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Interactions between the in vitro metabolism of xenobiotics and fatty acids

The case of ibuprofen and other chiral profens

  • Conference paper
Toxicology in Transition

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 17))

Abstract

Xenobiotic carboxylic acids can act as substrates for the pathways of fatty acid biotransformation. Thus, they can form abnormal fatty acids by addition of 2-carbon units, or be conjugated with cholesterol, bile acids, carnitine and other amino acids. Finally, xenobiotic carboxylic acids can substitute endogeneous fatty acids in glycerolipid synthesis producing hybrid triacylglycerols and phospholipids (Caldwell, 1985; Caldwell and Marsh, 1983; Huston, 1982). In order to enter the routes of lipid biochemistry, xenobiotic acids like natural fatty acids must be activated by coenzyme A. The acyl-CoA thioesters thus formed are pivotal in the metabolism of xenobiotic acids (Fig. 1).

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Authors and Affiliations

  1. Ecole de Pharmacie, Université de Lausanne, BEP, CH-1015, Lausanne, Suisse

    J. M. Mayer, B. Testa, M. Roy-de Vos, C. Audergon & J. C. Etter

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  1. J. M. Mayer
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  2. B. Testa
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  3. M. Roy-de Vos
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  4. C. Audergon
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  5. J. C. Etter
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Editors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystr. 67, D-44139, Dortmund, Germany

    Gisela H. Degen

  2. Interkantonale Kontrollstelle für Heilmittel, Erlachstr. 8, CH-3000, Bern 9, Switzerland

    Jürg P. Seiler

  3. Ciba-Geigy Ltd., K-136.3.23, CH-4002, Basel, Switzerland

    Philip Bentley

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© 1995 Springer-Verlag Berlin Heidelberg

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Mayer, J.M., Testa, B., Vos, M.Rd., Audergon, C., Etter, J.C. (1995). Interactions between the in vitro metabolism of xenobiotics and fatty acids. In: Degen, G.H., Seiler, J.P., Bentley, P. (eds) Toxicology in Transition. Archives of Toxicology, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79451-3_43

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  • DOI: https://doi.org/10.1007/978-3-642-79451-3_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79453-7

  • Online ISBN: 978-3-642-79451-3

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