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The Structure of the HMG Box and Its Interaction with DNA

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Nucleic Acids and Molecular Biology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 9))

Abstract

A number of eukaryotic DNA binding domains are now known which recognise DNA by insertion of an α-helix (pre-existing or induced), into the major groove of the DNA, e.g. the homeobox, zinc finger and bZIP/bHLH motifs. The HMG box differs from these domains in three important respects: (1) the principle contacts are to the minor groove, (2) a considerable bend is introduced into the DNA on binding and (3) there is wide variation in the DNA sequence specificity between members of the HMG box family. From this it is clear that new principles will be revealed by understanding the nature of the interaction between the HMG box and DNA. However, the structure of an HMG box bound to DNA is not presently available.

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Authors and Affiliations

  1. Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK

    C. M. Read, P. D. Cary & C. Crane-Robinson

  2. Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK

    P. C. Driscoll

  3. Department of Biochemistry, University of Dundee, Dundee, DD1 4HN, UK

    M. O. M. Carrillo & D. G. Norman

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  1. C. M. Read
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  2. P. D. Cary
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  3. C. Crane-Robinson
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  4. P. C. Driscoll
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  5. M. O. M. Carrillo
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  6. D. G. Norman
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Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, Dundee, DD1 4HN, UK

    David M. J. Lilley

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© 1995 Springer-Verlag Berlin Heidelberg

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Read, C.M., Cary, P.D., Crane-Robinson, C., Driscoll, P.C., Carrillo, M.O.M., Norman, D.G. (1995). The Structure of the HMG Box and Its Interaction with DNA. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79488-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-79488-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79490-2

  • Online ISBN: 978-3-642-79488-9

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