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Transposition of Phage Mu DNA

  • Chapter
Transposable Elements

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 204))

Abstract

The temperate bacteriophage Mu has been an extremely useful model system for studies on the mechanistic aspects of DNA transposition. Mu was the first element for which a soluble in vitro transposition system was established (Mizuuchi 1983). Furthermore, some of the features of the Mu system, such as the polarity of strand transfer and the chemical steps of the reaction, appear to be conserved in a wide variety of elements from bacterial transposons through mammalian viruses. The purpose of this review is to summarize the biochemical details of Mu DNA transposition which have been gleaned over recent years. Due to space limitations, an exhaustive review of the literature cannot be performed here and the reader is also referred to several other recent reviews (Pato 1989; Mizuuchi 1992a, b; Haniford and Chaconas 1992).

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Authors and Affiliations

  1. Department of Biochemistry, University of Western Ontario, N6A 5C1, London, Ontario, Canada

    B. D. Lavoie & G. Chaconas

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  1. B. D. Lavoie
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  2. G. Chaconas
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Editors and Affiliations

  1. Max-Planck-Institut für Züchtungsforschung, Carl-von-Linné-Weg 10, D-50829, Köln, Germany

    Heinz Saedler

  2. Lehrstuhl und Institut für Genetik, Technische Universität München, Lichtenbergstraße 4, D-85747, Garching, Germany

    Alfons Gierl

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© 1996 Springer-Verlag Berlin Heidelberg

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Lavoie, B.D., Chaconas, G. (1996). Transposition of Phage Mu DNA. In: Saedler, H., Gierl, A. (eds) Transposable Elements. Current Topics in Microbiology and Immunology, vol 204. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79795-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-79795-8_4

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