Article  Google Scholar 

  • Silverman S, Migliorati CA, Lazada-Nur F, Greenspan D, Conant MA (1986) Oral findings in people with or at high risk for AIDS: a study of 375 homosexual males. JADA 112: 187–192

    PubMed  Google Scholar 

  • Stansfeld AG, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O et al (1988) Updated Kiel classification for lymphomas. Lancet 1: 292–293

    Article  PubMed  CAS  Google Scholar 

  • Stein H (1995) Critique of the critique. Ann Oncol 6: 109–111

    PubMed  CAS  Google Scholar 

  • Stewart JP (1933) Progressive lethal granulomatous ulceration of the nose. J Laryngol Otol 48: 657–701

    Article  Google Scholar 

  • Takagi N, Nakamura S, Yamamoto K, Kunishima K, Takagi I, Suyama M et al (1992) Malignant lymphoma of mucosa-associated lymphoid tissue arising in the thymus of a patient with Sjogren’s syndrome. A morphologic, phenotypic, and genotypic study. Cancer 69: 1347–1355

    Article  PubMed  CAS  Google Scholar 

  • Thompson SH, Altini M (1989) Gigantiform cementoma of the jaws. Head Neck 11: 538–544

    Article  PubMed  CAS  Google Scholar 

  • Wax MK, Yun KJ, Omar RA (1993) Extramedullary plasmacytomas of the head and neck. Otolaryngol. Head Neck Surg 109: 877–885

    PubMed  CAS  Google Scholar 

  • Wiltshaw E (1976) The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine 55: 217–238

    Article  PubMed  CAS  Google Scholar 

  • Wotherspoon AC, Pan LX, Diss TC, Isaacson PG (1990) A genotypic study of low grade B-cell lymphomas, including lymphomas of mucosa-associated lymphoid tissue ( MALT ). J Pathol 162: 135–140

    Article  PubMed  CAS  Google Scholar 

  • Wotherspoon AC, Diss TC, Pan LX, Schmid C, Kerr-Muir MG, Hardman Lea S et al (1993) Primary low-grade B-cell lymphoma of conjunctiva: a mucosa-associated lymphoid tissue type lymphoma. Histopathology 23: 417–424

    Article  PubMed  CAS  Google Scholar 

  • Wright DH (1994) Lymphomas of Waldeyer’s ring. Histopathology 24: 97–99

    Article  PubMed  CAS  Google Scholar 

  • Ziegler JL (1981) Burkitt’s lymphoma. N Engl J Med 305: 735–745

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Jordan, R.C.K., Speight, P.M. (1996). Extranodal Non-Hodgkin’s Lymphomas of the Oral Cavity. In: Seifert, G. (eds) Oral Pathology. Current Topics in Pathology, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80169-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80169-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80171-6

  • Online ISBN: 978-3-642-80169-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics